hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05586
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SPAST | Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein) | UniProt NCBI |
| CMTR1 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O-ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain-containing protein 2) (Interferon-stimulated gene 95 kDa protein) (ISG95) | UniProt NCBI |
| CHID1 | Chitinase domain-containing protein 1 (Stabilin-1-interacting chitinase-like protein) (SI-CLP) | UniProt NCBI |
| RNASEH2A | Ribonuclease H2 subunit A (RNase H2 subunit A) (EC 3.1.26.4) (Aicardi-Goutieres syndrome 4 protein) (AGS4) (RNase H(35)) (Ribonuclease HI large subunit) (RNase HI large subunit) (Ribonuclease HI subunit A) | UniProt NCBI |
| RNASEH2B | Ribonuclease H2 subunit B (RNase H2 subunit B) (Aicardi-Goutieres syndrome 2 protein) (AGS2) (Deleted in lymphocytic leukemia 8) (Ribonuclease HI subunit B) | UniProt NCBI |
| CHMP2B | Charged multivesicular body protein 2b (CHMP2.5) (Chromatin-modifying protein 2b) (CHMP2b) (Vacuolar protein sorting-associated protein 2-2) (Vps2-2) (hVps2-2) | UniProt NCBI |
| SETD3 | Actin-histidine N-methyltransferase (EC 2.1.1.85) (SET domain-containing protein 3) (hSETD3) | UniProt NCBI |
| VAT1 | Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0002371 | 0.0003973269126 | 0.375 | RNASEH2A RNASEH2B CHMP2B | Loss of speech |
| HP:0002180 | 0.00315443340696 | 0.375 | RNASEH2A RNASEH2B CHMP2B | Neurodegeneration |
| HP:0003552 | 0.00329918963144 | 0.375 | RNASEH2A RNASEH2B SPAST | Muscle stiffness |
| HP:0200149 | 0.00348326758344 | 0.25 | RNASEH2A RNASEH2B | CSF lymphocytic pleiocytosis |
| HP:0030356 | 0.00348326758344 | 0.25 | RNASEH2A RNASEH2B | Increased serum interferon-gamma level |
| HP:0012229 | 0.00348326758344 | 0.25 | RNASEH2A RNASEH2B | CSF pleocytosis |
| HP:0009710 | 0.00348326758344 | 0.25 | RNASEH2A RNASEH2B | Chilblains |
| HP:0009709 | 0.00348326758344 | 0.25 | RNASEH2A RNASEH2B | Increased CSF interferon alpha |
| HP:0009704 | 0.00348326758344 | 0.25 | RNASEH2A RNASEH2B | Chronic CSF lymphocytosis |
| HP:0040140 | 0.00464310919637 | 0.25 | RNASEH2A RNASEH2B | Degeneration of the striatum |
| HP:0005550 | 0.00464310919637 | 0.25 | RNASEH2A RNASEH2B | Chronic lymphatic leukemia |
| HP:0001955 | 0.00464310919637 | 0.25 | RNASEH2A RNASEH2B | Unexplained fevers |
| HP:0030354 | 0.0059681081945 | 0.25 | RNASEH2A RNASEH2B | Abnormal serum interferon level |
| HP:0030355 | 0.0059681081945 | 0.25 | RNASEH2A RNASEH2B | Abnormal serum interferon-gamma level |
| HP:0007256 | 0.00697150228022 | 0.5 | RNASEH2A RNASEH2B SPAST CHMP2B | Abnormal pyramidal sign |
| HP:0007052 | 0.00745813121128 | 0.25 | RNASEH2A RNASEH2B | Multifocal cerebral white matter abnormalities |
| HP:0011834 | 0.00745813121128 | 0.25 | RNASEH2A RNASEH2B | Moyamoya phenomenon |
| KEGG:03030 | 0.00757711563585 | 0.25 | RNASEH2A RNASEH2B | DNA replication |
| HP:0004809 | 0.0109327161708 | 0.25 | RNASEH2A RNASEH2B | Neonatal alloimmune thrombocytopenia |
| HP:0100851 | 0.0121058410113 | 0.5 | RNASEH2A RNASEH2B SPAST CHMP2B | Abnormal emotion/affect behavior |
| HP:0007076 | 0.0129170117165 | 0.25 | RNASEH2A RNASEH2B | Extrapyramidal muscular rigidity |
