hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05660
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IL18 | Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma) | UniProt NCBI |
| TLL1 | Tolloid-like protein 1 (EC 3.4.24.-) | UniProt NCBI |
| TLL2 | Tolloid-like protein 2 (EC 3.4.24.-) | UniProt NCBI |
| RMND5B | E3 ubiquitin-protein transferase RMND5B (EC 2.3.2.27) (Protein RMD5 homolog B) | UniProt NCBI |
| TDGF1 | Teratocarcinoma-derived growth factor 1 (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) | UniProt NCBI |
| BMP1 | Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2214320 | 2.70475878656e-06 | 0.5 | BMP1 TLL1 TLL2 | Anchoring fibril formation |
| REAC:R-HSA-2243919 | 4.84853251826e-06 | 0.5 | BMP1 TLL1 TLL2 | Crosslinking of collagen fibrils |
| REAC:R-HSA-2022090 | 0.000163763058745 | 0.5 | BMP1 TLL1 TLL2 | Assembly of collagen fibrils and other multimeric structures |
| REAC:R-HSA-1650814 | 0.000223228442122 | 0.5 | BMP1 TLL1 TLL2 | Collagen biosynthesis and modifying enzymes |
| REAC:R-HSA-1474290 | 0.000560531240275 | 0.5 | BMP1 TLL1 TLL2 | Collagen formation |
| REAC:R-HSA-1474228 | 0.00199485952479 | 0.5 | BMP1 TLL1 TLL2 | Degradation of the extracellular matrix |
| REAC:R-HSA-1474244 | 0.0179459751507 | 0.5 | BMP1 TLL1 TLL2 | Extracellular matrix organization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BMP1 | TLL2 | 0.984 | 0.899 | bioplex (BMP1) bioplex_WMM |
| BMP1 | TLL1 | 0.976 | 0.892 | bioplex (BMP1) bioplex_WMM |
| BMP1 | RMND5B | 0.123 | 0.394 | bioplex (BMP1) bioplex_WMM |
| TDGF1 | RMND5B | 0.029 | 0.231 | bioplex (TDGF1) bioplex_WMM |
| TDGF1 | IL18 | 0.023 | 0.209 | bioplex (TDGF1) bioplex_WMM |
| TLL1 | TLL2 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| TLL1 | RMND5B | 0.008 | 0.082 | bioplex_WMM WMM_only |
| TLL2 | RMND5B | 0.008 | 0.082 | bioplex_WMM WMM_only |
| RMND5B | IL18 | 0.008 | 0.013 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05660 has an average edge precision of 0.322 which is ranked 4321 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IL18 | HuMAP2_05660 |
| TLL1 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |
| TLL2 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |
| RMND5B | HuMAP2_03249 HuMAP2_05660 HuMAP2_06026 |
| TDGF1 | HuMAP2_01503 HuMAP2_05660 HuMAP2_06026 |
| BMP1 | HuMAP2_02103 HuMAP2_03249 HuMAP2_05660 |