hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05623
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APTX | Aprataxin (EC 3.1.11.7) (EC 3.1.12.2) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT) | UniProt NCBI |
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | UniProt NCBI |
| PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:362 | 1.81514593393e-13 | 0.8 | POLB XRCC1 PNKP LIG3 | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| REAC:R-HSA-5649702 | 5.47745657224e-12 | 0.8 | POLB XRCC1 PNKP LIG3 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| CORUM:1086 | 5.40532307664e-09 | 0.6 | POLB XRCC1 LIG3 | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| CORUM:5243 | 5.40532307664e-09 | 0.6 | XRCC1 PNKP LIG3 | XRCC1-LIG3-PNK-TDP1 complex |
| REAC:R-HSA-110381 | 1.08753805614e-08 | 0.6 | POLB XRCC1 LIG3 | Resolution of AP sites via the single-nucleotide replacement pathway |
| CORUM:1085 | 1.35119464053e-08 | 0.6 | POLB XRCC1 LIG3 | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-73933 | 1.90901811802e-08 | 0.8 | POLB XRCC1 PNKP LIG3 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-73884 | 8.09278526697e-07 | 0.8 | POLB XRCC1 PNKP LIG3 | Base Excision Repair |
| GO:0006288 | 9.08185760231e-07 | 0.6 | POLB XRCC1 LIG3 | base-excision repair, DNA ligation |
| KEGG:03410 | 4.27757362181e-06 | 0.6 | POLB XRCC1 LIG3 | Base excision repair |
| CORUM:212 | 6.70868171695e-06 | 0.4 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:363 | 6.70868171695e-06 | 0.4 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 6.70868171695e-06 | 0.4 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| GO:0051103 | 5.0832789986e-05 | 0.6 | POLB XRCC1 LIG3 | DNA ligation involved in DNA repair |
| HPA:035010_13 | 0.000134753537676 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; decidual cells[Supported,High] |
| HPA:014020_13 | 0.000149219334689 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; glandular cells[Supported,High] |
| REAC:R-HSA-73894 | 0.00015586029631 | 0.8 | POLB XRCC1 PNKP LIG3 | DNA Repair |
| HPA:009010_13 | 0.000201976503664 | 0.8 | XRCC1 PNKP APTX LIG3 | cervix, uterine; glandular cells[Supported,High] |
| HPA:013020_13 | 0.000211560879257 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; glandular cells[Supported,High] |
| HPA:044010_13 | 0.000300989329961 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 2; epidermal cells[Supported,High] |
| HP:0000570 | 0.000334999316862 | 0.6 | XRCC1 APTX PNKP | Abnormal saccadic eye movements |
| HPA:008030_13 | 0.000424183171368 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; neuronal cells[Supported,High] |
| HPA:015010_13 | 0.000449321302059 | 0.8 | XRCC1 PNKP APTX LIG3 | epididymis; glandular cells[Supported,High] |
| GO:0006266 | 0.000507918241599 | 0.6 | POLB XRCC1 LIG3 | DNA ligation |
| HP:0000657 | 0.000602597659635 | 0.6 | XRCC1 APTX PNKP | Oculomotor apraxia |
| REAC:R-HSA-5685939 | 0.000606744453221 | 0.4 | XRCC1 LIG3 | HDR through MMEJ (alt-NHEJ) |
| HPA:055010_13 | 0.000613409956715 | 0.8 | XRCC1 PNKP APTX LIG3 | thyroid gland; glandular cells[Supported,High] |
| HPA:053020_13 | 0.000618828417899 | 0.8 | XRCC1 PNKP APTX LIG3 | testis; cells in seminiferous ducts[Supported,High] |
| HPA:014010_12 | 0.000686676246796 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; cells in endometrial stroma[Supported,Medium] |
| HPA:035010_03 | 0.00069257049577 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; decidual cells[Uncertain,High] |
| HPA:057010_13 | 0.000698502442914 | 0.8 | XRCC1 PNKP APTX LIG3 | urinary bladder; urothelial cells[Supported,High] |
| HPA:032010_13 | 0.000766287528839 | 0.8 | XRCC1 PNKP APTX LIG3 | pancreas; exocrine glandular cells[Supported,High] |
| HPA:029010_13 | 0.000811906226014 | 0.8 | XRCC1 PNKP APTX LIG3 | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.000818584935003 | 0.8 | XRCC1 PNKP APTX LIG3 | bronchus; respiratory epithelial cells[Supported,High] |
| HPA:035020_13 | 0.00103075055401 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; trophoblastic cells[Supported,High] |
| HPA:013010_12 | 0.00105482772918 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; cells in endometrial stroma[Supported,Medium] |
