hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05632
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUDT21 | Cleavage and polyadenylation specificity factor subunit 5 (Cleavage and polyadenylation specificity factor 25 kDa subunit) (CPSF 25 kDa subunit) (Cleavage factor Im complex 25 kDa subunit) (CFIm25) (Nucleoside diphosphate-linked moiety X motif 21) (Nudix motif 21) (Nudix hydrolase 21) (Pre-mRNA cleavage factor Im 68 kDa subunit) | UniProt NCBI |
| TXNL1 | Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein) | UniProt NCBI |
| CPSF6 | Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7) | UniProt NCBI |
| CPSF7 | Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1141 | 3.07044439662e-07 | 0.75 | NUDT21 CPSF6 CPSF7 | CF IIAm complex (Cleavage factor IIAm complex) |
| GO:1990120 | 3.63274304092e-07 | 0.75 | NUDT21 CPSF6 CPSF7 | messenger ribonucleoprotein complex assembly |
| GO:0110104 | 1.45302402969e-06 | 0.75 | NUDT21 CPSF6 CPSF7 | mRNA alternative polyadenylation |
| KEGG:03015 | 2.94026709165e-05 | 0.75 | NUDT21 CPSF6 CPSF7 | mRNA surveillance pathway |
| CORUM:1769 | 3.01612206104e-05 | 0.5 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A complex |
| CORUM:1767 | 5.02641999304e-05 | 0.5 | NUDT21 CPSF6 | CPSF6-ITCH-NUDT21-POLR2A-UBAP2L complex |
| CORUM:1768 | 7.53895486054e-05 | 0.5 | NUDT21 CPSF6 | CPSF6-EWSR1-ITCH-NUDT21-POLR2A-UBAP2L complex |
| GO:0098789 | 7.98841194917e-05 | 0.75 | NUDT21 CPSF6 CPSF7 | pre-mRNA cleavage required for polyadenylation |
| GO:0098787 | 0.000103844122491 | 0.75 | NUDT21 CPSF6 CPSF7 | mRNA cleavage involved in mRNA processing |
| GO:1900363 | 0.000203300410527 | 0.75 | NUDT21 CPSF6 CPSF7 | regulation of mRNA polyadenylation |
| GO:0005847 | 0.000203300410527 | 0.75 | NUDT21 CPSF6 CPSF7 | mRNA cleavage and polyadenylation specificity factor complex |
| GO:0006379 | 0.000296207880886 | 0.75 | NUDT21 CPSF6 CPSF7 | mRNA cleavage |
| GO:0005849 | 0.000351729129078 | 0.75 | NUDT21 CPSF6 CPSF7 | mRNA cleavage factor complex |
| GO:0031440 | 0.000943419049714 | 0.75 | NUDT21 CPSF6 CPSF7 | regulation of mRNA 3'-end processing |
| REAC:R-HSA-77595 | 0.00171688133139 | 0.5 | NUDT21 CPSF7 | Processing of Intronless Pre-mRNAs |
| GO:0006378 | 0.00358246159338 | 0.75 | NUDT21 CPSF6 CPSF7 | mRNA polyadenylation |
| REAC:R-HSA-75067 | 0.00379215175563 | 0.5 | NUDT21 CPSF7 | Processing of Capped Intronless Pre-mRNA |
| GO:0043631 | 0.00416219722544 | 0.75 | NUDT21 CPSF6 CPSF7 | RNA polyadenylation |
| GO:0051290 | 0.00514395792508 | 0.75 | NUDT21 CPSF6 CPSF7 | protein heterotetramerization |
| GO:0090501 | 0.0062689516986 | 0.75 | NUDT21 CPSF6 CPSF7 | RNA phosphodiester bond hydrolysis |
| REAC:R-HSA-72187 | 0.0143225711665 | 0.5 | NUDT21 CPSF7 | mRNA 3'-end processing |
| HPA:004030_02 | 0.0144925352807 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | breast; myoepithelial cells[Uncertain,Medium] |
| HPA:026010_01 | 0.0159314753423 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | liver; bile duct cells[Uncertain,Low] |
| HPA:006020_02 | 0.0164923137704 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | caudate; neuronal cells[Uncertain,Medium] |
| HPA:055010_13 | 0.0170761600268 | 0.75 | CPSF7 CPSF6 TXNL1 | thyroid gland; glandular cells[Supported,High] |
| GO:0051291 | 0.017346559408 | 0.75 | NUDT21 CPSF6 CPSF7 | protein heterooligomerization |
| HPA:022020_02 | 0.0179359033565 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | hippocampus; neuronal cells[Uncertain,Medium] |
| HPA:050020_01 | 0.0183584591083 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | spleen; cells in white pulp[Uncertain,Low] |
| REAC:R-HSA-73856 | 0.0195313767937 | 0.5 | NUDT21 CPSF7 | RNA Polymerase II Transcription Termination |
| HPA:022010_12 | 0.0205475883704 | 0.75 | CPSF7 CPSF6 TXNL1 | hippocampus; glial cells[Supported,Medium] |
