hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05703
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GPN1 | GPN-loop GTPase 1 (EC 3.6.5.-) (MBD2-interacting protein) (MBDin) (RNAPII-associated protein 4) (XPA-binding protein 1) | UniProt NCBI |
| GPN3 | GPN-loop GTPase 3 (ATP-binding domain 1 family member C) | UniProt NCBI |
| RPRD1B | Regulation of nuclear pre-mRNA domain-containing protein 1B (Cell cycle-related and expression-elevated protein in tumor) | UniProt NCBI |
| POLR2G | DNA-directed RNA polymerase II subunit RPB7 (RNA polymerase II subunit B7) (DNA-directed RNA polymerase II subunit G) (RNA polymerase II 19 kDa subunit) (RPB19) | UniProt NCBI |
| POLR2F | DNA-directed RNA polymerases I, II, and III subunit RPABC2 (RNA polymerases I, II, and III subunit ABC2) (DNA-directed RNA polymerase II subunit F) (DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide) (RPABC14.4) (RPB14.4) (RPB6 homolog) (RPC15) | UniProt NCBI |
| RPAP2 | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 (EC 3.1.3.16) (RNA polymerase II-associated protein 2) | UniProt NCBI |
| POLR2D | DNA-directed RNA polymerase II subunit RPB4 (RNA polymerase II subunit B4) (DNA-directed RNA polymerase II subunit D) (RNA polymerase II 16 kDa subunit) (RPB16) | UniProt NCBI |
| POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8) | UniProt NCBI |
| POLR2E | DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (DNA-directed RNA polymerase II 23 kDa polypeptide) (DNA-directed RNA polymerase II subunit E) (RPB5 homolog) (XAP4) | UniProt NCBI |
| POLR2I | DNA-directed RNA polymerase II subunit RPB9 (RNA polymerase II subunit B9) (DNA-directed RNA polymerase II subunit I) (RNA polymerase II 14.5 kDa subunit) (RPB14.5) | UniProt NCBI |
| POLR2L | DNA-directed RNA polymerases I, II, and III subunit RPABC5 (RNA polymerases I, II, and III subunit ABC5) (DNA-directed RNA polymerase III subunit L) (RNA polymerase II 7.6 kDa subunit) (RPB7.6) (RPB10 homolog) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:104 | 5.48299141443e-19 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase II core complex |
| CORUM:2686 | 1.1877020952e-18 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | BRCA1-core RNA polymerase II complex |
| REAC:R-HSA-6807505 | 1.33396797076e-17 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase II transcribes snRNA genes |
| CORUM:2685 | 1.3447964286e-17 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase II (RNAPII) |
| REAC:R-HSA-8851708 | 1.12879209679e-16 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Signaling by FGFR2 IIIa TM |
| CORUM:103 | 2.38931210412e-16 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase II holoenzyme complex |
| CORUM:2825 | 4.53895315322e-16 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | BRCA1-RNA polymerase II complex |
| REAC:R-HSA-167242 | 5.48684083803e-16 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Abortive elongation of HIV-1 transcript in the absence of Tat |
| REAC:R-HSA-203927 | 7.74430546028e-16 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | MicroRNA (miRNA) biogenesis |
| GO:0005665 | 8.77711848353e-16 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase II, core complex |
| KEGG:03020 | 9.34349731911e-16 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase |
| REAC:R-HSA-1839126 | 1.07534486187e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | FGFR2 mutant receptor activation |
| REAC:R-HSA-6803529 | 1.47117823694e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | FGFR2 alternative splicing |
| GO:0042795 | 1.7904873916e-15 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | snRNA transcription by RNA polymerase II |
| REAC:R-HSA-77075 | 1.98562318402e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Pol II CTD phosphorylation and interaction with CE |
| REAC:R-HSA-167160 | 1.98562318402e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection |
| GO:0009301 | 2.05014799457e-15 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | snRNA transcription |
| GO:0016591 | 2.34274188883e-15 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase II, holoenzyme |