| HPA:009010_03 | 0.00111263875785 | 0.8 | XRCC1 PNKP APTX LIG3 | cervix, uterine; glandular cells[Uncertain,High] |
| HPA:014020_03 | 0.00112958191317 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; glandular cells[Uncertain,High] |
| HPA:037010_13 | 0.00128148731175 | 0.8 | XRCC1 PNKP APTX LIG3 | rectum; glandular cells[Supported,High] |
| GO:0006281 | 0.00130222282902 | 1.0 | POLB XRCC1 PNKP APTX LIG3 | DNA repair |
| HPA:013020_03 | 0.00134827116423 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; glandular cells[Uncertain,High] |
| HPA:035010_12 | 0.00158609289926 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; decidual cells[Supported,Medium] |
| HPA:024010_12 | 0.00182934994206 | 0.8 | XRCC1 PNKP APTX LIG3 | kidney; cells in glomeruli[Supported,Medium] |
| HPA:044010_03 | 0.00187866612392 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 2; epidermal cells[Uncertain,High] |
| HPA:050010_12 | 0.00198026540152 | 0.8 | XRCC1 PNKP APTX LIG3 | spleen; cells in red pulp[Supported,Medium] |
| HPA:027020_12 | 0.00203257423209 | 0.8 | XRCC1 PNKP APTX LIG3 | lung; pneumocytes[Supported,Medium] |
| HPA:041010_12 | 0.00216785233947 | 0.8 | XRCC1 PNKP APTX LIG3 | skeletal muscle; myocytes[Supported,Medium] |
| HPA:011010_12 | 0.00222380043501 | 0.8 | XRCC1 PNKP APTX LIG3 | colon; endothelial cells[Supported,Medium] |
| HPA:007030_12 | 0.00222380043501 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; cells in molecular layer[Supported,Medium] |
| HPA:043020_12 | 0.00229524105743 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; fibroblasts[Supported,Medium] |
| HPA:006020_12 | 0.00232429103223 | 0.8 | XRCC1 PNKP APTX LIG3 | caudate; neuronal cells[Supported,Medium] |
| HPA:014010_11 | 0.00281055172522 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; cells in endometrial stroma[Supported,Low] |
| HPA:022020_12 | 0.00281055172522 | 0.8 | XRCC1 PNKP APTX LIG3 | hippocampus; neuronal cells[Supported,Medium] |
| HPA:004030_12 | 0.00293009065042 | 0.8 | XRCC1 PNKP APTX LIG3 | breast; myoepithelial cells[Supported,Medium] |
| HPA:043040_12 | 0.0030533778206 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; melanocytes[Supported,Medium] |
| HPA:008030_03 | 0.00312553982722 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; neuronal cells[Uncertain,High] |
| HPA:007010_12 | 0.00316209360459 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; Purkinje cells[Supported,Medium] |
| HPA:035010_11 | 0.00318048947277 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; decidual cells[Supported,Low] |
| HPA:009010_12 | 0.00321752029433 | 0.8 | XRCC1 PNKP APTX LIG3 | cervix, uterine; glandular cells[Supported,Medium] |
| HP:0002186 | 0.00330690735156 | 0.6 | XRCC1 APTX PNKP | Apraxia |
| HPA:015010_03 | 0.00348580573423 | 0.8 | XRCC1 PNKP APTX LIG3 | epididymis; glandular cells[Uncertain,High] |
| HPA:058010_12 | 0.00366685344616 | 0.8 | XRCC1 PNKP APTX LIG3 | vagina; squamous epithelial cells[Supported,Medium] |
| HPA:003010_12 | 0.00372873057472 | 0.8 | XRCC1 PNKP APTX LIG3 | bone marrow; hematopoietic cells[Supported,Medium] |
| HPA:056020_12 | 0.00381243915783 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; non-germinal center cells[Supported,Medium] |
| HPA:056010_12 | 0.00381243915783 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; germinal center cells[Supported,Medium] |
| HPA:043030_12 | 0.00387613310206 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; keratinocytes[Supported,Medium] |
| HPA:031020_11 | 0.00398404661073 | 0.8 | XRCC1 PNKP APTX LIG3 | ovary; ovarian stroma cells[Supported,Low] |
| REAC:R-HSA-5696397 | 0.0040368179849 | 0.4 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| HPA:036010_12 | 0.0044146345579 | 0.8 | XRCC1 PNKP APTX LIG3 | prostate; glandular cells[Supported,Medium] |
| HPA:014020_12 | 0.0044146345579 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; glandular cells[Supported,Medium] |
| HPA:056030_12 | 0.0044146345579 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; squamous epithelial cells[Supported,Medium] |
| HPA:030010_12 | 0.00446189292164 | 0.8 | XRCC1 PNKP APTX LIG3 | oral mucosa; squamous epithelial cells[Supported,Medium] |