| HPA:030010_02 | 0.0212634356468 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | oral mucosa; squamous epithelial cells[Uncertain,Medium] |
| HPA:006010_12 | 0.0254677066879 | 0.75 | CPSF7 CPSF6 TXNL1 | caudate; glial cells[Supported,Medium] |
| GO:0042382 | 0.0270421395626 | 0.5 | NUDT21 CPSF6 | paraspeckles |
| HPA:007010_02 | 0.0271284914794 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | cerebellum; Purkinje cells[Uncertain,Medium] |
| MIRNA:hsa-miR-6883-3p | 0.0271321946745 | 0.5 | NUDT21 TXNL1 | hsa-miR-6883-3p |
| HPA:028010_01 | 0.0299627277978 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | lymph node; germinal center cells[Uncertain,Low] |
| HPA:002020_01 | 0.0305135939813 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | appendix; lymphoid tissue[Uncertain,Low] |
| HPA:039010_02 | 0.0307918581839 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | salivary gland; glandular cells[Uncertain,Medium] |
| HPA:013020_02 | 0.0318523311599 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | endometrium 1; glandular cells[Uncertain,Medium] |
| HPA:027010_02 | 0.032939963177 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | lung; macrophages[Uncertain,Medium] |
| HPA:019010_13 | 0.0338599256539 | 0.75 | CPSF7 CPSF6 TXNL1 | gallbladder; glandular cells[Supported,High] |
| HPA:004020_02 | 0.0358982212617 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | breast; glandular cells[Uncertain,Medium] |
| HPA:050010_01 | 0.0374095208816 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | spleen; cells in red pulp[Uncertain,Low] |
| HPA:047020_13 | 0.0374288342448 | 0.5 | CPSF7 CPSF6 | soft tissue 1; chondrocytes[Supported,High] |
| HPA:024010_01 | 0.038968044422 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | kidney; cells in glomeruli[Uncertain,Low] |
| HPA:016010_02 | 0.0390513985277 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | esophagus; squamous epithelial cells[Uncertain,Medium] |
| HPA:040010_02 | 0.0414400996413 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | seminal vesicle; glandular cells[Uncertain,Medium] |
| HPA:032020_12 | 0.0460298167372 | 0.75 | CPSF7 CPSF6 TXNL1 | pancreas; islets of Langerhans[Supported,Medium] |
| HPA:006020_12 | 0.0462466007541 | 0.75 | CPSF7 CPSF6 TXNL1 | caudate; neuronal cells[Supported,Medium] |
| HPA:043010_12 | 0.0462466007541 | 0.75 | CPSF7 CPSF6 TXNL1 | skin 1; Langerhans[Supported,Medium] |
| HPA:009020_01 | 0.0466397694984 | 1.0 | NUDT21 TXNL1 CPSF6 CPSF7 | cervix, uterine; squamous epithelial cells[Uncertain,Low] |
| HPA:002020_12 | 0.0469009879466 | 0.75 | CPSF7 CPSF6 TXNL1 | appendix; lymphoid tissue[Supported,Medium] |
| GO:0031124 | 0.0469269676219 | 0.75 | NUDT21 CPSF6 CPSF7 | mRNA 3'-end processing |
| CORUM:351 | 0.0483178514014 | 0.5 | NUDT21 CPSF6 | Spliceosome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NUDT21 | CPSF6 | 1.0 | 0.949 | hein_WMM bioplex (CPSF6) bioplex_WMM Guru boldt youn_WMM hein (NUDT21) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| CPSF6 | CPSF7 | 0.993 | 0.918 | hein_WMM bioplex (CPSF6) bioplex_WMM youn_WMM hein (CPSF7) gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT21 | CPSF7 | 0.553 | 0.645 | hein_WMM bioplex_WMM youn_WMM hein (CPSF7,NUDT21) gupta_WMM fraction boldt_WMM treiber_WMM |
| NUDT21 | TXNL1 | 0.5 | 0.621 | bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| CPSF7 | TXNL1 | 0.0 | 0.009 | bioplex_WMM youn_WMM gupta_WMM fraction |
| CPSF6 | TXNL1 | 0.0 | 0.002 | bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_05632 has an average edge precision of 0.524 which is ranked 2375 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NUDT21 | HuMAP2_00504 HuMAP2_01021 HuMAP2_02463 HuMAP2_05632 |
| TXNL1 | HuMAP2_01971 HuMAP2_05632 |
| CPSF6 | HuMAP2_01021 HuMAP2_05632 |
| CPSF7 | HuMAP2_01021 HuMAP2_03566 HuMAP2_05632 |