| REAC:R-HSA-5601884 | 3.48824050607e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | PIWI-interacting RNA (piRNA) biogenesis |
| REAC:R-HSA-72086 | 3.48824050607e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | mRNA Capping |
| REAC:R-HSA-167243 | 7.51715519807e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Tat-mediated HIV elongation arrest and recovery |
| REAC:R-HSA-167238 | 7.51715519807e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Pausing and recovery of Tat-mediated HIV elongation |
| REAC:R-HSA-113418 | 9.53875839865e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Formation of the Early Elongation Complex |
| REAC:R-HSA-167158 | 9.53875839865e-15 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Formation of the HIV-1 Early Elongation Complex |
| REAC:R-HSA-167287 | 1.20089416992e-14 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | HIV elongation arrest and recovery |
| REAC:R-HSA-5655253 | 1.20089416992e-14 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Signaling by FGFR2 in disease |
| REAC:R-HSA-167290 | 1.20089416992e-14 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Pausing and recovery of HIV elongation |
| GO:0055029 | 3.55835587445e-14 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 3.92180184192e-14 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | DNA-directed RNA polymerase complex |
| REAC:R-HSA-168325 | 4.15593351945e-14 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Viral Messenger RNA Synthesis |
| GO:0030880 | 5.21812647031e-14 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase complex |
| GO:0098781 | 5.72789882816e-14 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | ncRNA transcription |
| REAC:R-HSA-167200 | 8.53419236933e-14 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Formation of HIV-1 elongation complex containing HIV-1 Tat |
| REAC:R-HSA-167246 | 8.53419236933e-14 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Tat-mediated elongation of the HIV-1 transcript |
| REAC:R-HSA-167169 | 8.53419236933e-14 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | HIV Transcription Elongation |
| REAC:R-HSA-167152 | 1.19146120838e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Formation of HIV elongation complex in the absence of HIV Tat |
| REAC:R-HSA-167162 | 1.3996370614e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-73779 | 1.3996370614e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| REAC:R-HSA-167161 | 1.3996370614e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | HIV Transcription Initiation |
| REAC:R-HSA-75953 | 1.3996370614e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-76042 | 1.3996370614e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-73776 | 1.3996370614e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-72165 | 2.97384066822e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | mRNA Splicing - Minor Pathway |
| REAC:R-HSA-1226099 | 3.42557404798e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Signaling by FGFR in disease |
| REAC:R-HSA-6781823 | 3.42557404798e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Formation of TC-NER Pre-Incision Complex |
| REAC:R-HSA-5654738 | 6.67411016874e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Signaling by FGFR2 |
| REAC:R-HSA-112382 | 7.57076264026e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Formation of RNA Pol II elongation complex |
| REAC:R-HSA-75955 | 7.57076264026e-13 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Polymerase II Transcription Elongation |
| REAC:R-HSA-6796648 | 1.09061841165e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | TP53 Regulates Transcription of DNA Repair Genes |
| REAC:R-HSA-6782210 | 1.37697354446e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 1.54279604191e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Dual incision in TC-NER |
| GO:0006370 | 1.71391138516e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | 7-methylguanosine mRNA capping |
| GO:0009452 | 1.71391138516e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | 7-methylguanosine RNA capping |
| REAC:R-HSA-190236 | 1.92627854809e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Signaling by FGFR |