| HPA:013010_11 | 0.00453348544726 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; cells in endometrial stroma[Supported,Low] |
| HPA:008030_12 | 0.00455753859173 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; neuronal cells[Supported,Medium] |
| HPA:039010_12 | 0.00472858128385 | 0.8 | XRCC1 PNKP APTX LIG3 | salivary gland; glandular cells[Supported,Medium] |
| HPA:007020_11 | 0.00482843997673 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; cells in granular layer[Supported,Low] |
| HPA:008020_11 | 0.00490435791149 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; glial cells[Supported,Low] |
| HPA:053020_03 | 0.00500695977858 | 0.8 | XRCC1 PNKP APTX LIG3 | testis; cells in seminiferous ducts[Uncertain,High] |
| HPA:055010_03 | 0.00500695977858 | 0.8 | XRCC1 PNKP APTX LIG3 | thyroid gland; glandular cells[Uncertain,High] |
| HPA:013020_12 | 0.00508495336202 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; glandular cells[Supported,Medium] |
| HPA:043020_11 | 0.00508495336202 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; fibroblasts[Supported,Low] |
| HPA:014010_02 | 0.00516384774562 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; cells in endometrial stroma[Uncertain,Medium] |
| HPA:057010_03 | 0.00521694779089 | 0.8 | XRCC1 PNKP APTX LIG3 | urinary bladder; urothelial cells[Uncertain,High] |
| HPA:028010_11 | 0.005270453216 | 0.8 | XRCC1 PNKP APTX LIG3 | lymph node; germinal center cells[Supported,Low] |
| HPA:040010_12 | 0.00551629841826 | 0.8 | XRCC1 PNKP APTX LIG3 | seminal vesicle; glandular cells[Supported,Medium] |
| HPA:002020_11 | 0.00554413182777 | 0.8 | XRCC1 PNKP APTX LIG3 | appendix; lymphoid tissue[Supported,Low] |
| HPA:024010_11 | 0.00554413182777 | 0.8 | XRCC1 PNKP APTX LIG3 | kidney; cells in glomeruli[Supported,Low] |
| HPA:007030_11 | 0.00562825941284 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; cells in molecular layer[Supported,Low] |
| HPA:016010_12 | 0.0056565119128 | 0.8 | XRCC1 PNKP APTX LIG3 | esophagus; squamous epithelial cells[Supported,Medium] |
| HPA:006020_11 | 0.0056565119128 | 0.8 | XRCC1 PNKP APTX LIG3 | caudate; neuronal cells[Supported,Low] |
| HPA:032020_11 | 0.00568486982566 | 0.8 | XRCC1 PNKP APTX LIG3 | pancreas; islets of Langerhans[Supported,Low] |
| HPA:004030_13 | 0.00570992332484 | 0.6 | XRCC1 PNKP LIG3 | breast; myoepithelial cells[Supported,High] |
| HPA:044010_12 | 0.0057133334081 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 2; epidermal cells[Supported,Medium] |
| HPA:032010_03 | 0.0057419029171 | 0.8 | XRCC1 PNKP APTX LIG3 | pancreas; exocrine glandular cells[Uncertain,High] |
| HPA:004020_12 | 0.00594487706918 | 0.8 | XRCC1 PNKP APTX LIG3 | breast; glandular cells[Supported,Medium] |
| HPA:011010_11 | 0.00597430327586 | 0.8 | XRCC1 PNKP APTX LIG3 | colon; endothelial cells[Supported,Low] |
| HPA:009010_11 | 0.00600383773468 | 0.8 | XRCC1 PNKP APTX LIG3 | cervix, uterine; glandular cells[Supported,Low] |
| HPA:041010_11 | 0.0060930932237 | 0.8 | XRCC1 PNKP APTX LIG3 | skeletal muscle; myocytes[Supported,Low] |
| HPA:015010_12 | 0.00630519349332 | 0.8 | XRCC1 PNKP APTX LIG3 | epididymis; glandular cells[Supported,Medium] |
| HPA:055010_12 | 0.00633593593681 | 0.8 | XRCC1 PNKP APTX LIG3 | thyroid gland; glandular cells[Supported,Medium] |
| HPA:053020_12 | 0.00633593593681 | 0.8 | XRCC1 PNKP APTX LIG3 | testis; cells in seminiferous ducts[Supported,Medium] |
| HPA:050010_11 | 0.00633593593681 | 0.8 | XRCC1 PNKP APTX LIG3 | spleen; cells in red pulp[Supported,Low] |
| HPA:004030_11 | 0.00636678976911 | 0.8 | XRCC1 PNKP APTX LIG3 | breast; myoepithelial cells[Supported,Low] |
| HPA:032010_12 | 0.00639775525348 | 0.8 | XRCC1 PNKP APTX LIG3 | pancreas; exocrine glandular cells[Supported,Medium] |
| HPA:027020_11 | 0.00642883265342 | 0.8 | XRCC1 PNKP APTX LIG3 | lung; pneumocytes[Supported,Low] |
| HPA:043040_11 | 0.00642883265342 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; melanocytes[Supported,Low] |
| HPA:001040_12 | 0.00642883265342 | 0.8 | XRCC1 PNKP APTX LIG3 | adrenal gland; glandular cells[Supported,Medium] |
| HPA:002010_12 | 0.00652273898617 | 0.8 | XRCC1 PNKP APTX LIG3 | appendix; glandular cells[Supported,Medium] |
