hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05704
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SHC2 | SHC-transforming protein 2 (Protein Sck) (SHC-transforming protein B) (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) | UniProt NCBI |
| SHC1 | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-167044 | 0.000227925590883 | 1.0 | SHC2 SHC1 | Signalling to RAS |
| KEGG:04917 | 0.00027589225596 | 1.0 | SHC2 SHC1 | Prolactin signaling pathway |
| KEGG:05214 | 0.000332354605541 | 1.0 | SHC2 SHC1 | Glioma |
| KEGG:05100 | 0.000383418745988 | 1.0 | SHC2 SHC1 | Bacterial invasion of epithelial cells |
| KEGG:01521 | 0.00039406926671 | 1.0 | SHC2 SHC1 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05220 | 0.00039406926671 | 1.0 | SHC2 SHC1 | Chronic myeloid leukemia |
| KEGG:04012 | 0.000449510333482 | 1.0 | SHC2 SHC1 | ErbB signaling pathway |
| KEGG:01522 | 0.000584319664263 | 1.0 | SHC2 SHC1 | Endocrine resistance |
| REAC:R-HSA-187687 | 0.000680424925724 | 1.0 | SHC2 SHC1 | Signalling to ERKs |
| KEGG:04650 | 0.000707748986601 | 1.0 | SHC2 SHC1 | Natural killer cell mediated cytotoxicity |
| KEGG:04722 | 0.000827384972793 | 1.0 | SHC2 SHC1 | Neurotrophin signaling pathway |
| KEGG:04926 | 0.00104170846513 | 1.0 | SHC2 SHC1 | Relaxin signaling pathway |
| KEGG:04915 | 0.00107686977326 | 1.0 | SHC2 SHC1 | Estrogen signaling pathway |
| KEGG:04910 | 0.00113070596705 | 1.0 | SHC2 SHC1 | Insulin signaling pathway |
| KEGG:04072 | 0.00114894316007 | 1.0 | SHC2 SHC1 | Phospholipase D signaling pathway |
| KEGG:04062 | 0.00122335090758 | 1.0 | SHC2 SHC1 | Chemokine signaling pathway |
| KEGG:05224 | 0.00122335090758 | 1.0 | SHC2 SHC1 | Breast cancer |
| KEGG:05226 | 0.00124231758831 | 1.0 | SHC2 SHC1 | Gastric cancer |
| WP:WP673 | 0.00133011535423 | 1.0 | SHC2 SHC1 | ErbB Signaling Pathway |
| KEGG:05225 | 0.00183261905189 | 1.0 | SHC2 SHC1 | Hepatocellular carcinoma |
| KEGG:05034 | 0.00199806686694 | 1.0 | SHC2 SHC1 | Alcoholism |
| KEGG:04014 | 0.00245633105307 | 1.0 | SHC2 SHC1 | Ras signaling pathway |
| KEGG:04510 | 0.00259201576911 | 1.0 | SHC2 SHC1 | Focal adhesion |
| WP:WP3915 | 0.00284130523568 | 1.0 | SHC2 SHC1 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP3929 | 0.00284130523568 | 1.0 | SHC2 SHC1 | Chemokine signaling pathway |
| WP:WP2380 | 0.00342029662517 | 1.0 | SHC2 SHC1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| WP:WP4262 | 0.00357342755251 | 1.0 | SHC2 SHC1 | Breast cancer pathway |
| WP:WP481 | 0.00438938066897 | 1.0 | SHC2 SHC1 | Insulin Signaling |
| REAC:R-HSA-187037 | 0.00440432685912 | 1.0 | SHC2 SHC1 | Signaling by NTRK1 (TRKA) |
| WP:WP4223 | 0.00444675819405 | 1.0 | SHC2 SHC1 | Ras Signaling |
| WP:WP306 | 0.00654923464894 | 1.0 | SHC2 SHC1 | Focal Adhesion |
| REAC:R-HSA-166520 | 0.00686290657842 | 1.0 | SHC2 SHC1 | Signaling by NTRKs |
| WP:WP3888 | 0.00889388896944 | 1.0 | SHC2 SHC1 | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-5673001 | 0.0313749631391 | 1.0 | SHC2 SHC1 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0330173681322 | 1.0 | SHC2 SHC1 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-9607240 | 0.0371300843089 | 1.0 | SHC2 SHC1 | FLT3 Signaling |
| REAC:R-HSA-449836 | 0.0429891127334 | 1.0 | SHC2 SHC1 | Other interleukin signaling |
| REAC:R-HSA-5683057 | 0.0464733576116 | 1.0 | SHC2 SHC1 | MAPK family signaling cascades |
| CORUM:2895 | 0.0499173803268 | 0.5 | SHC1 | SHC-GRB2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SHC2 | SHC1 | 1.0 | 0.949 | bioplex (SHC1) bioplex_WMM |
Images
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Complex HuMAP2_05704 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SHC2 | HuMAP2_01597 HuMAP2_04831 HuMAP2_05704 |
| SHC1 | HuMAP2_01597 HuMAP2_04831 HuMAP2_05704 |