hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05672
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| LAGE3 | EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2) | UniProt NCBI |
| NFYB | Nuclear transcription factor Y subunit beta (CAAT box DNA-binding protein subunit B) (Nuclear transcription factor Y subunit B) (NF-YB) | UniProt NCBI |
| NFYA | Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) | UniProt NCBI |
| NFYC | Nuclear transcription factor Y subunit gamma (CAAT box DNA-binding protein subunit C) (Nuclear transcription factor Y subunit C) (NF-YC) (Transactivator HSM-1/2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4478 | 6.75231048499e-10 | 0.75 | NFYB NFYA NFYC | CBF-DNA complex |
| CORUM:4498 | 2.70078815927e-09 | 0.75 | NFYB NFYA NFYC | p32-CBF-DNA complex |
| REAC:R-HSA-381183 | 1.13404535396e-07 | 0.75 | NFYB NFYA NFYC | ATF6 (ATF6-alpha) activates chaperone genes |
| REAC:R-HSA-381033 | 2.22736463084e-07 | 0.75 | NFYB NFYA NFYC | ATF6 (ATF6-alpha) activates chaperones |
| REAC:R-HSA-9614657 | 6.14088879325e-07 | 0.75 | NFYB NFYA NFYC | FOXO-mediated transcription of cell death genes |
| GO:0016602 | 1.45302402969e-06 | 0.75 | NFYB NFYA NFYC | CCAAT-binding factor complex |
| REAC:R-HSA-380994 | 2.73044427427e-06 | 0.75 | NFYB NFYA NFYC | ATF4 activates genes in response to endoplasmic reticulum stress |
| REAC:R-HSA-381042 | 4.92812658075e-06 | 0.75 | NFYB NFYA NFYC | PERK regulates gene expression |
| KEGG:04612 | 6.65741516792e-06 | 0.75 | NFYB NFYA NFYC | Antigen processing and presentation |
| REAC:R-HSA-2426168 | 1.13724154433e-05 | 0.75 | NFYB NFYA NFYC | Activation of gene expression by SREBF (SREBP) |
| REAC:R-HSA-1655829 | 2.64063995051e-05 | 0.75 | NFYB NFYA NFYC | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| REAC:R-HSA-9614085 | 4.15544275563e-05 | 0.75 | NFYB NFYA NFYC | FOXO-mediated transcription |
| REAC:R-HSA-381119 | 0.000123581847658 | 0.75 | NFYB NFYA NFYC | Unfolded Protein Response (UPR) |
| KEGG:05152 | 0.000147252104815 | 0.75 | NFYB NFYA NFYC | Tuberculosis |
| REAC:R-HSA-1989781 | 0.00025917959103 | 0.75 | NFYB NFYA NFYC | PPARA activates gene expression |
| REAC:R-HSA-400206 | 0.00026664242496 | 0.75 | NFYB NFYA NFYC | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| REAC:R-HSA-8957322 | 0.000436852235365 | 0.75 | NFYB NFYA NFYC | Metabolism of steroids |
| GO:0106118 | 0.00331394418715 | 0.75 | NFYB NFYA NFYC | regulation of sterol biosynthetic process |
| GO:0045540 | 0.00331394418715 | 0.75 | NFYB NFYA NFYC | regulation of cholesterol biosynthetic process |
| GO:0090181 | 0.0062689516986 | 0.75 | NFYB NFYA NFYC | regulation of cholesterol metabolic process |
| GO:0006695 | 0.0100430829723 | 0.75 | NFYB NFYA NFYC | cholesterol biosynthetic process |
| GO:1902930 | 0.0100430829723 | 0.75 | NFYB NFYA NFYC | regulation of alcohol biosynthetic process |
| GO:1902653 | 0.0111781410126 | 0.75 | NFYB NFYA NFYC | secondary alcohol biosynthetic process |
| GO:0016126 | 0.011776375189 | 0.75 | NFYB NFYA NFYC | sterol biosynthetic process |
| GO:0050810 | 0.0150889595431 | 0.75 | NFYB NFYA NFYC | regulation of steroid biosynthetic process |
| GO:0000980 | 0.017346559408 | 0.75 | NFYB NFYA NFYC | RNA polymerase II distal enhancer sequence-specific DNA binding |
| GO:0001158 | 0.0264744736345 | 0.75 | NFYB NFYA NFYC | enhancer sequence-specific DNA binding |
| GO:0019218 | 0.0320435644688 | 0.75 | NFYB NFYA NFYC | regulation of steroid metabolic process |
| GO:0035326 | 0.0383423539882 | 0.75 | NFYB NFYA NFYC | enhancer binding |
| GO:0008203 | 0.0469269676219 | 0.75 | NFYB NFYA NFYC | cholesterol metabolic process |
| CORUM:6091 | 0.0499140284799 | 0.25 | NFYA | NF-YA-LaminA complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NFYB | NFYC | 1.0 | 0.949 | hein_WMM bioplex (NFYC) bioplex_WMM Guru hein (NFYB,NFYC) Malo fraction |
| NFYA | NFYC | 0.602 | 0.67 | hein_WMM bioplex (NFYA,NFYC) bioplex_WMM Guru hein (NFYA,NFYC) fraction |
| NFYA | NFYB | 0.228 | 0.468 | hein_WMM bioplex_WMM Guru hein (NFYA,NFYB) fraction |
| NFYB | LAGE3 | 0.043 | 0.269 | fraction |
Images
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Complex HuMAP2_05672 has an average edge precision of 0.589 which is ranked 1994 out of all 6965 complexes.
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