| HPA:035020_12 | 0.00652273898617 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; trophoblastic cells[Supported,Medium] |
| HPA:007010_11 | 0.00661766207304 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; Purkinje cells[Supported,Low] |
| HPA:029010_12 | 0.00664953028439 | 0.8 | XRCC1 PNKP APTX LIG3 | nasopharynx; respiratory epithelial cells[Supported,Medium] |
| HPA:022020_11 | 0.00674582018662 | 0.8 | XRCC1 PNKP APTX LIG3 | hippocampus; neuronal cells[Supported,Low] |
| HPA:043020_13 | 0.0070287335521 | 0.6 | XRCC1 PNKP LIG3 | skin 1; fibroblasts[Supported,High] |
| HPA:021010_11 | 0.0074145140339 | 0.8 | XRCC1 PNKP APTX LIG3 | heart muscle; myocytes[Supported,Low] |
| HPA:056010_11 | 0.00744919306569 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; germinal center cells[Supported,Low] |
| HPA:028020_11 | 0.00758911689647 | 0.8 | XRCC1 PNKP APTX LIG3 | lymph node; non-germinal center cells[Supported,Low] |
| GO:0006284 | 0.00763446836913 | 0.6 | POLB XRCC1 LIG3 | base-excision repair |
| HPA:005010_12 | 0.00765980726047 | 0.8 | XRCC1 PNKP APTX LIG3 | bronchus; respiratory epithelial cells[Supported,Medium] |
| HPA:011020_12 | 0.00765980726047 | 0.8 | XRCC1 PNKP APTX LIG3 | colon; glandular cells[Supported,Medium] |
| HPA:052010_12 | 0.00765980726047 | 0.8 | XRCC1 PNKP APTX LIG3 | stomach 2; glandular cells[Supported,Medium] |
| HPA:057010_12 | 0.00765980726047 | 0.8 | XRCC1 PNKP APTX LIG3 | urinary bladder; urothelial cells[Supported,Medium] |
| HPA:056030_11 | 0.00769533551318 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; squamous epithelial cells[Supported,Low] |
| HPA:029010_03 | 0.00769533551318 | 0.8 | XRCC1 PNKP APTX LIG3 | nasopharynx; respiratory epithelial cells[Uncertain,High] |
| HPA:018010_12 | 0.00769533551318 | 0.8 | XRCC1 PNKP APTX LIG3 | fallopian tube; glandular cells[Supported,Medium] |
| HPA:051010_12 | 0.00787481847255 | 0.8 | XRCC1 PNKP APTX LIG3 | stomach 1; glandular cells[Supported,Medium] |
| HPA:058010_11 | 0.00787481847255 | 0.8 | XRCC1 PNKP APTX LIG3 | vagina; squamous epithelial cells[Supported,Low] |
| HPA:024020_12 | 0.00794747625541 | 0.8 | XRCC1 PNKP APTX LIG3 | kidney; cells in tubules[Supported,Medium] |
| HPA:008030_11 | 0.00805739619047 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; neuronal cells[Supported,Low] |
| HPA:045010_12 | 0.00805739619047 | 0.8 | XRCC1 PNKP APTX LIG3 | small intestine; glandular cells[Supported,Medium] |
| HPA:043030_11 | 0.00813130155293 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; keratinocytes[Supported,Low] |
| HPA:035020_03 | 0.00816844268861 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; trophoblastic cells[Uncertain,High] |
| HPA:056020_11 | 0.00816844268861 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; non-germinal center cells[Supported,Low] |
| HPA:037010_12 | 0.00820570983136 | 0.8 | XRCC1 PNKP APTX LIG3 | rectum; glandular cells[Supported,Medium] |
| HPA:005010_03 | 0.00824310325957 | 0.8 | XRCC1 PNKP APTX LIG3 | bronchus; respiratory epithelial cells[Uncertain,High] |
| HPA:030010_11 | 0.00835604404537 | 0.8 | XRCC1 PNKP APTX LIG3 | oral mucosa; squamous epithelial cells[Supported,Low] |
| HPA:019010_12 | 0.00847013145002 | 0.8 | XRCC1 PNKP APTX LIG3 | gallbladder; glandular cells[Supported,Medium] |
| HPA:012010_12 | 0.00847013145002 | 0.8 | XRCC1 PNKP APTX LIG3 | duodenum; glandular cells[Supported,Medium] |
| HPA:014020_11 | 0.00847013145002 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; glandular cells[Supported,Low] |
| HPA:003010_11 | 0.00854683046377 | 0.8 | XRCC1 PNKP APTX LIG3 | bone marrow; hematopoietic cells[Supported,Low] |
| HPA:027010_11 | 0.00854683046377 | 0.8 | XRCC1 PNKP APTX LIG3 | lung; macrophages[Supported,Low] |
| HPA:036010_11 | 0.00862404469264 | 0.8 | XRCC1 PNKP APTX LIG3 | prostate; glandular cells[Supported,Low] |
| HPA:039010_11 | 0.00878002780279 | 0.8 | XRCC1 PNKP APTX LIG3 | salivary gland; glandular cells[Supported,Low] |
| HPA:040010_11 | 0.00885880119868 | 0.8 | XRCC1 PNKP APTX LIG3 | seminal vesicle; glandular cells[Supported,Low] |
| HPA:013010_02 | 0.00889838434658 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; cells in endometrial stroma[Uncertain,Medium] |
| HPA:013020_11 | 0.00897794495935 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; glandular cells[Supported,Low] |
