hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05669
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CSNK2B | Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) | UniProt NCBI |
| CSNK2A1 | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | UniProt NCBI |
| NKAPD1 | Uncharacterized protein NKAPD1 (NKAP domain containing protein 1) | UniProt NCBI |
| CSNK2A2 | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2720 | 6.75231048499e-10 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:5224 | 6.75231048499e-10 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:2719 | 2.70078815927e-09 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Casein kinase II-HMG1 complex |
| CORUM:938 | 6.75163031135e-09 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | FACT complex, UV-activated |
| REAC:R-HSA-201688 | 7.56068325699e-08 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | WNT mediated activation of DVL |
| REAC:R-HSA-8934903 | 1.13404535396e-07 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Receptor Mediated Mitophagy |
| REAC:R-HSA-2514853 | 2.22736463084e-07 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Condensation of Prometaphase Chromosomes |
| REAC:R-HSA-445144 | 1.53820861406e-06 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Signal transduction by L1 |
| REAC:R-HSA-5205647 | 2.73044427427e-06 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Mitophagy |
| REAC:R-HSA-1483191 | 3.50713401381e-06 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Synthesis of PC |
| CORUM:5225 | 5.02777038712e-06 | 0.5 | CSNK2B CSNK2A1 | Casein kinase II (beta-dimer, alpha-dimer) |
| CORUM:5223 | 5.02777038712e-06 | 0.5 | CSNK2B CSNK2A2 | Casein kinase II (beta-dimer, alpha'-dimer) |
| REAC:R-HSA-8939243 | 9.62627312117e-06 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| KEGG:04137 | 1.0146820263e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Mitophagy - animal |
| REAC:R-HSA-6814122 | 1.23194951195e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| KEGG:04520 | 1.40519436497e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Adherens junction |
| WP:WP4336 | 1.71006587841e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:03008 | 1.96107212107e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Ribosome biogenesis in eukaryotes |
| KEGG:04064 | 2.11980782425e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | NF-kappa B signaling pathway |
| KEGG:05235 | 2.20228638729e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP4258 | 2.38151267007e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| WP:WP428 | 4.4550815102e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Wnt Signaling |
| REAC:R-HSA-8948751 | 6.7458189168e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Regulation of PTEN stability and activity |
| KEGG:05162 | 9.12832394729e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Measles |
| WP:WP4262 | 9.81492425143e-05 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Breast cancer pathway |
| KEGG:04310 | 0.000138556392266 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Wnt signaling pathway |
| REAC:R-HSA-1632852 | 0.000142536631926 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Macroautophagy |
| REAC:R-HSA-390466 | 0.000157957097998 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Chaperonin-mediated protein folding |
| REAC:R-HSA-6804756 | 0.000163333735977 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-391251 | 0.000192050220564 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Protein folding |
| REAC:R-HSA-9612973 | 0.000237627678426 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Autophagy |
| REAC:R-HSA-1483206 | 0.00026664242496 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Glycerophospholipid biosynthesis |
| REAC:R-HSA-373760 | 0.000297923324705 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | L1CAM interactions |
| REAC:R-HSA-6807070 | 0.000537928298347 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | PTEN Regulation |
| REAC:R-HSA-5633007 | 0.000847823442334 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Regulation of TP53 Activity |
| REAC:R-HSA-1483257 | 0.00136676597405 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Phospholipid metabolism |
| GO:0006656 | 0.00147288799354 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | phosphatidylcholine biosynthetic process |
| REAC:R-HSA-68877 | 0.00152914291965 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Mitotic Prometaphase |
| REAC:R-HSA-8878171 | 0.00230643324807 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-201681 | 0.00240260362929 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | TCF dependent signaling in response to WNT |
| REAC:R-HSA-1257604 | 0.00250140055192 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 0.00399488218563 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Intracellular signaling by second messengers |
| GO:0031519 | 0.00550256096709 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | PcG protein complex |
| REAC:R-HSA-195721 | 0.00653784113487 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Signaling by WNT |
| GO:0005956 | 0.00811409485621 | 0.5 | CSNK2B CSNK2A1 | protein kinase CK2 complex |
| REAC:R-HSA-3700989 | 0.00924066477779 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Transcriptional Regulation by TP53 |
| GO:0046470 | 0.00950554068334 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | phosphatidylcholine metabolic process |
| REAC:R-HSA-68886 | 0.0117390466083 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | M Phase |
| REAC:R-HSA-8953897 | 0.0253615474256 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Cellular responses to external stimuli |
| REAC:R-HSA-422475 | 0.0294332368862 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Axon guidance |
| REAC:R-HSA-69278 | 0.0299490115235 | 0.75 | CSNK2B CSNK2A1 CSNK2A2 | Cell Cycle, Mitotic |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSNK2A2 | CSNK2A1 | 1.0 | 0.949 | hein_WMM bioplex (CSNK2A2) bioplex_WMM boldt youn_WMM hein (CSNK2A2) Malo gupta_WMM fraction boldt_WMM |
| CSNK2A1 | CSNK2B | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CSNK2A2 | CSNK2B | 0.994 | 0.923 | hein_WMM bioplex_WMM boldt youn_WMM hein (CSNK2A2) gupta_WMM boldt_WMM |
| CSNK2A2 | NKAPD1 | 0.775 | 0.752 | bioplex (CSNK2A2,NKAPD1) bioplex_WMM |
| NKAPD1 | CSNK2A1 | 0.557 | 0.648 | bioplex (NKAPD1) bioplex_WMM |
| NKAPD1 | CSNK2B | 0.142 | 0.406 | bioplex (NKAPD1) bioplex_WMM |
Images
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Complex HuMAP2_05669 has an average edge precision of 0.771 which is ranked 1050 out of all 6965 complexes.
Related Complexes