| GO:0036260 | 2.17483691489e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA capping |
| REAC:R-HSA-167172 | 2.9429409986e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Transcription of the HIV genome |
| GO:0003899 | 5.23633879576e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | DNA-directed 5'-3' RNA polymerase activity |
| REAC:R-HSA-6781827 | 5.83666572683e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-674695 | 8.3911657712e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Polymerase II Pre-transcription Events |
| GO:0035019 | 9.47552842435e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | somatic stem cell population maintenance |
| GO:0034062 | 9.47552842435e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | 5'-3' RNA polymerase activity |
| GO:0097747 | 9.47552842435e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA polymerase activity |
| GO:0050434 | 9.47552842435e-12 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | positive regulation of viral transcription |
| REAC:R-HSA-5578749 | 4.0567774037e-11 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Transcriptional regulation by small RNAs |
| REAC:R-HSA-5696398 | 6.97732824433e-11 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Nucleotide Excision Repair |
| GO:0061695 | 8.62370782114e-11 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-5619507 | 9.59536840464e-11 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 9.59536840464e-11 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| GO:0046782 | 1.72613388198e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of viral transcription |
| REAC:R-HSA-168273 | 2.30530111733e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-211000 | 2.57060610784e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Gene Silencing by RNA |
| REAC:R-HSA-162599 | 2.71277512872e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168255 | 3.52905647832e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Influenza Life Cycle |
| KEGG:05016 | 4.07825294779e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Huntington disease |
| REAC:R-HSA-9018519 | 4.11321638879e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Estrogen-dependent gene expression |
| REAC:R-HSA-162587 | 5.27093500143e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | HIV Life Cycle |
| WP:WP4022 | 5.61708373492e-10 | 0.545454545455 | POLR2E POLR2D POLR2L POLR2G POLR2I POLR2H | Pyrimidine metabolism |
| REAC:R-HSA-168254 | 5.80649053864e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Influenza Infection |
| GO:0006283 | 8.21692822701e-10 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | transcription-coupled nucleotide-excision repair |
| GO:0008543 | 1.33075978572e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | fibroblast growth factor receptor signaling pathway |
| GO:0098727 | 1.4597945547e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | maintenance of cell number |
| GO:0006368 | 1.4597945547e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | transcription elongation from RNA polymerase II promoter |
| GO:0019827 | 1.4597945547e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | stem cell population maintenance |
| REAC:R-HSA-72163 | 2.15082135089e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 2.93553742923e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | mRNA Splicing |
| WP:WP405 | 3.79175709788e-09 | 0.454545454545 | POLR2G POLR2E POLR2I POLR2F POLR2H | Eukaryotic Transcription Initiation |
| GO:0044344 | 4.06454894519e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | cellular response to fibroblast growth factor stimulus |
| GO:0071774 | 4.75510983728e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | response to fibroblast growth factor |
| REAC:R-HSA-8939211 | 5.63736143128e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | ESR-mediated signaling |
| GO:0048524 | 5.97837929261e-09 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | positive regulation of viral process |
| REAC:R-HSA-162906 | 1.05614679529e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | HIV Infection |