| HPA:029010_11 | 0.00913865140563 | 0.8 | XRCC1 PNKP APTX LIG3 | nasopharynx; respiratory epithelial cells[Supported,Low] |
| HPA:055010_11 | 0.00913865140563 | 0.8 | XRCC1 PNKP APTX LIG3 | thyroid gland; glandular cells[Supported,Low] |
| HPA:004020_11 | 0.00913865140563 | 0.8 | XRCC1 PNKP APTX LIG3 | breast; glandular cells[Supported,Low] |
| HPA:016010_11 | 0.0091791599316 | 0.8 | XRCC1 PNKP APTX LIG3 | esophagus; squamous epithelial cells[Supported,Low] |
| HPA:044010_11 | 0.0092198017936 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 2; epidermal cells[Supported,Low] |
| HPA:002010_11 | 0.00938370831845 | 0.8 | XRCC1 PNKP APTX LIG3 | appendix; glandular cells[Supported,Low] |
| HP:0003474 | 0.00938943928499 | 0.6 | XRCC1 APTX PNKP | Sensory impairment |
| HPA:032010_11 | 0.0095080522633 | 0.8 | XRCC1 PNKP APTX LIG3 | pancreas; exocrine glandular cells[Supported,Low] |
| HPA:043040_13 | 0.00951247038188 | 0.6 | XRCC1 APTX LIG3 | skin 1; melanocytes[Supported,High] |
| HPA:001040_11 | 0.00963361686817 | 0.8 | XRCC1 PNKP APTX LIG3 | adrenal gland; glandular cells[Supported,Low] |
| HPA:035020_11 | 0.00980294859364 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; trophoblastic cells[Supported,Low] |
| HPA:018010_11 | 0.00984562492478 | 0.8 | XRCC1 PNKP APTX LIG3 | fallopian tube; glandular cells[Supported,Low] |
| HPA:053010_11 | 0.00984562492478 | 0.8 | XRCC1 PNKP APTX LIG3 | testis; Leydig cells[Supported,Low] |
| HPA:015010_11 | 0.0100177125409 | 0.8 | XRCC1 PNKP APTX LIG3 | epididymis; glandular cells[Supported,Low] |
| HPA:043030_13 | 0.0100279987441 | 0.6 | XRCC1 APTX LIG3 | skin 1; keratinocytes[Supported,High] |
| HPA:011020_11 | 0.0101482377951 | 0.8 | XRCC1 PNKP APTX LIG3 | colon; glandular cells[Supported,Low] |
| HPA:019010_11 | 0.010280022825 | 0.8 | XRCC1 PNKP APTX LIG3 | gallbladder; glandular cells[Supported,Low] |
| HPA:057010_11 | 0.010280022825 | 0.8 | XRCC1 PNKP APTX LIG3 | urinary bladder; urothelial cells[Supported,Low] |
| HPA:053020_11 | 0.010280022825 | 0.8 | XRCC1 PNKP APTX LIG3 | testis; cells in seminiferous ducts[Supported,Low] |
| HPA:005010_11 | 0.0103242324815 | 0.8 | XRCC1 PNKP APTX LIG3 | bronchus; respiratory epithelial cells[Supported,Low] |
| HPA:037010_11 | 0.0103685832823 | 0.8 | XRCC1 PNKP APTX LIG3 | rectum; glandular cells[Supported,Low] |
| HPA:051010_11 | 0.0105474037933 | 0.8 | XRCC1 PNKP APTX LIG3 | stomach 1; glandular cells[Supported,Low] |
| HPA:052010_11 | 0.0109119090849 | 0.8 | XRCC1 PNKP APTX LIG3 | stomach 2; glandular cells[Supported,Low] |
| HPA:012010_11 | 0.010958121527 | 0.8 | XRCC1 PNKP APTX LIG3 | duodenum; glandular cells[Supported,Low] |
| HPA:045010_11 | 0.0110509825229 | 0.8 | XRCC1 PNKP APTX LIG3 | small intestine; glandular cells[Supported,Low] |
| HPA:027020_13 | 0.0111136864674 | 0.6 | XRCC1 APTX PNKP | lung; pneumocytes[Supported,High] |
| HPA:024020_11 | 0.0116204846712 | 0.8 | XRCC1 PNKP APTX LIG3 | kidney; cells in tubules[Supported,Low] |
| GO:0006259 | 0.0122301485616 | 1.0 | POLB XRCC1 PNKP APTX LIG3 | DNA metabolic process |
| HP:0001284 | 0.0122356792032 | 0.6 | XRCC1 APTX PNKP | Areflexia |
| GO:0006974 | 0.0123166418329 | 1.0 | POLB XRCC1 PNKP APTX LIG3 | cellular response to DNA damage stimulus |
| HPA:035010_10 | 0.0125152537873 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; decidual cells[Supported,Not detected] |
| HPA:047040_12 | 0.0127599080481 | 0.6 | XRCC1 PNKP LIG3 | soft tissue 1; peripheral nerve[Supported,Medium] |
| GO:0006302 | 0.0134490676813 | 0.8 | POLB XRCC1 APTX LIG3 | double-strand break repair |
| GO:0098502 | 0.0135228859698 | 0.4 | POLB PNKP | DNA dephosphorylation |
| GO:0010836 | 0.0135228859698 | 0.4 | XRCC1 PNKP | negative regulation of protein ADP-ribosylation |
| HPA:037010_03 | 0.0149174122993 | 0.8 | XRCC1 PNKP APTX LIG3 | rectum; glandular cells[Uncertain,High] |
| HPA:058010_13 | 0.0151025190567 | 0.6 | XRCC1 APTX PNKP | vagina; squamous epithelial cells[Supported,High] |
| HPA:007030_13 | 0.0155185477857 | 0.6 | XRCC1 PNKP LIG3 | cerebellum; cells in molecular layer[Supported,High] |
| GO:0003684 | 0.0166549756635 | 0.6 | XRCC1 APTX PNKP | damaged DNA binding |
