hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05574
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LNPK | Endoplasmic reticulum junction formation protein lunapark (ER junction formation factor lunapark) | UniProt NCBI |
| SEC61A1 | Protein transport protein Sec61 subunit alpha isoform 1 (Sec61 alpha-1) | UniProt NCBI |
| TM9SF2 | Transmembrane 9 superfamily member 2 (p76) | UniProt NCBI |
| ATP1A3 | Sodium/potassium-transporting ATPase subunit alpha-3 (Na(+)/K(+) ATPase alpha-3 subunit) (EC 7.2.2.13) (Na(+)/K(+) ATPase alpha(III) subunit) (Sodium pump subunit alpha-3) | UniProt NCBI |
| ATP1B3 | Sodium/potassium-transporting ATPase subunit beta-3 (Sodium/potassium-dependent ATPase subunit beta-3) (ATPB-3) (CD antigen CD298) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04964 | 0.00081380532431 | 0.4 | ATP1A3 ATP1B3 | Proximal tubule bicarbonate reclamation |
| KEGG:04960 | 0.00198873883948 | 0.4 | ATP1A3 ATP1B3 | Aldosterone-regulated sodium reabsorption |
| KEGG:04973 | 0.00333191455164 | 0.4 | ATP1A3 ATP1B3 | Carbohydrate digestion and absorption |
| KEGG:04978 | 0.00441762805526 | 0.4 | ATP1A3 ATP1B3 | Mineral absorption |
| KEGG:04961 | 0.00522578105965 | 0.4 | ATP1A3 ATP1B3 | Endocrine and other factor-regulated calcium reabsorption |
| KEGG:04976 | 0.00656425237639 | 0.4 | ATP1A3 ATP1B3 | Bile secretion |
| KEGG:04971 | 0.00779513141567 | 0.4 | ATP1A3 ATP1B3 | Gastric acid secretion |
| KEGG:04918 | 0.00969431019543 | 0.4 | ATP1A3 ATP1B3 | Thyroid hormone synthesis |
| KEGG:04911 | 0.0108715181024 | 0.4 | ATP1A3 ATP1B3 | Insulin secretion |
| KEGG:04970 | 0.0114851584748 | 0.4 | ATP1A3 ATP1B3 | Salivary secretion |
| KEGG:04974 | 0.0117982317972 | 0.4 | ATP1A3 ATP1B3 | Protein digestion and absorption |
| KEGG:04260 | 0.0121154716042 | 0.4 | ATP1A3 ATP1B3 | Cardiac muscle contraction |
| REAC:R-HSA-5578775 | 0.0132857243802 | 0.4 | ATP1A3 ATP1B3 | Ion homeostasis |
| KEGG:04972 | 0.0137641082753 | 0.4 | ATP1A3 ATP1B3 | Pancreatic secretion |
| REAC:R-HSA-936837 | 0.0145030354259 | 0.4 | ATP1A3 ATP1B3 | Ion transport by P-type ATPases |
| KEGG:04925 | 0.0162467151192 | 0.4 | ATP1A3 ATP1B3 | Aldosterone synthesis and secretion |
| KEGG:04919 | 0.0267668372004 | 0.4 | ATP1A3 ATP1B3 | Thyroid hormone signaling pathway |
| KEGG:04261 | 0.0348468299156 | 0.4 | ATP1A3 ATP1B3 | Adrenergic signaling in cardiomyocytes |
| KEGG:04022 | 0.0415917953149 | 0.4 | ATP1A3 ATP1B3 | cGMP-PKG signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ATP1A3 | ATP1B3 | 0.228 | 0.468 | bioplex (ATP1B3) bioplex_WMM Guru boldt fraction boldt_WMM |
| LNPK | ATP1B3 | 0.205 | 0.454 | bioplex (ATP1B3) bioplex_WMM boldt gupta_WMM boldt_WMM |
| TM9SF2 | ATP1B3 | 0.072 | 0.354 | bioplex (ATP1B3) bioplex_WMM boldt gupta_WMM boldt_WMM |
| SEC61A1 | ATP1B3 | 0.054 | 0.304 | bioplex (ATP1B3,SEC61A1) bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| LNPK | TM9SF2 | 0.007 | 0.002 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| SEC61A1 | LNPK | 0.007 | 0.004 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SEC61A1 | TM9SF2 | 0.005 | 0.01 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| ATP1A3 | LNPK | 0.004 | 0.008 | bioplex_WMM WMM_only |
| SEC61A1 | ATP1A3 | 0.003 | 0.014 | bioplex_WMM boldt boldt_WMM |
| ATP1A3 | TM9SF2 | 0.0 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05574 has an average edge precision of 0.163 which is ranked 6600 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| LNPK | HuMAP2_02369 HuMAP2_04397 HuMAP2_05574 |
| SEC61A1 | HuMAP2_00906 HuMAP2_01092 HuMAP2_01521 HuMAP2_03276 HuMAP2_05574 HuMAP2_06982 |
| TM9SF2 | HuMAP2_04397 HuMAP2_05574 |
| ATP1A3 | HuMAP2_04397 HuMAP2_04475 HuMAP2_05574 |
| ATP1B3 | HuMAP2_04397 HuMAP2_05574 HuMAP2_05916 |