hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05582
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NFE2L1 | Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)] | UniProt NCBI |
| NFE2L3 | Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3) | UniProt NCBI |
| NFE2L2 | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2) | UniProt NCBI |
| MAFF | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | UniProt NCBI |
| BACH2 | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4269 | 0.00015011307213 | 0.4 | MAFF NFE2L2 | Ethanol metabolism resulting in production of ROS by CYP2E1 |
| GO:0000976 | 0.00331253751857 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | transcription regulatory region sequence-specific DNA binding |
| GO:1990837 | 0.00488043683738 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | sequence-specific double-stranded DNA binding |
| GO:0001067 | 0.00773964591478 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | regulatory region nucleic acid binding |
| GO:0044212 | 0.00773964591478 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | transcription regulatory region DNA binding |
| GO:0003690 | 0.00901216563471 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | double-stranded DNA binding |
| GO:0000790 | 0.0171953090779 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | nuclear chromatin |
| GO:0043565 | 0.0182392633913 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | sequence-specific DNA binding |
| GO:0000981 | 0.0187192194024 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| WP:WP2884 | 0.0200904134765 | 0.4 | MAFF NFE2L2 | NRF2 pathway |
| GO:0000785 | 0.0394223237212 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | chromatin |
| GO:0003700 | 0.0459792824187 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | DNA-binding transcription factor activity |
| GO:0044454 | 0.046479053704 | 1.0 | NFE2L2 MAFF NFE2L1 NFE2L3 BACH2 | nuclear chromosome part |
| CORUM:7489 | 0.0499494897235 | 0.2 | NFE2L1 | EglN2-NRF1-PGC1alpha complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAFF | BACH2 | 0.998 | 0.939 | bioplex (MAFF) bioplex_WMM |
| MAFF | NFE2L1 | 0.974 | 0.886 | bioplex (MAFF) bioplex_WMM |
| MAFF | NFE2L2 | 0.169 | 0.426 | bioplex (MAFF) bioplex_WMM |
| MAFF | NFE2L3 | 0.108 | 0.373 | bioplex (MAFF) bioplex_WMM |
| NFE2L1 | NFE2L2 | 0.01 | 0.105 | bioplex_WMM WMM_only |
| NFE2L1 | NFE2L3 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| NFE2L2 | NFE2L3 | 0.009 | 0.104 | bioplex_WMM WMM_only |
| BACH2 | NFE2L1 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| BACH2 | NFE2L2 | 0.009 | 0.107 | bioplex_WMM WMM_only |
| BACH2 | NFE2L3 | 0.009 | 0.094 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05582 has an average edge precision of 0.325 which is ranked 4282 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NFE2L1 | HuMAP2_01275 HuMAP2_02263 HuMAP2_02456 HuMAP2_05582 |
| NFE2L3 | HuMAP2_03692 HuMAP2_04720 HuMAP2_05582 HuMAP2_06288 HuMAP2_06622 |
| NFE2L2 | HuMAP2_02263 HuMAP2_05582 |
| MAFF | HuMAP2_01275 HuMAP2_01303 HuMAP2_02263 HuMAP2_02456 HuMAP2_05582 |
| BACH2 | HuMAP2_01275 HuMAP2_01303 HuMAP2_02263 HuMAP2_02456 HuMAP2_04193 HuMAP2_05582 HuMAP2_05753 |