| HPA:004020_13 | 0.017108483906 | 0.6 | XRCC1 PNKP LIG3 | breast; glandular cells[Supported,High] |
| HPA:056030_13 | 0.0214571714536 | 0.6 | XRCC1 APTX LIG3 | tonsil; squamous epithelial cells[Supported,High] |
| HPA:027020_02 | 0.0234525212244 | 0.8 | XRCC1 PNKP APTX LIG3 | lung; pneumocytes[Uncertain,Medium] |
| HPA:039010_13 | 0.0236024900229 | 0.6 | XRCC1 APTX PNKP | salivary gland; glandular cells[Supported,High] |
| HPA:027020_03 | 0.0249166933231 | 0.6 | XRCC1 APTX PNKP | lung; pneumocytes[Uncertain,High] |
| HPA:004030_03 | 0.0249166933231 | 0.6 | XRCC1 PNKP LIG3 | breast; myoepithelial cells[Uncertain,High] |
| HPA:024010_02 | 0.0251233019505 | 0.8 | XRCC1 PNKP APTX LIG3 | kidney; cells in glomeruli[Uncertain,Medium] |
| HPA:009010_10 | 0.0257283998092 | 0.8 | XRCC1 PNKP APTX LIG3 | cervix, uterine; glandular cells[Supported,Not detected] |
| HPA:028010_10 | 0.0260789820994 | 0.8 | XRCC1 PNKP APTX LIG3 | lymph node; germinal center cells[Supported,Not detected] |
| HPA:047030_10 | 0.0263442329348 | 0.8 | XRCC1 PNKP APTX LIG3 | soft tissue 1; fibroblasts[Supported,Not detected] |
| HPA:050010_02 | 0.0265221741399 | 0.8 | XRCC1 PNKP APTX LIG3 | spleen; cells in red pulp[Uncertain,Medium] |
| HPA:056030_10 | 0.0267907540732 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; squamous epithelial cells[Supported,Not detected] |
| HPA:043030_03 | 0.0268762439476 | 0.6 | XRCC1 APTX LIG3 | skin 1; keratinocytes[Uncertain,High] |
| HPA:032020_10 | 0.0268807269841 | 0.8 | XRCC1 PNKP APTX LIG3 | pancreas; islets of Langerhans[Supported,Not detected] |
| HPA:048010_10 | 0.026970923626 | 0.8 | XRCC1 PNKP APTX LIG3 | soft tissue 2; adipocytes[Supported,Not detected] |
| HPA:002020_10 | 0.026970923626 | 0.8 | XRCC1 PNKP APTX LIG3 | appendix; lymphoid tissue[Supported,Not detected] |
| REAC:R-HSA-6782210 | 0.0269854937899 | 0.4 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| HP:0001272 | 0.0273340886952 | 0.6 | XRCC1 APTX PNKP | Cerebellar atrophy |
| HPA:004010_12 | 0.0274832454929 | 0.6 | LIG3 APTX PNKP | breast; adipocytes[Supported,Medium] |
| HPA:011010_10 | 0.0275168219532 | 0.8 | XRCC1 PNKP APTX LIG3 | colon; endothelial cells[Supported,Not detected] |
| HPA:029010_10 | 0.0277005942162 | 0.8 | XRCC1 PNKP APTX LIG3 | nasopharynx; respiratory epithelial cells[Supported,Not detected] |
| HPA:043020_03 | 0.0278928770515 | 0.6 | XRCC1 PNKP LIG3 | skin 1; fibroblasts[Uncertain,High] |
| HPA:003010_13 | 0.0280991888292 | 0.6 | XRCC1 PNKP LIG3 | bone marrow; hematopoietic cells[Supported,High] |
| HPA:053020_10 | 0.0282573698891 | 0.8 | XRCC1 PNKP APTX LIG3 | testis; cells in seminiferous ducts[Supported,Not detected] |
| HPA:006020_10 | 0.0282573698891 | 0.8 | XRCC1 PNKP APTX LIG3 | caudate; neuronal cells[Supported,Not detected] |
| HPA:007030_02 | 0.0285388462646 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; cells in molecular layer[Uncertain,Medium] |
| HPA:048030_10 | 0.0286331317025 | 0.8 | XRCC1 PNKP APTX LIG3 | soft tissue 2; fibroblasts[Supported,Not detected] |
| HPA:004010_10 | 0.029012583046 | 0.8 | XRCC1 PNKP APTX LIG3 | breast; adipocytes[Supported,Not detected] |
| HPA:002010_13 | 0.0293581469203 | 0.6 | XRCC1 APTX PNKP | appendix; glandular cells[Supported,High] |
| HPA:016010_13 | 0.0293581469203 | 0.6 | XRCC1 APTX PNKP | esophagus; squamous epithelial cells[Supported,High] |
| HPA:043040_03 | 0.0293581469203 | 0.6 | XRCC1 APTX LIG3 | skin 1; melanocytes[Uncertain,High] |
| HPA:005010_10 | 0.0293957472234 | 0.8 | XRCC1 PNKP APTX LIG3 | bronchus; respiratory epithelial cells[Supported,Not detected] |
| HPA:044010_10 | 0.0295887289245 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 2; epidermal cells[Supported,Not detected] |
| HPA:040010_10 | 0.0297826476016 | 0.8 | XRCC1 PNKP APTX LIG3 | seminal vesicle; glandular cells[Supported,Not detected] |
| HPA:030010_10 | 0.0299775061854 | 0.8 | XRCC1 PNKP APTX LIG3 | oral mucosa; squamous epithelial cells[Supported,Not detected] |
| HPA:056010_10 | 0.0300752888592 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; germinal center cells[Supported,Not detected] |
| HPA:004030_10 | 0.0300752888592 | 0.8 | XRCC1 PNKP APTX LIG3 | breast; myoepithelial cells[Supported,Not detected] |
