hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05662

Confidence: Medium

Genename	Protein Name	Links
RIOX1	Ribosomal oxygenase 1 (60S ribosomal protein L8 histidine hydroxylase) (Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66) (EC 1.14.11.-) (EC 1.14.11.27) (Histone lysine demethylase NO66) (Myc-associated protein with JmjC domain) (Nucleolar protein 66) (hsNO66) (Ribosomal oxygenase NO66) (ROX)	UniProt NCBI
DIMT1	Probable dimethyladenosine transferase (EC 2.1.1.183) (DIM1 dimethyladenosine transferase 1 homolog) (DIM1 dimethyladenosine transferase 1-like) (Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase) (Probable 18S rRNA dimethylase) (Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase)	UniProt NCBI
BLM	Bloom syndrome protein (EC 3.6.4.12) (DNA helicase, RecQ-like type 2) (RecQ2) (RecQ protein-like 3)	UniProt NCBI
MRM3	rRNA methyltransferase 3, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1370)-2'-O)-methyltransferase) (16S rRNA [Gm1370] 2'-O-methyltransferase) (RNA methyltransferase-like protein 1)	UniProt NCBI
SPATS2L	SPATS2-like protein (DNA polymerase-transactivated protein 6) (Stress granule and nucleolar protein) (SGNP)	UniProt NCBI
TFB1M	Dimethyladenosine transferase 1, mitochondrial (EC 2.1.1.-) (Mitochondrial 12S rRNA dimethylase 1) (Mitochondrial transcription factor B1) (h-mtTFB) (h-mtTFB1) (hTFB1M) (mtTFB1) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1)	UniProt NCBI
SPOUT1	Putative methyltransferase C9orf114 (EC 2.1.1.-) (Centromere protein 32) (CENP-32) (Kinetochore-associated protein) (SPOUT domain-containing methyltransferase 1)	UniProt NCBI
GNL3L	Guanine nucleotide-binding protein-like 3-like protein	UniProt NCBI
SRP72	Signal recognition particle subunit SRP72 (SRP72) (Signal recognition particle 72 kDa protein)	UniProt NCBI
ZNF131	Zinc finger protein 131	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-6793080	0.00127142302931	0.2	TFB1M MRM3	rRNA modification in the mitochondrion
REAC:R-HSA-8868766	0.00380880777617	0.2	TFB1M MRM3	rRNA processing in the mitochondrion
HPA:004010_22	0.00971195520636	0.5	ZNF131 DIMT1 TFB1M SRP72 BLM	breast; adipocytes[Approved,Medium]
GO:0008649	0.0105009568253	0.3	DIMT1 TFB1M MRM3	rRNA methyltransferase activity
GO:0140102	0.0105009568253	0.3	DIMT1 TFB1M MRM3	catalytic activity, acting on a rRNA
GO:0031167	0.0123497091753	0.3	DIMT1 TFB1M MRM3	rRNA methylation
GO:0000154	0.0438273782088	0.3	DIMT1 TFB1M MRM3	rRNA modification
GO:0003676	0.0486319481008	0.9	SRP72 TFB1M ZNF131 SPATS2L MRM3 SPOUT1 DIMT1 GNL3L BLM	nucleic acid binding

