hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05706
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKAR1A | cAMP-dependent protein kinase type I-alpha regulatory subunit (Tissue-specific extinguisher 1) (TSE1) | UniProt NCBI |
| AKAP3 | A-kinase anchor protein 3 (AKAP-3) (A-kinase anchor protein 110 kDa) (AKAP 110) (Cancer/testis antigen 82) (CT82) (Fibrous sheath protein of 95 kDa) (FSP95) (Fibrousheathin I) (Fibrousheathin-1) (Protein kinase A-anchoring protein 3) (PRKA3) (Sperm oocyte-binding protein) | UniProt NCBI |
| GPR161 | G-protein coupled receptor 161 (G-protein coupled receptor RE2) | UniProt NCBI |
| PRKAR1B | cAMP-dependent protein kinase type I-beta regulatory subunit | UniProt NCBI |
| C2orf88 | Small membrane A-kinase anchor protein (Small membrane AKAP) (smAKAP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP35 | 7.07040269841e-05 | 0.6 | PRKAR1B PRKAR1A AKAP3 | G Protein Signaling Pathways |
| REAC:R-HSA-5610787 | 0.000596598643168 | 0.6 | PRKAR1B GPR161 PRKAR1A | Hedgehog 'off' state |
| REAC:R-HSA-442720 | 0.000741476933235 | 0.4 | PRKAR1B PRKAR1A | CREB1 phosphorylation through the activation of Adenylate Cyclase |
| WP:WP3869 | 0.000842496056343 | 0.4 | PRKAR1B PRKAR1A | Cannabinoid receptor signaling |
| WP:WP2012 | 0.00108182147376 | 0.4 | PRKAR1B PRKAR1A | miRs in Muscle Cell Differentiation |
| REAC:R-HSA-5358351 | 0.00125259730234 | 0.6 | PRKAR1B GPR161 PRKAR1A | Signaling by Hedgehog |
| WP:WP3965 | 0.00125790337124 | 0.4 | PRKAR1B PRKAR1A | Lipid Metabolism Pathway |
| REAC:R-HSA-163615 | 0.00161668141155 | 0.4 | PRKAR1B PRKAR1A | PKA activation |
| REAC:R-HSA-164378 | 0.00183199274719 | 0.4 | PRKAR1B PRKAR1A | PKA activation in glucagon signalling |
| REAC:R-HSA-111931 | 0.00206071490935 | 0.4 | PRKAR1B PRKAR1A | PKA-mediated phosphorylation of CREB |
| REAC:R-HSA-180024 | 0.00340529843133 | 0.4 | PRKAR1B PRKAR1A | DARPP-32 events |
| REAC:R-HSA-163359 | 0.00625202329777 | 0.4 | PRKAR1B PRKAR1A | Glucagon signaling in metabolic regulation |
| REAC:R-HSA-111997 | 0.00709716303977 | 0.4 | PRKAR1B PRKAR1A | CaM pathway |
| REAC:R-HSA-111933 | 0.00709716303977 | 0.4 | PRKAR1B PRKAR1A | Calmodulin induced events |
| REAC:R-HSA-381676 | 0.00799559968784 | 0.4 | PRKAR1B PRKAR1A | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| REAC:R-HSA-111996 | 0.00799559968784 | 0.4 | PRKAR1B PRKAR1A | Ca-dependent events |
| REAC:R-HSA-432040 | 0.00894729002053 | 0.4 | PRKAR1B PRKAR1A | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-1489509 | 0.00995219083388 | 0.4 | PRKAR1B PRKAR1A | DAG and IP3 signaling |
| REAC:R-HSA-445717 | 0.00995219083388 | 0.4 | PRKAR1B PRKAR1A | Aquaporin-mediated transport |
| GO:0051018 | 0.0103850554114 | 0.6 | PRKAR1B PRKAR1A AKAP3 | protein kinase A binding |
| WP:WP4540 | 0.0123508080289 | 0.4 | PRKAR1B PRKAR1A | Pathways Regulating Hippo Signaling |
| WP:WP4541 | 0.0169715520461 | 0.4 | PRKAR1B PRKAR1A | Hippo-Merlin Signaling Dysregulation |
| REAC:R-HSA-112043 | 0.0170965985867 | 0.4 | PRKAR1B PRKAR1A | PLC beta mediated events |
| REAC:R-HSA-112040 | 0.017778070678 | 0.4 | PRKAR1B PRKAR1A | G-protein mediated events |
| WP:WP536 | 0.0234679122485 | 0.4 | PRKAR1B PRKAR1A | Calcium Regulation in the Cardiac Cell |
| WP:WP706 | 0.0266864861787 | 0.4 | PRKAR1B PRKAR1A | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| WP:WP289 | 0.0279458043607 | 0.4 | PRKAR1B PRKAR1A | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-422356 | 0.0313816354582 | 0.4 | PRKAR1B PRKAR1A | Regulation of insulin secretion |
| KEGG:04910 | 0.0327287628992 | 0.4 | PRKAR1B PRKAR1A | Insulin signaling pathway |
| REAC:R-HSA-438064 | 0.0351349281697 | 0.4 | PRKAR1B PRKAR1A | Post NMDA receptor activation events |
| REAC:R-HSA-442755 | 0.0465369402216 | 0.4 | PRKAR1B PRKAR1A | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-111885 | 0.0487798927038 | 0.4 | PRKAR1B PRKAR1A | Opioid Signalling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRKAR1A | PRKAR1B | 1.0 | 0.949 | hein_WMM bioplex (PRKAR1A) bioplex_WMM |
| PRKAR1A | AKAP3 | 0.969 | 0.881 | bioplex (PRKAR1A) bioplex_WMM |
| PRKAR1A | GPR161 | 0.74 | 0.739 | bioplex (GPR161,PRKAR1A) bioplex_WMM |
| PRKAR1A | C2orf88 | 0.37 | 0.545 | bioplex (PRKAR1A) bioplex_WMM |
| PRKAR1B | GPR161 | 0.076 | 0.355 | bioplex (GPR161) bioplex_WMM |
| GPR161 | AKAP3 | 0.009 | 0.102 | bioplex_WMM WMM_only |
| AKAP3 | C2orf88 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| GPR161 | C2orf88 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| PRKAR1B | AKAP3 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| PRKAR1B | C2orf88 | 0.008 | 0.039 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05706 has an average edge precision of 0.385 which is ranked 3467 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKAR1A | HuMAP2_00037 HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 HuMAP2_04753 HuMAP2_05706 |
| AKAP3 | HuMAP2_02640 HuMAP2_04753 HuMAP2_05706 |
| GPR161 | HuMAP2_02640 HuMAP2_04753 HuMAP2_05706 |
| PRKAR1B | HuMAP2_02640 HuMAP2_03596 HuMAP2_04684 HuMAP2_04753 HuMAP2_05706 |
| C2orf88 | HuMAP2_04753 HuMAP2_05706 |