| HPA:004020_10 | 0.0301733076105 | 0.8 | XRCC1 PNKP APTX LIG3 | breast; glandular cells[Supported,Not detected] |
| HPA:026010_10 | 0.0302715628066 | 0.8 | XRCC1 PNKP APTX LIG3 | liver; bile duct cells[Supported,Not detected] |
| HPA:003010_10 | 0.0302715628066 | 0.8 | XRCC1 PNKP APTX LIG3 | bone marrow; hematopoietic cells[Supported,Not detected] |
| HPA:043020_10 | 0.0303700548154 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; fibroblasts[Supported,Not detected] |
| HPA:043040_10 | 0.0303700548154 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; melanocytes[Supported,Not detected] |
| HPA:043010_10 | 0.0303700548154 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; Langerhans[Supported,Not detected] |
| HPA:043030_10 | 0.0305677507427 | 0.8 | XRCC1 PNKP APTX LIG3 | skin 1; keratinocytes[Supported,Not detected] |
| HPA:002010_10 | 0.0305677507427 | 0.8 | XRCC1 PNKP APTX LIG3 | appendix; glandular cells[Supported,Not detected] |
| HPA:037010_10 | 0.0306669553978 | 0.8 | XRCC1 PNKP APTX LIG3 | rectum; glandular cells[Supported,Not detected] |
| HPA:011020_10 | 0.0306669553978 | 0.8 | XRCC1 PNKP APTX LIG3 | colon; glandular cells[Supported,Not detected] |
| HPA:014010_10 | 0.0307663983387 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; cells in endometrial stroma[Supported,Not detected] |
| HPA:057010_10 | 0.0307663983387 | 0.8 | XRCC1 PNKP APTX LIG3 | urinary bladder; urothelial cells[Supported,Not detected] |
| HPA:019010_10 | 0.0307663983387 | 0.8 | XRCC1 PNKP APTX LIG3 | gallbladder; glandular cells[Supported,Not detected] |
| HPA:015010_10 | 0.0308660799344 | 0.8 | XRCC1 PNKP APTX LIG3 | epididymis; glandular cells[Supported,Not detected] |
| HPA:007010_10 | 0.0308660799344 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; Purkinje cells[Supported,Not detected] |
| HPA:058010_10 | 0.0308660799344 | 0.8 | XRCC1 PNKP APTX LIG3 | vagina; squamous epithelial cells[Supported,Not detected] |
| HPA:052010_10 | 0.0309660005538 | 0.8 | XRCC1 PNKP APTX LIG3 | stomach 2; glandular cells[Supported,Not detected] |
| HPA:036010_10 | 0.0309660005538 | 0.8 | XRCC1 PNKP APTX LIG3 | prostate; glandular cells[Supported,Not detected] |
| HPA:022020_10 | 0.0309660005538 | 0.8 | XRCC1 PNKP APTX LIG3 | hippocampus; neuronal cells[Supported,Not detected] |
| HPA:024010_10 | 0.0310661605666 | 0.8 | XRCC1 PNKP APTX LIG3 | kidney; cells in glomeruli[Supported,Not detected] |
| HPA:022010_10 | 0.0310661605666 | 0.8 | XRCC1 PNKP APTX LIG3 | hippocampus; glial cells[Supported,Not detected] |
| HPA:014020_10 | 0.0310661605666 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; glandular cells[Supported,Not detected] |
| HPA:006010_10 | 0.0310661605666 | 0.8 | XRCC1 PNKP APTX LIG3 | caudate; glial cells[Supported,Not detected] |
| HPA:028020_10 | 0.0310661605666 | 0.8 | XRCC1 PNKP APTX LIG3 | lymph node; non-germinal center cells[Supported,Not detected] |
| HPA:031020_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | ovary; ovarian stroma cells[Supported,Not detected] |
| HPA:056020_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | tonsil; non-germinal center cells[Supported,Not detected] |
| HPA:001040_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | adrenal gland; glandular cells[Supported,Not detected] |
| HPA:027010_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | lung; macrophages[Supported,Not detected] |
| HPA:007020_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; cells in granular layer[Supported,Not detected] |
| HPA:016010_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | esophagus; squamous epithelial cells[Supported,Not detected] |
| HPA:018010_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | fallopian tube; glandular cells[Supported,Not detected] |
| HPA:051010_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | stomach 1; glandular cells[Supported,Not detected] |
| HPA:007030_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebellum; cells in molecular layer[Supported,Not detected] |
| HPA:013020_10 | 0.0311665603422 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; glandular cells[Supported,Not detected] |
| HPA:012010_10 | 0.0312672002507 | 0.8 | XRCC1 PNKP APTX LIG3 | duodenum; glandular cells[Supported,Not detected] |
