hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05711
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SRSF1 | Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit) | UniProt NCBI |
| SRSF3 | Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3) | UniProt NCBI |
| SRSF9 | Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9) | UniProt NCBI |
| SRRM1 | Serine/arginine repetitive matrix protein 1 (SR-related nuclear matrix protein of 160 kDa) (SRm160) (Ser/Arg-related nuclear matrix protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72187 | 2.86807459968e-08 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 5.40207511254e-08 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA Polymerase II Transcription Termination |
| REAC:R-HSA-159236 | 7.38564283704e-08 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 1.22728265013e-07 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | Transport of Mature Transcript to Cytoplasm |
| WP:WP411 | 1.46848778508e-07 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA Processing |
| CORUM:351 | 6.95120006013e-07 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | Spliceosome |
| REAC:R-HSA-72163 | 3.66683425084e-06 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 4.37825325788e-06 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA Splicing |
| REAC:R-HSA-72203 | 1.12324610099e-05 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0031124 | 7.12285743241e-05 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA 3'-end processing |
| KEGG:03040 | 9.56545898299e-05 | 0.75 | SRSF1 SRSF3 SRSF9 | Spliceosome |
| GO:0006406 | 0.000125895977869 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA export from nucleus |
| GO:0071427 | 0.000125895977869 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0051028 | 0.000151516440356 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA transport |
| GO:0071426 | 0.000214275729623 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | ribonucleoprotein complex export from nucleus |
| GO:0071166 | 0.000221478275157 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | ribonucleoprotein complex localization |
| GO:0006405 | 0.000285834009959 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA export from nucleus |
| GO:0031123 | 0.000313257328826 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA 3'-end processing |
| GO:0050657 | 0.000494260781771 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | nucleic acid transport |
| GO:0050658 | 0.000494260781771 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA transport |
| GO:0051236 | 0.000535430121219 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | establishment of RNA localization |
| GO:0006611 | 0.000609694967109 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | protein export from nucleus |
| REAC:R-HSA-8953854 | 0.000676603019954 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | Metabolism of RNA |
| GO:0051168 | 0.000819333954364 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | nuclear export |
| GO:0015931 | 0.000879263724448 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | nucleobase-containing compound transport |
| GO:0045292 | 0.00106129291317 | 0.75 | SRSF1 SRSF3 SRSF9 | mRNA cis splicing, via spliceosome |
| GO:0006403 | 0.00117775012637 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA localization |
| CORUM:1183 | 0.00203634341963 | 0.5 | SRSF1 SRRM1 | CDC5L complex |
| KEGG:05168 | 0.00237639508828 | 0.75 | SRSF1 SRSF3 SRSF9 | Herpes simplex virus 1 infection |
| GO:0031503 | 0.00272272763799 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | protein-containing complex localization |
