hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05645

Confidence: Medium

Genename	Protein Name	Links
DPYSL3	Dihydropyrimidinase-related protein 3 (DRP-3) (Collapsin response mediator protein 4) (CRMP-4) (Unc-33-like phosphoprotein 1) (ULIP-1)	UniProt NCBI
MAPT	Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)	UniProt NCBI
CAMK2B	Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17)	UniProt NCBI
STX1B	Syntaxin-1B (Syntaxin-1B1) (Syntaxin-1B2)	UniProt NCBI
CRMP1	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Unc-33-like phosphoprotein 3) (ULIP-3)	UniProt NCBI
H2BC13	Histone H2B type 1-L (Histone H2B.c) (H2B/c)	UniProt NCBI
CAMK2A	Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)	UniProt NCBI
VSNL1	Visinin-like protein 1 (VILIP) (VLP-1) (Hippocalcin-like protein 3) (HLP3)	UniProt NCBI
PRDM1	PR domain zinc finger protein 1 (EC 2.1.1.-) (BLIMP-1) (Beta-interferon gene positive regulatory domain I-binding factor) (PR domain-containing protein 1) (Positive regulatory domain I-binding factor 1) (PRDI-BF1) (PRDI-binding factor 1)	UniProt NCBI
HMGCS1	Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)	UniProt NCBI
SNAP91	Clathrin coat assembly protein AP180 (91 kDa synaptosomal-associated protein) (Clathrin coat-associated protein AP180) (Phosphoprotein F1-20)	UniProt NCBI
GPM6B	Neuronal membrane glycoprotein M6-b (M6b)	UniProt NCBI
LIPC	Hepatic triacylglycerol lipase (HL) (Hepatic lipase) (EC 3.1.1.3) (Lipase member C)	UniProt NCBI
SYP	Synaptophysin (Major synaptic vesicle protein p38)	UniProt NCBI
GNG2	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)	UniProt NCBI
SYN1	Synapsin-1 (Brain protein 4.1) (Synapsin I)	UniProt NCBI
CNTN1	Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)	UniProt NCBI
ATP4A	Potassium-transporting ATPase alpha chain 1 (EC 7.2.2.19) (Gastric H(+)/K(+) ATPase subunit alpha) (Proton pump)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP2267	0.00162535057217	0.166666666667	SYP STX1B SYN1	Synaptic Vesicle Pathway
KEGG:04971	0.00284587178326	0.166666666667	ATP4A CAMK2B CAMK2A	Gastric acid secretion
GO:0050804	0.00296028755886	0.333333333333	SYN1 CAMK2B MAPT STX1B CAMK2A SYP	modulation of chemical synaptic transmission
GO:0099177	0.00305574986624	0.333333333333	SYN1 CAMK2B MAPT STX1B CAMK2A SYP	regulation of trans-synaptic signaling
REAC:R-HSA-936837	0.00664202816546	0.166666666667	ATP4A CAMK2B CAMK2A	Ion transport by P-type ATPases
KEGG:04713	0.00850195300415	0.166666666667	GNG2 CAMK2B CAMK2A	Circadian entrainment
KEGG:04725	0.0110030878012	0.166666666667	GNG2 CAMK2B CAMK2A	Cholinergic synapse
REAC:R-HSA-111932	0.0141183622596	0.111111111111	CAMK2A CAMK2B	CaMK IV-mediated phosphorylation of CREB
KEGG:04728	0.0217619403209	0.166666666667	GNG2 CAMK2B CAMK2A	Dopaminergic synapse
WP:WP536	0.0284341475251	0.166666666667	GNG2 CAMK2B CAMK2A	Calcium Regulation in the Cardiac Cell