| HPA:026020_10 | 0.0312672002507 | 0.8 | XRCC1 PNKP APTX LIG3 | liver; hepatocytes[Supported,Not detected] |
| HPA:053010_10 | 0.0312672002507 | 0.8 | XRCC1 PNKP APTX LIG3 | testis; Leydig cells[Supported,Not detected] |
| HPA:046010_10 | 0.0312672002507 | 0.8 | XRCC1 PNKP APTX LIG3 | smooth muscle; smooth muscle cells[Supported,Not detected] |
| HPA:039010_10 | 0.0312672002507 | 0.8 | XRCC1 PNKP APTX LIG3 | salivary gland; glandular cells[Supported,Not detected] |
| HPA:008050_10 | 0.0312672002507 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; neuropil[Supported,Not detected] |
| HPA:008030_10 | 0.0312672002507 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; neuronal cells[Supported,Not detected] |
| HPA:008010_10 | 0.0312672002507 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; endothelial cells[Supported,Not detected] |
| HPA:032010_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | pancreas; exocrine glandular cells[Supported,Not detected] |
| HPA:055010_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | thyroid gland; glandular cells[Supported,Not detected] |
| HPA:008020_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | cerebral cortex; glial cells[Supported,Not detected] |
| HPA:045010_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | small intestine; glandular cells[Supported,Not detected] |
| HPA:050010_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | spleen; cells in red pulp[Supported,Not detected] |
| HPA:027020_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | lung; pneumocytes[Supported,Not detected] |
| HPA:035020_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; trophoblastic cells[Supported,Not detected] |
| HPA:021010_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | heart muscle; myocytes[Supported,Not detected] |
| HPA:041010_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | skeletal muscle; myocytes[Supported,Not detected] |
| HPA:024020_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | kidney; cells in tubules[Supported,Not detected] |
| HPA:013010_10 | 0.0313680806621 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 1; cells in endometrial stroma[Supported,Not detected] |
| HPA:035010_02 | 0.0370687019401 | 0.8 | XRCC1 PNKP APTX LIG3 | placenta; decidual cells[Uncertain,Medium] |
| HPA:007030_03 | 0.0384529972986 | 0.6 | XRCC1 PNKP LIG3 | cerebellum; cells in molecular layer[Uncertain,High] |
| REAC:R-HSA-6781827 | 0.0401214552357 | 0.4 | XRCC1 LIG3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| HPA:047040_11 | 0.0434826712222 | 0.6 | XRCC1 PNKP LIG3 | soft tissue 1; peripheral nerve[Supported,Low] |
| HPA:001040_13 | 0.0437586981176 | 0.6 | XRCC1 APTX PNKP | adrenal gland; glandular cells[Supported,High] |
| HPA:014010_01 | 0.0446716220879 | 0.8 | XRCC1 PNKP APTX LIG3 | endometrium 2; cells in endometrial stroma[Uncertain,Low] |
| REAC:R-HSA-5696399 | 0.0465369402216 | 0.4 | XRCC1 LIG3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| HPA:022010_12 | 0.0477444333422 | 0.6 | XRCC1 APTX PNKP | hippocampus; glial cells[Supported,Medium] |
| HPA:018010_13 | 0.0486283293616 | 0.6 | XRCC1 PNKP LIG3 | fallopian tube; glandular cells[Supported,High] |
| CORUM:213 | 0.0499494897235 | 0.2 | XRCC1 | DNA ligase IV-XRCC1 complex |
| CORUM:7352 | 0.0499494897235 | 0.2 | LIG3 | PARP1-LIG3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC1 | POLB | 1.0 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM hein (XRCC1) |
| POLB | LIG3 | 0.999 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM |
| POLB | PNKP | 0.882 | 0.818 | hein_WMM bioplex (POLB) bioplex_WMM |
| XRCC1 | LIG3 | 0.186 | 0.441 | hein_WMM bioplex_WMM youn_WMM hein (XRCC1) gupta_WMM |
| APTX | POLB | 0.078 | 0.352 | hein_WMM bioplex (POLB) bioplex_WMM |
| XRCC1 | APTX | 0.016 | 0.155 | hein_WMM bioplex_WMM hein (XRCC1) |
| XRCC1 | PNKP | 0.012 | 0.15 | hein_WMM bioplex_WMM hein (XRCC1) |
| APTX | PNKP | 0.012 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| LIG3 | PNKP | 0.008 | 0.081 | hein_WMM bioplex_WMM WMM_only |
| APTX | LIG3 | 0.008 | 0.043 | hein_WMM bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_05623 has an average edge precision of 0.408 which is ranked 3217 out of all 6965 complexes.
Related Complexes