hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05575
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IFIT5 | Interferon-induced protein with tetratricopeptide repeats 5 (IFIT-5) (Interferon-induced 58 kDa protein) (Retinoic acid- and interferon-inducible 58 kDa protein) (P58) | UniProt NCBI |
| RAPGEF1 | Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G) | UniProt NCBI |
| PEAK1 | Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269) | UniProt NCBI |
| PRAG1 | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | UniProt NCBI |
| DOCK1 | Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180) | UniProt NCBI |
| CRKL | Crk-like protein | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP313 | 8.94077488385e-06 | 0.5 | DOCK1 RAPGEF1 CRKL | Signaling of Hepatocyte Growth Factor Receptor |
| CORUM:2476 | 5.0322056017e-05 | 0.333333333333 | CRKL RAPGEF1 | CRKL-PDGFRA-CRK-RAPGEF1 complex |
| REAC:R-HSA-170968 | 0.000620139265586 | 0.333333333333 | CRKL RAPGEF1 | Frs2-mediated activation |
| REAC:R-HSA-8875555 | 0.000996295422965 | 0.333333333333 | CRKL RAPGEF1 | MET activates RAP1 and RAC1 |
| REAC:R-HSA-169893 | 0.0012174763081 | 0.333333333333 | CRKL RAPGEF1 | Prolonged ERK activation events |
| WP:WP306 | 0.00159070884596 | 0.5 | DOCK1 RAPGEF1 CRKL | Focal Adhesion |
| REAC:R-HSA-9027284 | 0.00172598429993 | 0.333333333333 | CRKL RAPGEF1 | Erythropoietin activates RAS |
| KEGG:04510 | 0.00181065209593 | 0.5 | DOCK1 RAPGEF1 CRKL | Focal adhesion |
| REAC:R-HSA-912631 | 0.00419905151199 | 0.333333333333 | CRKL RAPGEF1 | Regulation of signaling by CBL |
| WP:WP286 | 0.00477752328717 | 0.333333333333 | CRKL RAPGEF1 | IL-3 Signaling Pathway |
| REAC:R-HSA-9006335 | 0.0055883638448 | 0.333333333333 | CRKL RAPGEF1 | Signaling by Erythropoietin |
| REAC:R-HSA-186763 | 0.00774747127227 | 0.333333333333 | CRKL RAPGEF1 | Downstream signal transduction |
| WP:WP585 | 0.00792327646772 | 0.333333333333 | CRKL RAPGEF1 | Interferon type I signaling pathways |
| WP:WP4205 | 0.00883210845165 | 0.333333333333 | CRKL RAPGEF1 | MET in type 1 papillary renal cell carcinoma |
| REAC:R-HSA-187687 | 0.00895825109095 | 0.333333333333 | CRKL RAPGEF1 | Signalling to ERKs |
| KEGG:05211 | 0.0120956152943 | 0.333333333333 | CRKL RAPGEF1 | Renal cell carcinoma |
| KEGG:05131 | 0.0124835568261 | 0.333333333333 | DOCK1 CRKL | Shigellosis |
| REAC:R-HSA-8875878 | 0.0146740061797 | 0.333333333333 | CRKL RAPGEF1 | MET promotes cell motility |
| REAC:R-HSA-512988 | 0.0146740061797 | 0.333333333333 | CRKL RAPGEF1 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| KEGG:05100 | 0.0162469525174 | 0.333333333333 | DOCK1 CRKL | Bacterial invasion of epithelial cells |
| WP:WP23 | 0.021066272601 | 0.333333333333 | CRKL RAPGEF1 | B Cell Receptor Signaling Pathway |
| WP:WP185 | 0.0235215924424 | 0.333333333333 | DOCK1 RAPGEF1 | Integrin-mediated Cell Adhesion |
| MIRNA:hsa-miR-3202 | 0.0236038745097 | 0.5 | PRAG1 RAPGEF1 PEAK1 | hsa-miR-3202 |
| GO:0046579 | 0.0256111051648 | 0.5 | CRKL RAPGEF1 PRAG1 | positive regulation of Ras protein signal transduction |
| GO:0051057 | 0.0273937790841 | 0.5 | CRKL RAPGEF1 PRAG1 | positive regulation of small GTPase mediated signal transduction |
| REAC:R-HSA-186797 | 0.0314333263146 | 0.333333333333 | CRKL RAPGEF1 | Signaling by PDGF |
| KEGG:04722 | 0.0348461971614 | 0.333333333333 | CRKL RAPGEF1 | Neurotrophin signaling pathway |
| KEGG:05135 | 0.0381607333212 | 0.333333333333 | DOCK1 CRKL | Yersinia infection |
| KEGG:04910 | 0.0474671394747 | 0.333333333333 | CRKL RAPGEF1 | Insulin signaling pathway |
| CORUM:5444 | 0.0499726005494 | 0.166666666667 | RAPGEF1 | CRKII-C3G complex |
| CORUM:5337 | 0.0499726005494 | 0.166666666667 | DOCK1 | ELMO1-DOCK1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CRKL | PRAG1 | 0.073 | 0.355 | hein_WMM hein (CRKL) |
| RAPGEF1 | CRKL | 0.051 | 0.298 | hein_WMM hein (CRKL) gupta_WMM |
| DOCK1 | CRKL | 0.048 | 0.295 | hein_WMM hein (CRKL) |
| CRKL | PEAK1 | 0.029 | 0.231 | hein_WMM hein (CRKL) gupta_WMM |
| CRKL | IFIT5 | 0.021 | 0.188 | bioplex (IFIT5) bioplex_WMM gupta_WMM |
| DOCK1 | PEAK1 | 0.008 | 0.083 | hein_WMM bioplex_WMM WMM_only |
| RAPGEF1 | PRAG1 | 0.008 | 0.062 | hein_WMM WMM_only |
| DOCK1 | PRAG1 | 0.008 | 0.062 | hein_WMM WMM_only |
| DOCK1 | RAPGEF1 | 0.008 | 0.023 | hein_WMM WMM_only |
| PRAG1 | PEAK1 | 0.008 | 0.023 | hein_WMM WMM_only |
| RAPGEF1 | PEAK1 | 0.007 | 0.002 | hein_WMM WMM_only |
| PEAK1 | IFIT5 | 0.007 | 0.008 | youn_WMM gupta_WMM WMM_only |
| RAPGEF1 | IFIT5 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only |
| DOCK1 | IFIT5 | 0.007 | 0.001 | youn_WMM WMM_only |
Images
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Complex HuMAP2_05575 has an average edge precision of 0.117 which is ranked 6886 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IFIT5 | HuMAP2_05575 |
| RAPGEF1 | HuMAP2_02955 HuMAP2_05575 |
| PEAK1 | HuMAP2_05575 HuMAP2_06738 |
| PRAG1 | HuMAP2_02955 HuMAP2_05575 |
| DOCK1 | HuMAP2_01146 HuMAP2_03199 HuMAP2_03437 HuMAP2_03968 HuMAP2_04378 HuMAP2_04556 HuMAP2_05175 HuMAP2_05349 HuMAP2_05575 |
| CRKL | HuMAP2_02955 HuMAP2_05575 |