WP:WP289	0.0367640045526	0.166666666667	GNG2 CAMK2B CAMK2A	Myometrial Relaxation and Contraction Pathways
REAC:R-HSA-112315	0.0388399731282	0.222222222222	GNG2 CAMK2A CAMK2B SYN1	Transmission across Chemical Synapses
REAC:R-HSA-111885	0.0407029591871	0.166666666667	GNG2 CAMK2B CAMK2A	Opioid Signalling
WP:WP2380	0.041016094066	0.166666666667	SYN1 MAPT CAMK2A	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
GO:0051588	0.0453358122653	0.222222222222	SYN1 CAMK2A STX1B GPM6B	regulation of neurotransmitter transport
REAC:R-HSA-399956	0.0468258473561	0.111111111111	CRMP1 DPYSL3	CRMPs in Sema3A signaling
CORUM:6436	0.0499396839595	0.0555555555556	ATP4A	ATP4A-ATP4B complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
DPYSL3	CRMP1	0.922	0.843	bioplex (DPYSL3) bioplex_WMM youn_WMM gupta_WMM fraction
DPYSL3	HMGCS1	0.066	0.347	fraction
CNTN1	DPYSL3	0.049	0.296	bioplex_WMM fraction
CRMP1	GNG2	0.03	0.239	bioplex_WMM WMM_only
ATP4A	LIPC	0.03	0.234	bioplex (LIPC) bioplex_WMM
ATP4A	GNG2	0.028	0.231	bioplex_WMM WMM_only
GNG2	VSNL1	0.027	0.229	bioplex_WMM WMM_only
VSNL1	GPM6B	0.027	0.224	bioplex_WMM WMM_only
SYN1	STX1B	0.025	0.215	bioplex_WMM WMM_only
CAMK2A	MAPT	0.024	0.214	bioplex_WMM WMM_only
CRMP1	VSNL1	0.023	0.212	bioplex_WMM WMM_only
GNG2	GPM6B	0.023	0.208	bioplex_WMM WMM_only
ATP4A	CRMP1	0.023	0.208	bioplex_WMM gupta_WMM WMM_only
DPYSL3	GNG2	0.023	0.209	bioplex_WMM WMM_only
GNG2	MAPT	0.022	0.21	bioplex_WMM WMM_only
CRMP1	MAPT	0.022	0.208	bioplex_WMM youn_WMM gupta_WMM WMM_only
VSNL1	SNAP91	0.022	0.208	bioplex_WMM WMM_only
VSNL1	STX1B	0.022	0.208	bioplex_WMM WMM_only
SYN1	VSNL1	0.022	0.208	bioplex_WMM WMM_only
H2BC13	SYN1	0.022	0.208	bioplex_WMM WMM_only
H2BC13	STX1B	0.022	0.208	bioplex_WMM WMM_only
CAMK2B	CAMK2A	0.022	0.207	bioplex_WMM boldt (CAMK2A) boldt_WMM
CAMK2A	GNG2	0.022	0.207	bioplex_WMM WMM_only
ATP4A	VSNL1	0.022	0.205	bioplex_WMM WMM_only
SYN1	MAPT	0.022	0.204	bioplex_WMM WMM_only
STX1B	MAPT	0.022	0.204	bioplex_WMM WMM_only
CAMK2A	SYN1	0.022	0.202	bioplex_WMM WMM_only
CAMK2A	STX1B	0.022	0.202	bioplex_WMM WMM_only
VSNL1	MAPT	0.022	0.198	bioplex_WMM WMM_only
CAMK2A	VSNL1	0.022	0.199	bioplex_WMM WMM_only
SYP	SNAP91	0.021	0.191	bioplex_WMM WMM_only
DPYSL3	MAPT	0.021	0.187	bioplex_WMM youn_WMM gupta_WMM WMM_only
GNG2	SYN1	0.021	0.186	bioplex_WMM WMM_only
GNG2	SNAP91	0.021	0.186	bioplex_WMM WMM_only
GNG2	STX1B	0.021	0.186	bioplex_WMM WMM_only
CRMP1	GPM6B	0.02	0.186	bioplex_WMM WMM_only
SNAP91	GPM6B	0.02	0.186	bioplex_WMM WMM_only
SYN1	GPM6B	0.02	0.186	bioplex_WMM WMM_only
STX1B	GPM6B	0.02	0.186	bioplex_WMM WMM_only
DPYSL3	PRDM1	0.02	0.184	bioplex (PRDM1) bioplex_WMM
H2BC13	VSNL1	0.02	0.188	bioplex_WMM WMM_only
CRMP1	CAMK2A	0.02	0.187	bioplex_WMM WMM_only
MAPT	GPM6B	0.02	0.189	bioplex_WMM WMM_only
CAMK2A	GPM6B	0.02	0.19	bioplex_WMM WMM_only
DPYSL3	CAMK2A	0.02	0.187	bioplex_WMM WMM_only
H2BC13	MAPT	0.019	0.184	bioplex_WMM WMM_only