| GO:0006289 | 1.13919702242e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | nucleotide-excision repair |
| GO:0006354 | 1.13919702242e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | DNA-templated transcription, elongation |
| GO:0060964 | 1.13919702242e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of gene silencing by miRNA |
| GO:0060966 | 1.30451153705e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of gene silencing by RNA |
| GO:0060147 | 1.30451153705e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of posttranscriptional gene silencing |
| REAC:R-HSA-72203 | 1.52740181748e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0016779 | 1.69750449315e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | nucleotidyltransferase activity |
| REAC:R-HSA-9006931 | 1.98945378561e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Signaling by Nuclear Receptors |
| GO:0035195 | 8.47093704634e-08 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | gene silencing by miRNA |
| GO:0060968 | 1.03672203106e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of gene silencing |
| REAC:R-HSA-73780 | 1.07479001855e-07 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase III Chain Elongation |
| GO:0035194 | 1.32387984281e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | posttranscriptional gene silencing by RNA |
| REAC:R-HSA-73894 | 1.36038913039e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | DNA Repair |
| GO:0016441 | 1.38881233502e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | posttranscriptional gene silencing |
| REAC:R-HSA-5663202 | 1.91091086177e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Diseases of signal transduction |
| GO:0031047 | 2.20318804036e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | gene silencing by RNA |
| REAC:R-HSA-3700989 | 2.39115386669e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Transcriptional Regulation by TP53 |
| REAC:R-HSA-5663205 | 2.9136265514e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Infectious disease |
| REAC:R-HSA-73980 | 3.10436952437e-07 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase III Transcription Termination |
| GO:0006367 | 3.5407337924e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | transcription initiation from RNA polymerase II promoter |
| GO:0019083 | 3.69098671288e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | viral transcription |
| GO:0050792 | 5.73905505782e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of viral process |
| REAC:R-HSA-76066 | 6.14338829959e-07 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase III Transcription Initiation From Type 2 Promoter |
| REAC:R-HSA-9006934 | 7.11877233268e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Signaling by Receptor Tyrosine Kinases |
| REAC:R-HSA-76071 | 7.164588297e-07 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase III Transcription Initiation From Type 3 Promoter |
| REAC:R-HSA-76061 | 7.164588297e-07 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase III Transcription Initiation From Type 1 Promoter |
| GO:0019080 | 7.21879219491e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | viral gene expression |
| GO:0043903 | 9.34676904569e-07 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of symbiosis, encompassing mutualism through parasitism |
| REAC:R-HSA-73857 | 1.0138617583e-06 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | RNA Polymerase II Transcription |
| REAC:R-HSA-73863 | 1.09977660223e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase I Transcription Termination |
| GO:0006352 | 1.52475390675e-06 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | DNA-templated transcription, initiation |
| GO:0001055 | 1.68680065522e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA polymerase II activity |
| GO:0006397 | 1.86553771789e-06 | 0.727272727273 | POLR2E POLR2F RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | mRNA processing |
| REAC:R-HSA-76046 | 2.05499665717e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase III Transcription Initiation |