| HPA:006020_13 | 0.00503181450466 | 0.75 | SRSF1 SRRM1 SRSF3 | caudate; neuronal cells[Supported,High] |
| GO:0006913 | 0.00512711596139 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | nucleocytoplasmic transport |
| GO:0051169 | 0.0053619122614 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | nuclear transport |
| HPA:035010_13 | 0.005495872704 | 0.75 | SRSF1 SRRM1 SRSF3 | placenta; decidual cells[Supported,High] |
| HPA:058010_13 | 0.00644817227818 | 0.75 | SRSF1 SRRM1 SRSF3 | vagina; squamous epithelial cells[Supported,High] |
| HPA:007030_13 | 0.0066268155894 | 0.75 | SRSF1 SRRM1 SRSF3 | cerebellum; cells in molecular layer[Supported,High] |
| REAC:R-HSA-73857 | 0.00664358115488 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA Polymerase II Transcription |
| HPA:040010_13 | 0.00705633972179 | 0.75 | SRSF1 SRRM1 SRSF3 | seminal vesicle; glandular cells[Supported,High] |
| GO:0016607 | 0.00713971525321 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | nuclear speck |
| HPA:007010_13 | 0.00718236211525 | 0.75 | SRSF1 SRRM1 SRSF3 | cerebellum; Purkinje cells[Supported,High] |
| HPA:004020_13 | 0.00730986723989 | 0.75 | SRSF1 SRRM1 SRSF3 | breast; glandular cells[Supported,High] |
| HPA:009010_13 | 0.00743886355825 | 0.75 | SRSF1 SRRM1 SRSF3 | cervix, uterine; glandular cells[Supported,High] |
| HPA:030010_13 | 0.00810650898749 | 0.75 | SRSF1 SRRM1 SRSF3 | oral mucosa; squamous epithelial cells[Supported,High] |
| HPA:031010_12 | 0.00831427131638 | 0.75 | SRSF1 SRRM1 SRSF3 | ovary; follicle cells[Supported,Medium] |
| GO:0000377 | 0.00944788787297 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.00944788787297 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA splicing, via spliceosome |
| GO:0000375 | 0.00981835447646 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA splicing, via transesterification reactions |
| HPA:044010_13 | 0.0100254167787 | 0.75 | SRSF1 SRRM1 SRSF3 | skin 2; epidermal cells[Supported,High] |
| HPA:039010_13 | 0.0101046758484 | 0.75 | SRSF1 SRRM1 SRSF3 | salivary gland; glandular cells[Supported,High] |
| HPA:047010_12 | 0.0101843487884 | 0.75 | SRSF1 SRRM1 SRSF3 | soft tissue 1; adipocytes[Supported,Medium] |
| REAC:R-HSA-74160 | 0.0102868657133 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | Gene expression (Transcription) |
| GO:0000381 | 0.011776375189 | 0.75 | SRSF1 SRSF3 SRSF9 | regulation of alternative mRNA splicing, via spliceosome |
| HPA:004010_12 | 0.0117781632296 | 0.75 | SRSF1 SRRM1 SRSF3 | breast; adipocytes[Supported,Medium] |
| HPA:002010_13 | 0.0125874733426 | 0.75 | SRSF1 SRRM1 SRSF3 | appendix; glandular cells[Supported,High] |
| HPA:016010_13 | 0.0125874733426 | 0.75 | SRSF1 SRRM1 SRSF3 | esophagus; squamous epithelial cells[Supported,High] |
| HPA:008030_13 | 0.0129586703655 | 0.75 | SRSF1 SRRM1 SRSF3 | cerebral cortex; neuronal cells[Supported,High] |
| HPA:015010_13 | 0.0135289372622 | 0.75 | SRSF1 SRRM1 SRSF3 | epididymis; glandular cells[Supported,High] |
| HPA:024020_13 | 0.0137226518885 | 0.75 | SRSF1 SRRM1 SRSF3 | kidney; cells in tubules[Supported,High] |
| HPA:048010_12 | 0.0148209572751 | 0.75 | SRSF1 SRRM1 SRSF3 | soft tissue 2; adipocytes[Supported,Medium] |
| CORUM:1181 | 0.0149958507614 | 0.5 | SRSF1 SRRM1 | C complex spliceosome |
| HPA:031010_11 | 0.0164101932347 | 0.75 | SRSF1 SRRM1 SRSF3 | ovary; follicle cells[Supported,Low] |
| HPA:006020_03 | 0.01651997263 | 0.75 | SRSF1 SRRM1 SRSF3 | caudate; neuronal cells[Uncertain,High] |
| HPA:007030_03 | 0.01651997263 | 0.75 | SRSF1 SRRM1 SRSF3 | cerebellum; cells in molecular layer[Uncertain,High] |
| HPA:053020_13 | 0.017188862818 | 0.75 | SRSF1 SRRM1 SRSF3 | testis; cells in seminiferous ducts[Supported,High] |
| GO:0000380 | 0.017346559408 | 0.75 | SRSF1 SRSF3 SRSF9 | alternative mRNA splicing, via spliceosome |