H2BC13	CAMK2A	0.019	0.183	bioplex_WMM WMM_only
ATP4A	MAPT	0.019	0.181	bioplex_WMM gupta_WMM WMM_only
ATP4A	GPM6B	0.019	0.181	bioplex_WMM WMM_only
CRMP1	SNAP91	0.019	0.182	bioplex_WMM youn_WMM WMM_only
SYP	VSNL1	0.019	0.186	bioplex_WMM WMM_only
CRMP1	STX1B	0.019	0.185	bioplex_WMM WMM_only
CRMP1	SYN1	0.019	0.185	bioplex_WMM WMM_only
ATP4A	CAMK2A	0.018	0.18	bioplex_WMM WMM_only
H2BC13	GNG2	0.018	0.178	bioplex_WMM WMM_only
ATP4A	DPYSL3	0.018	0.175	bioplex_WMM gupta_WMM WMM_only
H2BC13	GPM6B	0.018	0.176	bioplex_WMM WMM_only
DPYSL3	STX1B	0.018	0.176	bioplex_WMM WMM_only
DPYSL3	SYN1	0.018	0.176	bioplex_WMM WMM_only
DPYSL3	VSNL1	0.018	0.177	bioplex_WMM WMM_only
ATP4A	STX1B	0.018	0.176	bioplex_WMM WMM_only
ATP4A	SNAP91	0.018	0.176	bioplex_WMM WMM_only
ATP4A	SYN1	0.018	0.176	bioplex_WMM WMM_only
SYP	GNG2	0.017	0.174	bioplex_WMM WMM_only
SYP	GPM6B	0.017	0.175	bioplex_WMM WMM_only
MAPT	SNAP91	0.017	0.164	bioplex_WMM WMM_only
CAMK2A	SNAP91	0.016	0.161	bioplex_WMM WMM_only
H2BC13	CRMP1	0.016	0.161	bioplex_WMM WMM_only
STX1B	SNAP91	0.016	0.165	bioplex_WMM WMM_only
SYN1	SNAP91	0.016	0.165	bioplex_WMM WMM_only
DPYSL3	GPM6B	0.016	0.157	bioplex_WMM WMM_only
H2BC13	DPYSL3	0.016	0.157	bioplex_WMM WMM_only
ATP4A	H2BC13	0.016	0.155	bioplex_WMM WMM_only
CRMP1	SYP	0.015	0.152	bioplex_WMM WMM_only
CNTN1	STX1B	0.015	0.148	bioplex_WMM WMM_only
CNTN1	SYN1	0.015	0.148	bioplex_WMM WMM_only
H2BC13	SNAP91	0.015	0.149	bioplex_WMM WMM_only
SYP	MAPT	0.015	0.139	bioplex_WMM WMM_only
ATP4A	SYP	0.015	0.139	bioplex_WMM WMM_only
CAMK2A	SYP	0.015	0.14	bioplex_WMM WMM_only
SYP	SYN1	0.015	0.14	bioplex_WMM WMM_only
SYP	STX1B	0.015	0.14	bioplex_WMM WMM_only
DPYSL3	SNAP91	0.014	0.138	bioplex_WMM youn_WMM gupta_WMM WMM_only
CAMK2B	MAPT	0.014	0.143	bioplex_WMM gupta_WMM WMM_only
H2BC13	CNTN1	0.013	0.143	bioplex_WMM WMM_only
CNTN1	VSNL1	0.013	0.143	bioplex_WMM WMM_only
H2BC13	SYP	0.013	0.143	bioplex_WMM WMM_only
CNTN1	MAPT	0.013	0.149	bioplex_WMM WMM_only
CNTN1	CAMK2A	0.013	0.15	bioplex_WMM WMM_only
CAMK2B	SNAP91	0.013	0.155	bioplex_WMM WMM_only
CAMK2B	STX1B	0.013	0.155	bioplex_WMM WMM_only
CAMK2B	SYN1	0.013	0.155	bioplex_WMM WMM_only
DPYSL3	SYP	0.013	0.153	bioplex_WMM WMM_only
CAMK2B	VSNL1	0.013	0.152	bioplex_WMM WMM_only
CAMK2B	GNG2	0.013	0.149	bioplex_WMM WMM_only
CNTN1	GNG2	0.012	0.15	bioplex_WMM WMM_only
CNTN1	GPM6B	0.012	0.145	bioplex_WMM WMM_only
DPYSL3	CAMK2B	0.012	0.145	bioplex_WMM youn_WMM gupta_WMM WMM_only
CAMK2B	GPM6B	0.012	0.147	bioplex_WMM WMM_only
H2BC13	CAMK2B	0.012	0.147	bioplex_WMM WMM_only
CRMP1	CAMK2B	0.012	0.147	bioplex_WMM gupta_WMM WMM_only
CAMK2B	SYP	0.012	0.153	bioplex_WMM WMM_only
CNTN1	SNAP91	0.011	0.152	bioplex_WMM WMM_only
CNTN1	CRMP1	0.011	0.144	bioplex_WMM WMM_only
ATP4A	CAMK2B	0.011	0.147	bioplex_WMM WMM_only
ATP4A	CNTN1	0.011	0.141	bioplex_WMM WMM_only
CNTN1	SYP	0.01	0.131	bioplex_WMM WMM_only
CNTN1	CAMK2B	0.009	0.091	bioplex_WMM WMM_only

