hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05614
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NELFCD | Negative elongation factor C/D (NELF-C/D) (TH1-like protein) | UniProt NCBI |
| IGHMBP2 | DNA-binding protein SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent helicase IGHMBP2) (Glial factor 1) (GF-1) (Immunoglobulin mu-binding protein 2) | UniProt NCBI |
| NELFA | Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein) | UniProt NCBI |
| NELFB | Negative elongation factor B (NELF-B) (Cofactor of BRCA1) | UniProt NCBI |
| NELFE | Negative elongation factor E (NELF-E) (RNA-binding protein RD) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:281 | 1.81514593393e-13 | 0.8 | NELFE NELFA NELFB NELFCD | NELF complex (Negative elongation factor complex) |
| CORUM:2598 | 1.81514593393e-13 | 0.8 | NELFE NELFA NELFB NELFCD | NELF complex (Negative elongation factor complex) |
| GO:0032021 | 1.2197780676e-10 | 0.8 | NELFE NELFA NELFB NELFCD | NELF complex |
| WP:WP3414 | 2.47269051758e-09 | 0.8 | NELFE NELFA NELFB NELFCD | Initiation of transcription and translation elongation at the HIV-1 LTR |
| REAC:R-HSA-167242 | 3.2305714914e-09 | 0.8 | NELFE NELFA NELFB NELFCD | Abortive elongation of HIV-1 transcript in the absence of Tat |
| REAC:R-HSA-167238 | 1.31129440131e-08 | 0.8 | NELFE NELFA NELFB NELFCD | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-167243 | 1.31129440131e-08 | 0.8 | NELFE NELFA NELFB NELFCD | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167158 | 1.49208230389e-08 | 0.8 | NELFE NELFA NELFB NELFCD | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-113418 | 1.49208230389e-08 | 0.8 | NELFE NELFA NELFB NELFCD | Formation of the Early Elongation Complex |
| GO:0034244 | 1.53650749201e-08 | 0.8 | NELFE NELFA NELFB NELFCD | negative regulation of transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-167290 | 1.69093561494e-08 | 0.8 | NELFE NELFA NELFB NELFCD | Pausing and recovery of HIV elongation |
| REAC:R-HSA-167287 | 1.69093561494e-08 | 0.8 | NELFE NELFA NELFB NELFCD | HIV elongation arrest and recovery |
| GO:0032785 | 4.0237537548e-08 | 0.8 | NELFE NELFA NELFB NELFCD | negative regulation of DNA-templated transcription, elongation |
| REAC:R-HSA-167169 | 4.94701294863e-08 | 0.8 | NELFE NELFA NELFB NELFCD | HIV Transcription Elongation |
| REAC:R-HSA-167246 | 4.94701294863e-08 | 0.8 | NELFE NELFA NELFB NELFCD | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167200 | 4.94701294863e-08 | 0.8 | NELFE NELFA NELFB NELFCD | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167152 | 5.94611734259e-08 | 0.8 | NELFE NELFA NELFB NELFCD | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-75955 | 1.65722225947e-07 | 0.8 | NELFE NELFA NELFB NELFCD | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-112382 | 1.65722225947e-07 | 0.8 | NELFE NELFA NELFB NELFCD | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-6796648 | 2.03091825402e-07 | 0.8 | NELFE NELFA NELFB NELFCD | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-167172 | 3.53566687566e-07 | 0.8 | NELFE NELFA NELFB NELFCD | Transcription of the HIV genome |
| REAC:R-HSA-674695 | 6.36085103797e-07 | 0.8 | NELFE NELFA NELFB NELFCD | RNA Polymerase II Pre-transcription Events |
| GO:0034243 | 2.13806517127e-06 | 0.8 | NELFE NELFA NELFB NELFCD | regulation of transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-162599 | 4.51796469523e-06 | 0.8 | NELFE NELFA NELFB NELFCD | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 6.58288761159e-06 | 0.8 | NELFE NELFA NELFB NELFCD | HIV Life Cycle |
| GO:0050434 | 1.11259903434e-05 | 0.8 | NELFE NELFA NELFB NELFCD | positive regulation of viral transcription |
