hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05698
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KDM1A | Lysine-specific histone demethylase 1A (EC 1.-.-.-) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) | UniProt NCBI |
| HMG20B | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (SMARCE1-related protein) (BRCA2-associated factor 35) (HMG box-containing protein 20B) (HMG domain-containing protein 2) (HMG domain-containing protein HMGX2) (Sox-like transcriptional factor) (Structural DNA-binding protein BRAF35) | UniProt NCBI |
| PHF21A | PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80) | UniProt NCBI |
| ZMYM2 | Zinc finger MYM-type protein 2 (Fused in myeloproliferative disorders protein) (Rearranged in atypical myeloproliferative disorder protein) (Zinc finger protein 198) | UniProt NCBI |
| RCOR1 | REST corepressor 1 (Protein CoREST) | UniProt NCBI |
| HMG20A | High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein 1) (HMG domain-containing protein HMGX1) | UniProt NCBI |
| GSE1 | Genetic suppressor element 1 | UniProt NCBI |
| RCOR3 | REST corepressor 3 | UniProt NCBI |
| RCOR2 | REST corepressor 2 | UniProt NCBI |
| BMP10 | Bone morphogenetic protein 10 (BMP-10) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:626 | 4.75119880294e-19 | 0.7 | RCOR3 RCOR1 PHF21A ZMYM2 HMG20B HMG20A KDM1A | LSD1 complex |
| CORUM:1492 | 2.16441743941e-16 | 0.6 | RCOR1 PHF21A ZMYM2 HMG20B GSE1 KDM1A | BHC110 complex |
| CORUM:633 | 4.76062154934e-16 | 0.6 | RCOR1 PHF21A ZMYM2 HMG20B GSE1 KDM1A | anti-BHC110 complex |
| CORUM:632 | 1.27350773356e-14 | 0.6 | RCOR1 PHF21A ZMYM2 HMG20B GSE1 KDM1A | Anti-HDAC2 complex |
| CORUM:636 | 1.14280476802e-10 | 0.4 | HMG20B PHF21A RCOR1 KDM1A | BHC complex |
| CORUM:620 | 2.66568478766e-10 | 0.4 | HMG20B PHF21A RCOR1 KDM1A | CoREST-HDAC complex |
| CORUM:871 | 2.66568478766e-10 | 0.4 | HMG20B PHF21A RCOR1 KDM1A | BRAF53-BRCA2 complex |
| CORUM:642 | 1.0973651278e-05 | 0.3 | RCOR3 RCOR1 KDM1A | CtBP complex |
| CORUM:624 | 3.01890677263e-05 | 0.2 | RCOR1 KDM1A | LSD1-CoREST complex |
| REAC:R-HSA-3214815 | 6.08121287388e-05 | 0.4 | HMG20B PHF21A RCOR1 KDM1A | HDACs deacetylate histones |
| CORUM:648 | 9.0534767973e-05 | 0.2 | RCOR1 KDM1A | HDAC1-associated core complex cI |
| REAC:R-HSA-983231 | 0.000522666381847 | 0.4 | HMG20B PHF21A RCOR1 KDM1A | Factors involved in megakaryocyte development and platelet production |
| CORUM:643 | 0.00108408476104 | 0.2 | RCOR1 KDM1A | CtBP core complex |
| CORUM:646 | 0.00108408476104 | 0.2 | RCOR1 KDM1A | HDAC1-associated protein complex |
| REAC:R-HSA-4839726 | 0.0041964850839 | 0.4 | HMG20B PHF21A RCOR1 KDM1A | Chromatin organization |
| REAC:R-HSA-3247509 | 0.0041964850839 | 0.4 | HMG20B PHF21A RCOR1 KDM1A | Chromatin modifying enzymes |
| TF:M01175_1 | 0.0126256896008 | 0.9 | RCOR3 RCOR1 PHF21A ZMYM2 HMG20A HMG20B RCOR2 GSE1 KDM1A | Factor: CKROX; motif: SCCCTCCCC; match class: 1 |
| CORUM:0000000 | 0.0163530596685 | 0.8 | RCOR3 RCOR1 PHF21A ZMYM2 HMG20A HMG20B GSE1 KDM1A | CORUM root |
| HPA:013010_13 | 0.0388874035001 | 0.3 | HMG20A RCOR1 KDM1A | endometrium 1; cells in endometrial stroma[Supported,High] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KDM1A | RCOR1 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| PHF21A | HMG20B | 1.0 | 0.949 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| HMG20A | HMG20B | 1.0 | 0.949 | hein_WMM bioplex (HMG20A,HMG20B) bioplex_WMM hein (HMG20A) |