| GO:1990234 | 2.65527121969e-06 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | transferase complex |
| REAC:R-HSA-74160 | 2.67031412789e-06 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | Gene expression (Transcription) |
| GO:0016458 | 2.90299135645e-06 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | gene silencing |
| KEGG:04623 | 3.01517804412e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-749476 | 3.52632084551e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase III Abortive And Retractive Initiation |
| REAC:R-HSA-74158 | 3.52632084551e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase III Transcription |
| GO:0005736 | 5.73667537032e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA polymerase I complex |
| GO:0001054 | 5.73667537032e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA polymerase I activity |
| REAC:R-HSA-73762 | 6.19682028524e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase I Transcription Initiation |
| WP:WP4655 | 8.66046957519e-06 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | Cytosolic DNA-sensing pathway |
| GO:0001056 | 1.45859703988e-05 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA polymerase III activity |
| GO:0040029 | 1.63790965008e-05 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of gene expression, epigenetic |
| REAC:R-HSA-8953854 | 1.85225458354e-05 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Metabolism of RNA |
| REAC:R-HSA-1834949 | 2.05703737594e-05 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | Cytosolic sensors of pathogen-associated DNA |
| GO:0140098 | 2.32301762003e-05 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | catalytic activity, acting on RNA |
| GO:0005666 | 2.45052124229e-05 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA polymerase III complex |
| GO:0000377 | 2.54243097558e-05 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 2.54243097558e-05 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | mRNA splicing, via spliceosome |
| GO:0000375 | 2.71838840465e-05 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA splicing, via transesterification reactions |
| GO:0044451 | 3.06839766151e-05 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | nucleoplasm part |
| REAC:R-HSA-5250924 | 8.34948143766e-05 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | B-WICH complex positively regulates rRNA expression |
| GO:0008380 | 8.35959996597e-05 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | RNA splicing |
| REAC:R-HSA-73772 | 8.73453192841e-05 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase I Promoter Escape |
| REAC:R-HSA-5250913 | 0.000156351359814 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 0.000162482115197 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | NoRC negatively regulates rRNA expression |
| GO:0071363 | 0.000176690067356 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | cellular response to growth factor stimulus |
| REAC:R-HSA-5250941 | 0.00018195169909 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 0.000188811857171 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase I Promoter Clearance |
| GO:0006362 | 0.000189417697176 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | transcription elongation from RNA polymerase I promoter |
| GO:0016071 | 0.000192651560343 | 0.727272727273 | POLR2E POLR2F RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | mRNA metabolic process |
| REAC:R-HSA-73864 | 0.000195862830785 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | RNA Polymerase I Transcription |
| REAC:R-HSA-1266738 | 0.000196415244238 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Developmental Biology |
| GO:0043902 | 0.000205326001066 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | positive regulation of multi-organism process |
| GO:0070848 | 0.00022653987007 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | response to growth factor |
| REAC:R-HSA-1643685 | 0.000240712989918 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Disease |
| GO:0006363 | 0.000250749065309 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | termination of RNA polymerase I transcription |