Images

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Complex HuMAP2_05645 has an average edge precision of 0.185 which is ranked 6384 out of all 6965 complexes.

Related Complexes

Genename	Complexes
DPYSL3	HuMAP2_00292 HuMAP2_02427 HuMAP2_05645 HuMAP2_06701
MAPT	HuMAP2_05645
CAMK2B	HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05645
STX1B	HuMAP2_05645
CRMP1	HuMAP2_00292 HuMAP2_05645 HuMAP2_06701
H2BC13	HuMAP2_00219 HuMAP2_01712 HuMAP2_02888 HuMAP2_05240 HuMAP2_05645 HuMAP2_06067 HuMAP2_06674
CAMK2A	HuMAP2_00728 HuMAP2_02476 HuMAP2_05494 HuMAP2_05645
VSNL1	HuMAP2_05645
PRDM1	HuMAP2_05645
HMGCS1	HuMAP2_00292 HuMAP2_01959 HuMAP2_04726 HuMAP2_05645
SNAP91	HuMAP2_05645
GPM6B	HuMAP2_05645
LIPC	HuMAP2_04379 HuMAP2_05645
SYP	HuMAP2_05645 HuMAP2_05923
GNG2	HuMAP2_05645
SYN1	HuMAP2_05645
CNTN1	HuMAP2_00292 HuMAP2_05645
ATP4A	HuMAP2_00147 HuMAP2_03190 HuMAP2_04379 HuMAP2_05645

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05645