hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05697
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RHOA | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12) | UniProt NCBI |
| RHOC | Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9) | UniProt NCBI |
| DAAM2 | Disheveled-associated activator of morphogenesis 2 | UniProt NCBI |
| DAAM1 | Disheveled-associated activator of morphogenesis 1 | UniProt NCBI |
| RTKN2 | Rhotekin-2 (Pleckstrin homology domain-containing family K member 1) (PH domain-containing family K member 1) | UniProt NCBI |
| RHOD | Rho-related GTP-binding protein RhoD (Rho-related protein HP1) (RhoHP1) | UniProt NCBI |
| C1orf198 | Uncharacterized protein C1orf198 | UniProt NCBI |
| ARHGEF1 | Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-194840 | 6.90355722144e-05 | 0.5 | RHOA RHOD ARHGEF1 RHOC | Rho GTPase cycle |
| REAC:R-HSA-5663220 | 7.33687312406e-05 | 0.5 | DAAM1 RHOC RHOD RHOA | RHO GTPases Activate Formins |
| REAC:R-HSA-194315 | 0.000181135963543 | 0.625 | DAAM1 RHOC RHOD ARHGEF1 RHOA | Signaling by Rho GTPases |
| GO:0030950 | 0.000837474301274 | 0.375 | RHOA RHOD RHOC | establishment or maintenance of actin cytoskeleton polarity |
| WP:WP428 | 0.000995258902323 | 0.375 | DAAM1 DAAM2 RHOA | Wnt Signaling |
| REAC:R-HSA-416482 | 0.00110207094363 | 0.375 | RHOA ARHGEF1 RHOC | G alpha (12/13) signalling events |
| REAC:R-HSA-5666185 | 0.00160842632192 | 0.25 | RHOA RHOC | RHO GTPases Activate Rhotekin and Rhophilins |
| REAC:R-HSA-195258 | 0.00211175058683 | 0.5 | DAAM1 RHOC RHOD RHOA | RHO GTPase Effectors |
| GO:0030952 | 0.0023070725905 | 0.375 | RHOA RHOD RHOC | establishment or maintenance of cytoskeleton polarity |
| KEGG:04310 | 0.00244581534875 | 0.375 | DAAM1 DAAM2 RHOA | Wnt signaling pathway |
| REAC:R-HSA-5627117 | 0.00761952471968 | 0.25 | RHOA RHOC | RHO GTPases Activate ROCKs |
| REAC:R-HSA-5625900 | 0.00761952471968 | 0.25 | RHOA RHOC | RHO GTPases activate CIT |
| REAC:R-HSA-416572 | 0.00761952471968 | 0.25 | RHOA RHOC | Sema4D induced cell migration and growth-cone collapse |
| GO:0007266 | 0.00861930713405 | 0.5 | RHOA RHOD ARHGEF1 RHOC | Rho protein signal transduction |
| WP:WP524 | 0.0088953208221 | 0.25 | RHOA ARHGEF1 | G13 Signaling Pathway |
| REAC:R-HSA-400685 | 0.0112612209329 | 0.25 | RHOA RHOC | Sema4D in semaphorin signaling |
| GO:1902766 | 0.0126230555186 | 0.25 | RHOA RHOC | skeletal muscle satellite cell migration |
| WP:WP3680 | 0.0245464965472 | 0.25 | DAAM1 RHOA | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| WP:WP35 | 0.0467166389275 | 0.25 | RHOA ARHGEF1 | G Protein Signaling Pathways |
| WP:WP2431 | 0.0488756896787 | 0.25 | RHOA RHOC | Spinal Cord Injury |
| CORUM:553 | 0.0497224828424 | 0.125 | RHOA | RHOA-IP3R-TRPC1 complex |
| CORUM:816 | 0.0497224828424 | 0.125 | RHOA | MRIP-RHOA complex |
| CORUM:3177 | 0.0497224828424 | 0.125 | ARHGEF1 | GNA14-p115RhoGEF complex |
| CORUM:6722 | 0.0497224828424 | 0.125 | RHOD | FILIP1-RhoD complex |
| CORUM:6724 | 0.0497224828424 | 0.125 | RHOD | WHAMM-RhoD complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RHOA | RHOC | 0.92 | 0.844 | bioplex (RHOC) bioplex_WMM |
| DAAM1 | RHOC | 0.085 | 0.349 | bioplex (RHOC) bioplex_WMM |
| DAAM1 | RHOD | 0.05 | 0.295 | bioplex (RHOD) bioplex_WMM |
| DAAM2 | RHOC | 0.05 | 0.295 | bioplex (RHOC) bioplex_WMM |
| ARHGEF1 | RHOA | 0.045 | 0.284 | bioplex (RHOA) bioplex_WMM |
| RTKN2 | RHOC | 0.028 | 0.232 | bioplex (RHOC) bioplex_WMM |
| ARHGEF1 | RHOC | 0.027 | 0.232 | bioplex (RHOC) bioplex_WMM |
| C1orf198 | RHOC | 0.025 | 0.215 | bioplex (RHOC) bioplex_WMM |
| RHOD | C1orf198 | 0.01 | 0.129 | bioplex (RHOD) bioplex_WMM |
| DAAM1 | C1orf198 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| RTKN2 | DAAM2 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| RTKN2 | RHOA | 0.008 | 0.066 | bioplex_WMM WMM_only |
| DAAM2 | RHOA | 0.008 | 0.066 | bioplex_WMM WMM_only |
| ARHGEF1 | DAAM2 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| RTKN2 | ARHGEF1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| RTKN2 | C1orf198 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| C1orf198 | DAAM2 | 0.008 | 0.04 | bioplex_WMM WMM_only |
| C1orf198 | RHOA | 0.008 | 0.024 | bioplex_WMM gupta_WMM WMM_only |
| ARHGEF1 | C1orf198 | 0.007 | 0.009 | bioplex_WMM gupta_WMM WMM_only |
| DAAM1 | ARHGEF1 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| DAAM1 | DAAM2 | 0.007 | 0.012 | bioplex_WMM WMM_only |
| RTKN2 | DAAM1 | 0.007 | 0.012 | bioplex_WMM WMM_only |
| DAAM1 | RHOA | 0.005 | 0.011 | bioplex (RHOA) bioplex_WMM |
Images
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Complex HuMAP2_05697 has an average edge precision of 0.149 which is ranked 6707 out of all 6965 complexes.
Related Complexes