hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05584
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRDX1 | Peroxiredoxin-1 (EC 1.11.1.15) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) | UniProt NCBI |
| PRDX2 | Peroxiredoxin-2 (EC 1.11.1.15) (Natural killer cell-enhancing factor B) (NKEF-B) (PRP) (Thiol-specific antioxidant protein) (TSA) (Thioredoxin peroxidase 1) (Thioredoxin-dependent peroxide reductase 1) | UniProt NCBI |
| PRDX3 | Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.15) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) | UniProt NCBI |
| RNMT | mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (RG7MT1) (mRNA (guanine-N(7)-)-methyltransferase) (mRNA cap methyltransferase) (hCMT1) (hMet) (hcm1p) | UniProt NCBI |
| GCK | Glucokinase (EC 2.7.1.2) (Hexokinase type IV) (HK IV) (Hexokinase-4) (HK4) (Hexokinase-D) | UniProt NCBI |
| MTRR | Methionine synthase reductase (MSR) (EC 1.16.1.8) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0008379 | 1.81582264982e-05 | 0.5 | PRDX2 PRDX3 PRDX1 | thioredoxin peroxidase activity |
| GO:0051920 | 1.81582264982e-05 | 0.5 | PRDX2 PRDX3 PRDX1 | peroxiredoxin activity |
| REAC:R-HSA-3299685 | 2.16753530756e-05 | 0.5 | PRDX2 PRDX3 PRDX1 | Detoxification of Reactive Oxygen Species |
| WP:WP15 | 7.44944740613e-05 | 0.5 | PRDX2 PRDX3 PRDX1 | Selenium Micronutrient Network |
| HP:0003658 | 0.000750968775169 | 0.333333333333 | PRDX1 MTRR | Hypomethioninemia |
| REAC:R-HSA-1643685 | 0.000968789017735 | 0.833333333333 | PRDX1 GCK RNMT MTRR PRDX2 | Disease |
| HP:0003524 | 0.0015764696333 | 0.333333333333 | PRDX1 MTRR | Decreased methionine synthase activity |
| HP:0003223 | 0.00210158306671 | 0.333333333333 | PRDX1 MTRR | Decreased methylcobalamin |
| HP:0002160 | 0.00270155144475 | 0.333333333333 | PRDX1 MTRR | Hyperhomocystinemia |
| HP:0002156 | 0.00270155144475 | 0.333333333333 | PRDX1 MTRR | Homocystinuria |
| HP:0010919 | 0.00270155144475 | 0.333333333333 | PRDX1 MTRR | Abnormal circulating homocysteine concentration |
| GO:0042744 | 0.0032070828615 | 0.5 | PRDX2 PRDX3 PRDX1 | hydrogen peroxide catabolic process |
| REAC:R-HSA-8863678 | 0.00464022545552 | 0.333333333333 | PRDX2 PRDX1 | Neurodegenerative Diseases |
| REAC:R-HSA-8862803 | 0.00464022545552 | 0.333333333333 | PRDX2 PRDX1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| HP:0010901 | 0.00495018352279 | 0.333333333333 | PRDX1 MTRR | Abnormal circulating methionine concentration |
| GO:0045454 | 0.00661098268806 | 0.5 | PRDX2 PRDX3 PRDX1 | cell redox homeostasis |
| HP:0004339 | 0.00899388668352 | 0.333333333333 | PRDX1 MTRR | Abnormal circulating sulfur amino acid concentration |
| HP:0001889 | 0.00899388668352 | 0.333333333333 | PRDX1 MTRR | Megaloblastic anemia |
| HP:0010899 | 0.0101912456166 | 0.333333333333 | PRDX1 MTRR | Abnormal circulating aspartate family amino acid concentration |
| HP:0040126 | 0.0114630974264 | 0.333333333333 | PRDX1 MTRR | Abnormal vitamin B12 level |
| GO:0042743 | 0.0140408309691 | 0.5 | PRDX2 PRDX3 PRDX1 | hydrogen peroxide metabolic process |
| GO:0017001 | 0.0192515670318 | 0.5 | PRDX2 PRDX3 PRDX1 | antibiotic catabolic process |
| GO:0004601 | 0.0222806450818 | 0.5 | PRDX2 PRDX3 PRDX1 | peroxidase activity |
| HP:0004341 | 0.0224484879882 | 0.333333333333 | PRDX1 MTRR | Abnormality of vitamin B12 metabolism |
| GO:0051187 | 0.0239073169747 | 0.5 | PRDX2 PRDX3 PRDX1 | cofactor catabolic process |
| CORUM:3151 | 0.0249904952816 | 0.166666666667 | PRDX1 | Sulphiredoxin-peroxiredoxin complex |
| GO:0016684 | 0.0292571070793 | 0.5 | PRDX2 PRDX3 PRDX1 | oxidoreductase activity, acting on peroxide as acceptor |
| HP:0004340 | 0.034757762481 | 0.333333333333 | PRDX1 MTRR | Abnormality of vitamin B metabolism |
| MIRNA:hsa-miR-23b-3p | 0.0404895558515 | 0.5 | PRDX1 PRDX3 RNMT | hsa-miR-23b-3p |
| CORUM:6675 | 0.0499726005494 | 0.166666666667 | PRDX1 | PI4K2A-PRDX1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRDX2 | PRDX3 | 0.998 | 0.945 | hein_WMM bioplex (PRDX3) bioplex_WMM boldt (PRDX2) youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PRDX2 | PRDX1 | 0.993 | 0.918 | hein_WMM bioplex_WMM boldt (PRDX2) hein (PRDX1) Malo fraction boldt_WMM treiber_WMM |
| PRDX3 | PRDX1 | 0.917 | 0.84 | hein_WMM bioplex (PRDX3) bioplex_WMM boldt Malo fraction boldt_WMM treiber_WMM |
| PRDX3 | RNMT | 0.324 | 0.512 | bioplex (RNMT) bioplex_WMM fraction |
| PRDX3 | MTRR | 0.109 | 0.375 | fraction |
| PRDX2 | RNMT | 0.068 | 0.347 | bioplex (RNMT) bioplex_WMM youn_WMM fraction |
| GCK | PRDX3 | 0.051 | 0.294 | fraction |
| PRDX1 | RNMT | 0.029 | 0.231 | bioplex (RNMT) bioplex_WMM fraction |
| PRDX1 | MTRR | 0.007 | 0.006 | hein_WMM WMM_only |
Images
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Complex HuMAP2_05584 has an average edge precision of 0.496 which is ranked 2519 out of all 6965 complexes.
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