hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05657
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PPP1R12A | Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) | UniProt NCBI |
| DBN1 | Drebrin (Developmentally-regulated brain protein) | UniProt NCBI |
| MISP | Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein) | UniProt NCBI |
| MYO6 | Unconventional myosin-VI (Unconventional myosin-6) | UniProt NCBI |
| GSN | Gelsolin (AGEL) (Actin-depolymerizing factor) (ADF) (Brevin) | UniProt NCBI |
| ACTB | Actin, cytoplasmic 1 (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0015629 | 1.48146606194e-05 | 1.0 | MYO6 GSN PPP1R12A ACTB MISP DBN1 | actin cytoskeleton |
| WP:WP51 | 0.000551527499474 | 0.5 | ACTB GSN PPP1R12A | Regulation of Actin Cytoskeleton |
| GO:0005884 | 0.00125526288107 | 0.666666666667 | MYO6 ACTB DBN1 MISP | actin filament |
| REAC:R-HSA-190873 | 0.00146070989197 | 0.333333333333 | MYO6 ACTB | Gap junction degradation |
| KEGG:04810 | 0.00175401113695 | 0.5 | ACTB GSN PPP1R12A | Regulation of actin cytoskeleton |
| REAC:R-HSA-190828 | 0.012367185342 | 0.333333333333 | MYO6 ACTB | Gap junction trafficking |
| GO:0044430 | 0.0127921370156 | 1.0 | MYO6 GSN PPP1R12A ACTB MISP DBN1 | cytoskeletal part |
| REAC:R-HSA-157858 | 0.0131143608537 | 0.333333333333 | MYO6 ACTB | Gap junction trafficking and regulation |
| GO:0099512 | 0.0149781295365 | 0.833333333333 | MYO6 ACTB DBN1 PPP1R12A MISP | supramolecular fiber |
| GO:0099081 | 0.0158586891275 | 0.833333333333 | MYO6 ACTB DBN1 PPP1R12A MISP | supramolecular polymer |
| GO:0099080 | 0.0160093787736 | 0.833333333333 | MYO6 ACTB DBN1 PPP1R12A MISP | supramolecular complex |
| HP:0100540 | 0.0189383441407 | 0.333333333333 | ACTB GSN | Palpebral edema |
| GO:0005938 | 0.0222594167129 | 0.666666666667 | MYO6 GSN DBN1 MISP | cell cortex |
| KEGG:04611 | 0.0374860246019 | 0.333333333333 | ACTB PPP1R12A | Platelet activation |
| WP:WP4217 | 0.0377845147795 | 0.333333333333 | ACTB GSN | Ebola Virus Pathway on Host |
| GO:0005856 | 0.0465478032663 | 1.0 | MYO6 GSN PPP1R12A ACTB MISP DBN1 | cytoskeleton |
| CORUM:756 | 0.0499726005494 | 0.166666666667 | GSN | Prune-Gelsolin complex |
| CORUM:817 | 0.0499726005494 | 0.166666666667 | PPP1R12A | MRIP-MBS complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DBN1 | ACTB | 0.667 | 0.701 | hein_WMM bioplex (DBN1) bioplex_WMM hein (ACTB) gupta_WMM |
| DBN1 | GSN | 0.641 | 0.688 | hein_WMM bioplex (DBN1) bioplex_WMM hein (DBN1) boldt_WMM treiber_WMM |
| DBN1 | MYO6 | 0.264 | 0.481 | hein_WMM bioplex (DBN1,MYO6) bioplex_WMM youn_WMM hein (DBN1) gupta_WMM treiber_WMM |
| ACTB | GSN | 0.104 | 0.37 | hein_WMM bioplex_WMM boldt hein (ACTB) boldt_WMM |
| PPP1R12A | DBN1 | 0.093 | 0.355 | hein_WMM youn_WMM hein (DBN1) gupta_WMM |
| PPP1R12A | ACTB | 0.09 | 0.355 | hein_WMM boldt hein (ACTB) gupta_WMM boldt_WMM |
| MISP | DBN1 | 0.057 | 0.321 | hein_WMM hein (DBN1) treiber_WMM |
| MISP | ACTB | 0.053 | 0.301 | hein_WMM bioplex (MISP) hein (ACTB) |
| MYO6 | ACTB | 0.042 | 0.269 | hein_WMM bioplex (MYO6) bioplex_WMM boldt hein (ACTB) gupta_WMM boldt_WMM |
| MYO6 | GSN | 0.013 | 0.148 | hein_WMM bioplex (MYO6) bioplex_WMM treiber_WMM |
| PPP1R12A | MYO6 | 0.005 | 0.008 | hein_WMM youn_WMM gupta_WMM WMM_only |
| MISP | MYO6 | 0.005 | 0.007 | hein_WMM bioplex (MISP) treiber_WMM |
| PPP1R12A | MISP | 0.004 | 0.009 | hein_WMM WMM_only |
| PPP1R12A | GSN | 0.004 | 0.011 | hein_WMM WMM_only |
| MISP | GSN | 0.003 | 0.011 | hein_WMM WMM_only treiber_WMM |
Images
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Complex HuMAP2_05657 has an average edge precision of 0.269 which is ranked 5042 out of all 6965 complexes.
Related Complexes