| GO:0016032 | 0.000257711845166 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | viral process |
| GO:0006361 | 0.000286462466462 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | transcription initiation from RNA polymerase I promoter |
| GO:1902494 | 0.00031759147892 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | catalytic complex |
| GO:0006281 | 0.000352067950646 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | DNA repair |
| GO:0006396 | 0.000361003779895 | 0.727272727273 | POLR2E POLR2F RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | RNA processing |
| REAC:R-HSA-212436 | 0.000430416969335 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Generic Transcription Pathway |
| GO:0044403 | 0.000502798125407 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | symbiotic process |
| GO:0010608 | 0.000596796193371 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | posttranscriptional regulation of gene expression |
| REAC:R-HSA-212165 | 0.000607902960483 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | Epigenetic regulation of gene expression |
| GO:0044419 | 0.000735004037611 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | interspecies interaction between organisms |
| GO:0007169 | 0.000797459259432 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | transmembrane receptor protein tyrosine kinase signaling pathway |
| GO:0043900 | 0.00190949859623 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | regulation of multi-organism process |
| GO:0006366 | 0.00317140457228 | 0.818181818182 | POLR2E POLR2F RPAP2 RPRD1B POLR2D POLR2L POLR2G POLR2I POLR2H | transcription by RNA polymerase II |
| GO:0045815 | 0.00358890152673 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | positive regulation of gene expression, epigenetic |
| GO:0006360 | 0.00358890152673 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | transcription by RNA polymerase I |
| GO:0032481 | 0.0050008289462 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | positive regulation of type I interferon production |
| GO:0007167 | 0.00758065267518 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | enzyme linked receptor protein signaling pathway |
| GO:0006259 | 0.00765415498856 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | DNA metabolic process |
| GO:0006974 | 0.00772826194743 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | cellular response to DNA damage stimulus |
| GO:0006353 | 0.00853763565651 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | DNA-templated transcription, termination |
| CORUM:5233 | 0.00917874943703 | 0.181818181818 | POLR2H POLR2L | TNF-alpha/NF-kappa B signaling complex 5 |
| GO:0016772 | 0.0138093161249 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | transferase activity, transferring phosphorus-containing groups |
| GO:0071495 | 0.0289971506624 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | cellular response to endogenous stimulus |
| REAC:R-HSA-162582 | 0.0306388368258 | 0.636363636364 | POLR2E POLR2F POLR2D POLR2L POLR2G POLR2I POLR2H | Signal Transduction |
| GO:0032479 | 0.0329707759671 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | regulation of type I interferon production |
| GO:0032606 | 0.0342899765218 | 0.363636363636 | POLR2H POLR2L POLR2F POLR2E | type I interferon production |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLR2D | POLR2G | 1.0 | 0.949 | hein_WMM bioplex (POLR2D,POLR2G) bioplex_WMM youn_WMM hein (POLR2G) Malo fraction |
| POLR2G | RPAP2 | 1.0 | 0.949 | hein_WMM bioplex (POLR2G) bioplex_WMM youn_WMM hein (POLR2G) |
| POLR2H | POLR2E | 1.0 | 0.949 | hein_WMM bioplex (POLR2E) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| POLR2G | POLR2I | 1.0 | 0.949 | hein_WMM bioplex (POLR2G) bioplex_WMM youn_WMM hein (POLR2G) |
| POLR2I | POLR2L | 1.0 | 0.949 | bioplex_WMM youn_WMM Malo fraction |
| POLR2G | POLR2L | 1.0 | 0.949 | bioplex (POLR2G) bioplex_WMM youn_WMM Malo fraction |
| POLR2F | POLR2E | 1.0 | 0.949 | hein_WMM bioplex (POLR2E) bioplex_WMM youn_WMM hein (POLR2F) fraction |
| POLR2D | POLR2I | 0.997 | 0.931 | hein_WMM bioplex_WMM youn_WMM Malo fraction |