| HMG20A | PHF21A | 0.999 | 0.949 | hein_WMM bioplex (HMG20A) bioplex_WMM boldt hein (HMG20A) boldt_WMM |
| HMG20A | GSE1 | 0.998 | 0.938 | hein_WMM bioplex (HMG20A) bioplex_WMM youn_WMM hein (HMG20A) |
| KDM1A | RCOR3 | 0.997 | 0.93 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| RCOR1 | HMG20A | 0.996 | 0.926 | hein_WMM bioplex (HMG20A) bioplex_WMM boldt youn_WMM hein (HMG20A) boldt_WMM |
| KDM1A | HMG20A | 0.984 | 0.899 | hein_WMM bioplex (HMG20A) bioplex_WMM boldt youn_WMM hein (HMG20A) boldt_WMM |
| GSE1 | HMG20B | 0.98 | 0.896 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| HMG20A | RCOR3 | 0.924 | 0.843 | hein_WMM bioplex (HMG20A) bioplex_WMM youn_WMM hein (HMG20A) |
| HMG20A | BMP10 | 0.778 | 0.752 | bioplex (HMG20A) bioplex_WMM |
| RCOR1 | HMG20B | 0.607 | 0.673 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| KDM1A | HMG20B | 0.417 | 0.573 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| RCOR3 | HMG20B | 0.4 | 0.56 | hein_WMM bioplex (HMG20B) bioplex_WMM |
| KDM1A | ZMYM2 | 0.101 | 0.363 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| RCOR1 | RCOR3 | 0.089 | 0.356 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| HMG20B | RCOR2 | 0.081 | 0.35 | bioplex (HMG20B) bioplex_WMM |
| HMG20A | RCOR2 | 0.062 | 0.345 | bioplex (HMG20A) bioplex_WMM |
| RCOR1 | GSE1 | 0.039 | 0.263 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KDM1A | GSE1 | 0.026 | 0.22 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| RCOR3 | GSE1 | 0.019 | 0.187 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RCOR1 | RCOR2 | 0.015 | 0.138 | bioplex_WMM WMM_only |
| KDM1A | RCOR2 | 0.014 | 0.139 | bioplex_WMM WMM_only |
| RCOR3 | RCOR2 | 0.014 | 0.138 | bioplex_WMM WMM_only |
| RCOR1 | PHF21A | 0.012 | 0.144 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RCOR3 | PHF21A | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| PHF21A | RCOR2 | 0.011 | 0.143 | bioplex_WMM WMM_only |
| GSE1 | PHF21A | 0.011 | 0.144 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| RCOR3 | ZMYM2 | 0.011 | 0.138 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| KDM1A | PHF21A | 0.011 | 0.145 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| RCOR1 | ZMYM2 | 0.01 | 0.142 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| GSE1 | RCOR2 | 0.01 | 0.101 | bioplex_WMM WMM_only |
| BMP10 | HMG20B | 0.008 | 0.088 | bioplex_WMM WMM_only |
| BMP10 | PHF21A | 0.008 | 0.085 | bioplex_WMM WMM_only |
| BMP10 | RCOR2 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| BMP10 | GSE1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| ZMYM2 | GSE1 | 0.008 | 0.033 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ZMYM2 | RCOR2 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| RCOR1 | BMP10 | 0.008 | 0.023 | bioplex_WMM WMM_only |
| ZMYM2 | HMG20B | 0.008 | 0.023 | hein_WMM bioplex_WMM WMM_only |
| RCOR3 | BMP10 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| KDM1A | BMP10 | 0.008 | 0.025 | bioplex_WMM WMM_only |
| HMG20A | ZMYM2 | 0.007 | 0.004 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ZMYM2 | PHF21A | 0.007 | 0.002 | hein_WMM bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_05698 has an average edge precision of 0.36 which is ranked 3760 out of all 6965 complexes.
Related Complexes