hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05679
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1 (Eukaryotic translation initiation factor 2 subunit alpha) (eIF-2-alpha) (eIF-2A) (eIF-2alpha) | UniProt NCBI |
| EIF2S3 | Eukaryotic translation initiation factor 2 subunit 3 (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72731 | 4.69258569465e-05 | 1.0 | EIF2S3 EIF2S1 | Recycling of eIF2:GDP |
| CORUM:5183 | 4.69258569465e-05 | 1.0 | EIF2S3 EIF2S1 | DNA-PK-Ku-eIF2-NF90-NF45 complex |
| WP:WP107 | 0.000456412131355 | 1.0 | EIF2S3 EIF2S1 | Translation Factors |
| REAC:R-HSA-381042 | 0.000680424925724 | 1.0 | EIF2S3 EIF2S1 | PERK regulates gene expression |
| KEGG:03013 | 0.00169649664321 | 1.0 | EIF2S3 EIF2S1 | RNA transport |
| REAC:R-HSA-72695 | 0.00222227451111 | 1.0 | EIF2S3 EIF2S1 | Formation of the ternary complex, and subsequently, the 43S complex |
| MIRNA:hsa-miR-4777-3p | 0.00256915028412 | 1.0 | EIF2S3 EIF2S1 | hsa-miR-4777-3p |
| GO:0005850 | 0.00270494046827 | 1.0 | EIF2S3 EIF2S1 | eukaryotic translation initiation factor 2 complex |
| REAC:R-HSA-72702 | 0.00286750504412 | 1.0 | EIF2S3 EIF2S1 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.00286750504412 | 1.0 | EIF2S3 EIF2S1 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0029663845284 | 1.0 | EIF2S3 EIF2S1 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| REAC:R-HSA-381119 | 0.00570316754246 | 1.0 | EIF2S3 EIF2S1 | Unfolded Protein Response (UPR) |
| REAC:R-HSA-382556 | 0.00812990471598 | 1.0 | EIF2S3 EIF2S1 | ABC-family proteins mediated transport |
| REAC:R-HSA-156827 | 0.0100471611569 | 1.0 | EIF2S3 EIF2S1 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.0102315127378 | 1.0 | EIF2S3 EIF2S1 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-72613 | 0.0115688996608 | 1.0 | EIF2S3 EIF2S1 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.0115688996608 | 1.0 | EIF2S3 EIF2S1 | Cap-dependent Translation Initiation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EIF2S1 | EIF2S3 | 0.981 | 0.896 | hein_WMM bioplex_WMM Malo gupta_WMM fraction treiber_WMM |
Images
Click to enlarge
Complex HuMAP2_05679 has an average edge precision of 0.896 which is ranked 586 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EIF2S1 | HuMAP2_00042 HuMAP2_02097 HuMAP2_03090 HuMAP2_05064 HuMAP2_05679 |
| EIF2S3 | HuMAP2_00042 HuMAP2_00747 HuMAP2_01153 HuMAP2_02097 HuMAP2_03090 HuMAP2_03390 HuMAP2_05064 HuMAP2_05679 |