| RPRD1B | POLR2I | 0.995 | 0.924 | hein_WMM bioplex (RPRD1B) bioplex_WMM youn_WMM hein (RPRD1B) |
| POLR2D | RPRD1B | 0.992 | 0.912 | hein_WMM bioplex (POLR2D,RPRD1B) bioplex_WMM youn_WMM hein (RPRD1B) |
| POLR2E | POLR2L | 0.988 | 0.901 | bioplex (POLR2E) bioplex_WMM youn_WMM fraction |
| POLR2F | POLR2H | 0.988 | 0.901 | hein_WMM bioplex_WMM youn_WMM hein (POLR2F) fraction |
| POLR2E | POLR2I | 0.988 | 0.901 | hein_WMM bioplex (POLR2E) bioplex_WMM youn_WMM fraction |
| POLR2G | POLR2E | 0.988 | 0.901 | hein_WMM bioplex (POLR2E,POLR2G) bioplex_WMM youn_WMM hein (POLR2G) fraction |
| POLR2F | POLR2I | 0.987 | 0.902 | hein_WMM bioplex_WMM youn_WMM hein (POLR2F) fraction |
| POLR2G | RPRD1B | 0.986 | 0.901 | hein_WMM bioplex (POLR2G,RPRD1B) bioplex_WMM youn_WMM hein (RPRD1B) |
| GPN1 | POLR2G | 0.977 | 0.893 | hein_WMM bioplex (POLR2G) bioplex_WMM hein (POLR2G) |
| POLR2G | POLR2H | 0.973 | 0.886 | hein_WMM bioplex (POLR2G) bioplex_WMM youn_WMM hein (POLR2G) |
| GPN3 | POLR2G | 0.967 | 0.879 | hein_WMM bioplex (GPN3,POLR2G) bioplex_WMM hein (POLR2G) |
| RPAP2 | RPRD1B | 0.936 | 0.85 | hein_WMM bioplex (RPRD1B) bioplex_WMM youn_WMM hein (RPRD1B) gupta_WMM |
| POLR2F | POLR2G | 0.925 | 0.843 | hein_WMM bioplex (POLR2G) bioplex_WMM youn_WMM hein (POLR2F) |
| GPN3 | RPAP2 | 0.9 | 0.825 | hein_WMM bioplex (GPN3) bioplex_WMM youn_WMM |
| POLR2H | POLR2I | 0.823 | 0.774 | hein_WMM bioplex_WMM youn_WMM fraction |
| GPN1 | GPN3 | 0.812 | 0.772 | hein_WMM bioplex (GPN3) bioplex_WMM youn_WMM |
| POLR2F | GPN3 | 0.668 | 0.702 | hein_WMM bioplex (GPN3) bioplex_WMM hein (POLR2F) fraction |
| POLR2D | RPAP2 | 0.324 | 0.513 | hein_WMM bioplex (POLR2D) bioplex_WMM youn_WMM |
| POLR2D | POLR2E | 0.314 | 0.508 | hein_WMM bioplex (POLR2D,POLR2E) bioplex_WMM youn_WMM fraction |
| POLR2H | POLR2L | 0.232 | 0.47 | hein_WMM bioplex_WMM youn_WMM fraction |
| GPN3 | POLR2I | 0.183 | 0.437 | hein_WMM bioplex (GPN3) bioplex_WMM youn_WMM |
| RPAP2 | POLR2E | 0.164 | 0.42 | hein_WMM bioplex (POLR2E) bioplex_WMM youn_WMM gupta_WMM |
| GPN3 | POLR2D | 0.15 | 0.41 | hein_WMM bioplex (GPN3,POLR2D) bioplex_WMM |
| RPRD1B | POLR2L | 0.127 | 0.398 | bioplex (RPRD1B) bioplex_WMM youn_WMM |
| GPN1 | POLR2E | 0.127 | 0.398 | hein_WMM bioplex (POLR2E) bioplex_WMM youn_WMM gupta_WMM |
| GPN3 | POLR2E | 0.072 | 0.353 | hein_WMM bioplex (GPN3,POLR2E) bioplex_WMM youn_WMM |
| GPN3 | RPRD1B | 0.066 | 0.347 | bioplex (RPRD1B) bioplex_WMM youn_WMM |
| RPRD1B | POLR2E | 0.065 | 0.347 | bioplex (RPRD1B) bioplex_WMM youn_WMM gupta_WMM fraction |
| POLR2D | POLR2L | 0.043 | 0.27 | bioplex (POLR2D) bioplex_WMM youn_WMM |
| RPAP2 | POLR2I | 0.038 | 0.265 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| POLR2D | POLR2H | 0.032 | 0.245 | hein_WMM bioplex (POLR2D) bioplex_WMM youn_WMM |
| GPN1 | POLR2D | 0.028 | 0.231 | hein_WMM bioplex (POLR2D) bioplex_WMM |
| POLR2F | POLR2D | 0.025 | 0.211 | bioplex (POLR2D) bioplex_WMM youn_WMM |
| GPN1 | RPAP2 | 0.025 | 0.211 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GPN3 | POLR2H | 0.022 | 0.198 | hein_WMM bioplex (GPN3) bioplex_WMM youn_WMM fraction |
| GPN1 | POLR2L | 0.02 | 0.189 | bioplex_WMM WMM_only |
| GPN1 | POLR2F | 0.019 | 0.181 | hein_WMM bioplex_WMM hein (POLR2F) |
| POLR2H | RPAP2 | 0.017 | 0.173 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| POLR2F | RPAP2 | 0.016 | 0.164 | hein_WMM bioplex_WMM youn_WMM hein (POLR2F) |
| GPN1 | POLR2H | 0.016 | 0.155 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| GPN1 | POLR2I | 0.015 | 0.146 | hein_WMM bioplex_WMM WMM_only |
| RPAP2 | POLR2L | 0.012 | 0.147 | bioplex_WMM youn_WMM WMM_only |
| POLR2F | POLR2L | 0.01 | 0.103 | bioplex_WMM youn_WMM WMM_only |
| GPN3 | POLR2L | 0.005 | 0.008 | bioplex (GPN3) bioplex_WMM |
| GPN1 | RPRD1B | 0.003 | 0.02 | bioplex (RPRD1B) bioplex_WMM youn_WMM |
| POLR2F | RPRD1B | 0.0 | 0.008 | bioplex (RPRD1B) bioplex_WMM youn_WMM |
| POLR2H | RPRD1B | 0.0 | 0.008 | bioplex (RPRD1B) bioplex_WMM youn_WMM gupta_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_05703 has an average edge precision of 0.541 which is ranked 2259 out of all 6965 complexes.
Related Complexes