hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05696

Confidence: Medium

Genename	Protein Name	Links
RDH11	Retinol dehydrogenase 11 (EC 1.1.1.300) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12) (Prostate short-chain dehydrogenase/reductase 1) (Retinal reductase 1) (RalR1) (Short chain dehydrogenase/reductase family 7C member 1)	UniProt NCBI
SIGMAR1	Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1)	UniProt NCBI
NAT8L	N-acetylaspartate synthetase (NAA synthetase) (EC 2.3.1.17) (Camello-like protein 3) (N-acetyltransferase 8-like protein)	UniProt NCBI
TMEM248	Transmembrane protein 248	UniProt NCBI
TSPAN5	Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)	UniProt NCBI
TMEM186	Transmembrane protein 186	UniProt NCBI
RDH12	Retinol dehydrogenase 12 (EC 1.1.1.300) (All-trans and 9-cis retinol dehydrogenase) (Short chain dehydrogenase/reductase family 7C member 2)	UniProt NCBI
IMMP1L	Mitochondrial inner membrane protease subunit 1 (EC 3.4.21.-) (IMP1-like protein)	UniProt NCBI
ZDHHC21	Palmitoyltransferase ZDHHC21 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 21) (DHHC-21)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-2453902	0.00875250290708	0.222222222222	RDH11 RDH12	The canonical retinoid cycle in rods (twilight vision)
KEGG:00830	0.0225278542333	0.222222222222	RDH11 RDH12	Retinol metabolism
CORUM:6735	0.0499262710315	0.111111111111	SIGMAR1	SIGMAR1-KCNH2 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
NAT8L	TSPAN5	0.834	0.78	bioplex (TSPAN5) bioplex_WMM
TSPAN5	IMMP1L	0.334	0.526	bioplex (TSPAN5) bioplex_WMM
TSPAN5	RDH11	0.262	0.482	bioplex (TSPAN5) bioplex_WMM
TSPAN5	TMEM248	0.164	0.42	bioplex (TSPAN5) bioplex_WMM
TSPAN5	TMEM186	0.111	0.381	bioplex (TSPAN5) bioplex_WMM
TSPAN5	ZDHHC21	0.045	0.293	bioplex (TSPAN5) bioplex_WMM
TSPAN5	SIGMAR1	0.023	0.206	bioplex (TSPAN5) bioplex_WMM
TSPAN5	RDH12	0.022	0.198	bioplex (TSPAN5) bioplex_WMM
NAT8L	TMEM248	0.009	0.108	bioplex_WMM WMM_only
IMMP1L	TMEM248	0.009	0.108	bioplex_WMM WMM_only
RDH12	TMEM248	0.009	0.102	bioplex_WMM WMM_only
TMEM248	ZDHHC21	0.009	0.099	bioplex_WMM WMM_only
NAT8L	IMMP1L	0.009	0.098	bioplex_WMM WMM_only
NAT8L	RDH12	0.008	0.096	bioplex_WMM WMM_only
IMMP1L	RDH12	0.008	0.09	bioplex_WMM WMM_only
NAT8L	ZDHHC21	0.008	0.086	bioplex_WMM WMM_only
IMMP1L	ZDHHC21	0.008	0.067	bioplex_WMM WMM_only
TMEM186	TMEM248	0.008	0.063	bioplex_WMM WMM_only
RDH12	ZDHHC21	0.008	0.06	bioplex_WMM WMM_only
NAT8L	TMEM186	0.008	0.016	bioplex_WMM WMM_only
SIGMAR1	TMEM248	0.008	0.01	bioplex_WMM WMM_only
TMEM248	RDH11	0.007	0.009	bioplex_WMM WMM_only
TMEM186	IMMP1L	0.007	0.007	bioplex_WMM WMM_only
TMEM186	ZDHHC21	0.007	0.009	bioplex_WMM WMM_only
TMEM186	RDH12	0.007	0.005	bioplex_WMM WMM_only
NAT8L	SIGMAR1	0.007	0.004	bioplex_WMM WMM_only
NAT8L	RDH11	0.007	0.002	bioplex_WMM WMM_only
IMMP1L	SIGMAR1	0.007	0.002	bioplex_WMM WMM_only
IMMP1L	RDH11	0.007	0.001	bioplex_WMM WMM_only
SIGMAR1	RDH12	0.007	0.004	bioplex_WMM WMM_only
SIGMAR1	ZDHHC21	0.007	0.001	bioplex_WMM WMM_only
RDH12	RDH11	0.007	0.002	bioplex_WMM WMM_only
ZDHHC21	RDH11	0.007	0.003	bioplex_WMM WMM_only
TMEM186	RDH11	0.006	0.004	bioplex_WMM WMM_only
TMEM186	SIGMAR1	0.006	0.007	bioplex_WMM WMM_only
SIGMAR1	RDH11	0.004	0.015	bioplex_WMM gupta_WMM WMM_only

Images

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Complex HuMAP2_05696 has an average edge precision of 0.121 which is ranked 6866 out of all 6965 complexes.

Related Complexes

Genename	Complexes
RDH11	HuMAP2_05696
SIGMAR1	HuMAP2_02958 HuMAP2_05696 HuMAP2_06709
NAT8L	HuMAP2_02270 HuMAP2_05696
TMEM248	HuMAP2_05696
TSPAN5	HuMAP2_02270 HuMAP2_05696
TMEM186	HuMAP2_02507 HuMAP2_05415 HuMAP2_05696 HuMAP2_06330
RDH12	HuMAP2_03515 HuMAP2_05696
IMMP1L	HuMAP2_02603 HuMAP2_04552 HuMAP2_05696 HuMAP2_05742
ZDHHC21	HuMAP2_05696

hu.MAP 2.0: Complex View

Search for a protein

Complex: HuMAP2_05696