| GO:0032784 | 1.98600319243e-05 | 0.8 | NELFE NELFA NELFB NELFCD | regulation of DNA-templated transcription, elongation |
| GO:0008023 | 2.802206198e-05 | 0.8 | NELFE NELFA NELFB NELFCD | transcription elongation factor complex |
| REAC:R-HSA-162906 | 3.61955824501e-05 | 0.8 | NELFE NELFA NELFB NELFCD | HIV Infection |
| GO:0046782 | 5.53512234664e-05 | 0.8 | NELFE NELFA NELFB NELFCD | regulation of viral transcription |
| GO:0006368 | 0.000182533273841 | 0.8 | NELFE NELFA NELFB NELFCD | transcription elongation from RNA polymerase II promoter |
| REAC:R-HSA-3700989 | 0.00021529066689 | 0.8 | NELFE NELFA NELFB NELFCD | Transcriptional Regulation by TP53 |
| REAC:R-HSA-5663205 | 0.000241108816086 | 0.8 | NELFE NELFA NELFB NELFCD | Infectious disease |
| GO:0048524 | 0.000403202499238 | 0.8 | NELFE NELFA NELFB NELFCD | positive regulation of viral process |
| GO:0006354 | 0.0005799178998 | 0.8 | NELFE NELFA NELFB NELFCD | DNA-templated transcription, elongation |
| GO:0000122 | 0.00356243234137 | 1.0 | NELFCD IGHMBP2 NELFE NELFB NELFA | negative regulation of transcription by RNA polymerase II |
| GO:0019083 | 0.00415715596103 | 0.8 | NELFE NELFA NELFB NELFCD | viral transcription |
| GO:0050792 | 0.00534283459488 | 0.8 | NELFE NELFA NELFB NELFCD | regulation of viral process |
| GO:0019080 | 0.00608750012464 | 0.8 | NELFE NELFA NELFB NELFCD | viral gene expression |
| GO:0043903 | 0.00705155239441 | 0.8 | NELFE NELFA NELFB NELFCD | regulation of symbiosis, encompassing mutualism through parasitism |
| REAC:R-HSA-1643685 | 0.0116415059931 | 0.8 | NELFE NELFA NELFB NELFCD | Disease |
| REAC:R-HSA-212436 | 0.0163364711391 | 0.8 | NELFE NELFA NELFB NELFCD | Generic Transcription Pathway |
| REAC:R-HSA-73857 | 0.0251017869848 | 0.8 | NELFE NELFA NELFB NELFCD | RNA Polymerase II Transcription |
| GO:0045892 | 0.0328678033498 | 1.0 | NELFCD IGHMBP2 NELFE NELFB NELFA | negative regulation of transcription, DNA-templated |
| GO:1903507 | 0.0332499840271 | 1.0 | NELFCD IGHMBP2 NELFE NELFB NELFA | negative regulation of nucleic acid-templated transcription |
| GO:1902679 | 0.0334424029162 | 1.0 | NELFCD IGHMBP2 NELFE NELFB NELFA | negative regulation of RNA biosynthetic process |
| REAC:R-HSA-74160 | 0.038571388232 | 0.8 | NELFE NELFA NELFB NELFCD | Gene expression (Transcription) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NELFB | NELFE | 1.0 | 0.949 | hein_WMM bioplex (NELFE) bioplex_WMM youn_WMM hein (NELFE) gupta_WMM fraction |
| NELFE | NELFA | 1.0 | 0.949 | hein_WMM bioplex (NELFA,NELFE) bioplex_WMM youn_WMM hein (NELFA,NELFE) gupta_WMM |
| NELFE | NELFCD | 0.999 | 0.949 | hein_WMM bioplex (NELFE) bioplex_WMM youn_WMM hein (NELFE) gupta_WMM fraction |
| NELFB | NELFA | 0.994 | 0.923 | hein_WMM bioplex (NELFA) bioplex_WMM youn_WMM hein (NELFA) |
| NELFA | NELFCD | 0.972 | 0.886 | hein_WMM bioplex (NELFA) bioplex_WMM youn_WMM hein (NELFA) |
| NELFE | IGHMBP2 | 0.713 | 0.727 | bioplex (NELFE) bioplex_WMM |
| IGHMBP2 | NELFA | 0.043 | 0.269 | bioplex (NELFA) bioplex_WMM |
| NELFB | NELFCD | 0.016 | 0.16 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| IGHMBP2 | NELFCD | 0.011 | 0.144 | bioplex_WMM WMM_only |
| NELFB | IGHMBP2 | 0.011 | 0.144 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05614 has an average edge precision of 0.61 which is ranked 1890 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NELFCD | HuMAP2_04651 HuMAP2_05614 HuMAP2_06018 |
| IGHMBP2 | HuMAP2_04651 HuMAP2_05614 HuMAP2_06018 |
| NELFA | HuMAP2_04651 HuMAP2_05614 HuMAP2_06018 |
| NELFB | HuMAP2_01553 HuMAP2_04054 HuMAP2_04651 HuMAP2_05614 HuMAP2_06018 |
| NELFE | HuMAP2_04054 HuMAP2_04651 HuMAP2_05614 HuMAP2_06018 |