| HP:0003683 | 0.0129170117165 | 0.25 | RNASEH2A RNASEH2B | Large beaked nose |
| HP:0011112 | 0.0150657984869 | 0.25 | RNASEH2A RNASEH2B | Abnormality of serum cytokine level |
| HP:0030038 | 0.0173789434513 | 0.25 | RNASEH2A RNASEH2B | Enchondroma |
| HP:0011111 | 0.0173789434513 | 0.25 | RNASEH2A RNASEH2B | Abnormality of immune serum protein physiology |
| HP:0005558 | 0.0198563136463 | 0.25 | RNASEH2A RNASEH2B | Chronic leukemia |
| HP:0004963 | 0.0198563136463 | 0.25 | RNASEH2A RNASEH2B | Calcification of the aorta |
| HP:0000737 | 0.0216216055076 | 0.375 | RNASEH2A RNASEH2B CHMP2B | Irritability |
| HP:0030880 | 0.0253031982095 | 0.25 | RNASEH2A RNASEH2B | Raynaud phenomenon |
| HP:0012490 | 0.0314053898103 | 0.25 | RNASEH2A RNASEH2B | Panniculitis |
| HP:0001348 | 0.0314053898103 | 0.25 | SPAST CHMP2B | Brisk reflexes |
| HP:0002063 | 0.034152866599 | 0.375 | RNASEH2A RNASEH2B CHMP2B | Rigidity |
| HP:0001063 | 0.0347018940535 | 0.25 | RNASEH2A RNASEH2B | Acrocyanosis |
| GO:0032299 | 0.0378589948753 | 0.25 | RNASEH2A RNASEH2B | ribonuclease H2 complex |
| HP:0002061 | 0.0430873277361 | 0.375 | RNASEH2A RNASEH2B SPAST | Lower limb spasticity |
| HP:0003207 | 0.0455714500205 | 0.25 | RNASEH2A RNASEH2B | Arterial calcification |
| HP:0002132 | 0.0495208749973 | 0.25 | RNASEH2A RNASEH2B | Porencephalic cyst |
| HP:0004934 | 0.0495208749973 | 0.25 | RNASEH2A RNASEH2B | Vascular calcification |
| CORUM:6569 | 0.0497224828424 | 0.125 | SPAST | SPG4-SPG33 complex |
| CORUM:6615 | 0.0497224828424 | 0.125 | SPAST | SPG4-SPG12 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RNASEH2B | RNASEH2A | 1.0 | 0.949 | hein_WMM hein (RNASEH2A,RNASEH2B) fraction |
| CMTR1 | SETD3 | 0.148 | 0.409 | fraction |
| SETD3 | RNASEH2A | 0.108 | 0.373 | fraction |
| RNASEH2B | SETD3 | 0.064 | 0.349 | fraction |
| SPAST | RNASEH2B | 0.043 | 0.269 | fraction |
| CMTR1 | RNASEH2A | 0.041 | 0.27 | youn_WMM fraction |
| RNASEH2A | CHID1 | 0.037 | 0.265 | bioplex_WMM fraction |
| RNASEH2A | VAT1 | 0.026 | 0.22 | bioplex_WMM fraction |
| RNASEH2B | CHID1 | 0.023 | 0.206 | fraction |
| CHMP2B | CHID1 | 0.02 | 0.185 | bioplex_WMM fraction |
| RNASEH2B | CHMP2B | 0.013 | 0.15 | fraction |
| RNASEH2B | VAT1 | 0.008 | 0.085 | fraction |
| SPAST | CMTR1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| CMTR1 | VAT1 | 0.007 | 0.002 | bioplex_WMM gupta_WMM WMM_only |
| SPAST | RNASEH2A | 0.005 | 0.007 | fraction |
| RNASEH2A | CHMP2B | 0.005 | 0.006 | bioplex_WMM youn_WMM fraction |
| CHMP2B | VAT1 | 0.005 | 0.009 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RNASEH2B | CMTR1 | 0.004 | 0.013 | fraction |
| SPAST | SETD3 | 0.004 | 0.012 | fraction |
| CMTR1 | CHMP2B | 0.0 | 0.015 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SPAST | CHID1 | 0.0 | 0.011 | fraction |
| SPAST | CHMP2B | 0.0 | 0.006 | hein_WMM bioplex_WMM youn_WMM hein (SPAST) fraction |
| SETD3 | VAT1 | 0.0 | 0.0 | fraction |
Images
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Complex HuMAP2_05586 has an average edge precision of 0.166 which is ranked 6568 out of all 6965 complexes.
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