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SRP72	GNL3L	0.221	0.466	hein_WMM bioplex_WMM Guru youn_WMM hein (SRP72) fraction treiber_WMM
SRP72	MRM3	0.057	0.32	hein_WMM bioplex_WMM youn_WMM hein (SRP72)
SRP72	SPOUT1	0.056	0.315	hein_WMM bioplex_WMM youn_WMM hein (SRP72) treiber_WMM
SRP72	DIMT1	0.047	0.293	hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction
SRP72	SPATS2L	0.04	0.268	hein_WMM youn_WMM hein (SRP72) gupta_WMM boldt_WMM treiber_WMM
MRM3	ZNF131	0.034	0.265	bioplex (MRM3) bioplex_WMM
SRP72	RIOX1	0.032	0.24	hein_WMM hein (SRP72) treiber_WMM
SRP72	TFB1M	0.031	0.236	hein_WMM bioplex_WMM hein (SRP72)
SRP72	BLM	0.02	0.186	hein_WMM bioplex_WMM youn_WMM hein (SRP72) gupta_WMM
SPOUT1	BLM	0.01	0.097	hein_WMM bioplex_WMM youn_WMM WMM_only
TFB1M	BLM	0.008	0.06	hein_WMM bioplex_WMM WMM_only
BLM	SPATS2L	0.008	0.058	hein_WMM youn_WMM gupta_WMM WMM_only
DIMT1	SPATS2L	0.008	0.052	hein_WMM youn_WMM WMM_only treiber_WMM
SPOUT1	TFB1M	0.008	0.049	hein_WMM bioplex_WMM WMM_only treiber_WMM
ZNF131	BLM	0.007	0.01	youn_WMM gupta_WMM WMM_only
MRM3	TFB1M	0.007	0.009	hein_WMM WMM_only
RIOX1	SPATS2L	0.007	0.008	hein_WMM WMM_only treiber_WMM
GNL3L	BLM	0.007	0.012	hein_WMM bioplex_WMM youn_WMM WMM_only
RIOX1	DIMT1	0.007	0.01	hein_WMM WMM_only
RIOX1	MRM3	0.007	0.01	hein_WMM WMM_only
MRM3	BLM	0.007	0.01	hein_WMM bioplex_WMM WMM_only
MRM3	DIMT1	0.007	0.01	hein_WMM bioplex_WMM WMM_only
RIOX1	SPOUT1	0.007	0.005	hein_WMM WMM_only treiber_WMM
DIMT1	BLM	0.007	0.004	hein_WMM youn_WMM WMM_only
SPOUT1	GNL3L	0.007	0.005	hein_WMM youn_WMM WMM_only
GNL3L	SPATS2L	0.007	0.008	hein_WMM youn_WMM WMM_only treiber_WMM
SPOUT1	SPATS2L	0.007	0.007	hein_WMM youn_WMM WMM_only treiber_WMM
GNL3L	TFB1M	0.007	0.007	hein_WMM WMM_only
MRM3	GNL3L	0.007	0.006	hein_WMM bioplex_WMM WMM_only
MRM3	SPATS2L	0.007	0.006	hein_WMM WMM_only
TFB1M	SPATS2L	0.007	0.003	hein_WMM WMM_only treiber_WMM
ZNF131	GNL3L	0.007	0.004	youn_WMM WMM_only
RIOX1	GNL3L	0.007	0.001	hein_WMM WMM_only treiber_WMM
RIOX1	TFB1M	0.007	0.001	hein_WMM WMM_only treiber_WMM
SRP72	ZNF131	0.007	0.001	youn_WMM WMM_only
ZNF131	DIMT1	0.007	0.002	youn_WMM WMM_only
MRM3	SPOUT1	0.007	0.002	hein_WMM bioplex_WMM WMM_only
ZNF131	SPATS2L	0.007	0.001	youn_WMM WMM_only
RIOX1	BLM	0.007	0.001	hein_WMM WMM_only
DIMT1	TFB1M	0.007	0.005	hein_WMM bioplex_WMM WMM_only treiber_WMM
SPOUT1	DIMT1	0.005	0.008	bioplex_WMM youn_WMM WMM_only treiber_WMM
GNL3L	DIMT1	0.005	0.011	hein_WMM bioplex_WMM youn_WMM WMM_only

Images

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Complex HuMAP2_05662 has an average edge precision of 0.073 which is ranked 6969 out of all 6965 complexes.

Related Complexes

Genename	Complexes
RIOX1	HuMAP2_00610 HuMAP2_01734 HuMAP2_04712 HuMAP2_05662
DIMT1	HuMAP2_01447 HuMAP2_01734 HuMAP2_05662 HuMAP2_06905
BLM	HuMAP2_05662
MRM3	HuMAP2_00671 HuMAP2_01447 HuMAP2_03065 HuMAP2_05662 HuMAP2_06887
SPATS2L	HuMAP2_05662
TFB1M	HuMAP2_05662
SPOUT1	HuMAP2_01447 HuMAP2_05662
GNL3L	HuMAP2_01447 HuMAP2_02420 HuMAP2_04574 HuMAP2_04828 HuMAP2_05662
SRP72	HuMAP2_00227 HuMAP2_00235 HuMAP2_01447 HuMAP2_01983 HuMAP2_04330 HuMAP2_05662 HuMAP2_06281 HuMAP2_06502 HuMAP2_06905 HuMAP2_06948
ZNF131	HuMAP2_00671 HuMAP2_01588 HuMAP2_02144 HuMAP2_02489 HuMAP2_03065 HuMAP2_04144 HuMAP2_05662 HuMAP2_06887

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05662