| HPA:035010_03 | 0.0186990413257 | 0.75 | SRSF1 SRRM1 SRSF3 | placenta; decidual cells[Uncertain,High] |
| GO:0008380 | 0.0187431053955 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | RNA splicing |
| HPA:057010_13 | 0.0188187097484 | 0.75 | SRSF1 SRRM1 SRSF3 | urinary bladder; urothelial cells[Supported,High] |
| HPA:032010_13 | 0.0201686361907 | 0.75 | SRSF1 SRRM1 SRSF3 | pancreas; exocrine glandular cells[Supported,High] |
| HPA:022010_12 | 0.0205475883704 | 0.75 | SRSF1 SRRM1 SRSF3 | hippocampus; glial cells[Supported,Medium] |
| HPA:018010_13 | 0.0209312173501 | 0.75 | SRSF1 SRRM1 SRSF3 | fallopian tube; glandular cells[Supported,High] |
| HPA:029010_13 | 0.0210601377494 | 0.75 | SRSF1 SRRM1 SRSF3 | nasopharynx; respiratory epithelial cells[Supported,High] |
| HPA:005010_13 | 0.0211895818928 | 0.75 | SRSF1 SRRM1 SRSF3 | bronchus; respiratory epithelial cells[Supported,High] |
| HPA:058010_03 | 0.0217126163903 | 0.75 | SRSF1 SRRM1 SRSF3 | vagina; squamous epithelial cells[Uncertain,High] |
| HPA:045010_13 | 0.0234712568487 | 0.75 | SRSF1 SRRM1 SRSF3 | small intestine; glandular cells[Supported,High] |
| HPA:051010_13 | 0.0237498929607 | 0.75 | SRSF1 SRRM1 SRSF3 | stomach 1; glandular cells[Supported,High] |
| HPA:011020_13 | 0.0244560243519 | 0.75 | SRSF1 SRRM1 SRSF3 | colon; glandular cells[Supported,High] |
| HPA:030010_03 | 0.0244560243519 | 0.75 | SRSF1 SRRM1 SRSF3 | oral mucosa; squamous epithelial cells[Uncertain,High] |
| GO:0006397 | 0.0251226492241 | 1.0 | SRSF1 SRSF9 SRRM1 SRSF3 | mRNA processing |
| MIRNA:hsa-miR-5583-5p | 0.0251458742969 | 0.5 | SRSF1 SRSF3 | hsa-miR-5583-5p |
| MIRNA:hsa-miR-3129-3p | 0.0251458742969 | 0.5 | SRSF1 SRSF3 | hsa-miR-3129-3p |
| HPA:035020_13 | 0.025175887812 | 0.75 | SRSF1 SRRM1 SRSF3 | placenta; trophoblastic cells[Supported,High] |
| HPA:006010_12 | 0.0254677066879 | 0.75 | SRSF1 SRRM1 SRSF3 | caudate; glial cells[Supported,Medium] |
| HPA:013010_12 | 0.02561445023 | 0.75 | SRSF1 SRRM1 SRSF3 | endometrium 1; cells in endometrial stroma[Supported,Medium] |
| HPA:031020_12 | 0.0259096106078 | 0.75 | SRSF1 SRRM1 SRSF3 | ovary; ovarian stroma cells[Supported,Medium] |
| HPA:048030_12 | 0.026506652998 | 0.75 | SRSF1 SRRM1 SRSF3 | soft tissue 2; fibroblasts[Supported,Medium] |
| HPA:009010_03 | 0.026657319863 | 0.75 | SRSF1 SRRM1 SRSF3 | cervix, uterine; glandular cells[Uncertain,High] |
| HPA:047030_12 | 0.0281952055319 | 0.75 | SRSF1 SRRM1 SRSF3 | soft tissue 1; fibroblasts[Supported,Medium] |
| HPA:012010_13 | 0.0283521381117 | 0.75 | SRSF1 SRRM1 SRSF3 | duodenum; glandular cells[Supported,High] |
| HPA:037010_13 | 0.0296284087039 | 0.75 | SRSF1 SRRM1 SRSF3 | rectum; glandular cells[Supported,High] |
| HPA:048040_11 | 0.0306101023554 | 0.75 | SRSF1 SRRM1 SRSF3 | soft tissue 2; peripheral nerve[Supported,Low] |
| HPA:011030_12 | 0.0312763482879 | 0.75 | SRSF1 SRRM1 SRSF3 | colon; peripheral nerve/ganglion[Supported,Medium] |
| HPA:040010_03 | 0.031444391961 | 0.75 | SRSF1 SRRM1 SRSF3 | seminal vesicle; glandular cells[Uncertain,High] |
| HPA:026020_12 | 0.031444391961 | 0.75 | SRSF1 SRRM1 SRSF3 | liver; hepatocytes[Supported,Medium] |
| HPA:046010_12 | 0.0316130305275 | 0.75 | SRSF1 SRRM1 SRSF3 | smooth muscle; smooth muscle cells[Supported,Medium] |
| HPA:004020_03 | 0.0319520963736 | 0.75 | SRSF1 SRRM1 SRSF3 | breast; glandular cells[Uncertain,High] |
| HPA:019010_13 | 0.0338599256539 | 0.75 | SRSF1 SRRM1 SRSF3 | gallbladder; glandular cells[Supported,High] |
| HPA:008020_12 | 0.0340369984952 | 0.75 | SRSF1 SRRM1 SRSF3 | cerebral cortex; glial cells[Supported,Medium] |
| HPA:004010_11 | 0.0342146813303 | 0.75 | SRSF1 SRRM1 SRSF3 | breast; adipocytes[Supported,Low] |
| GO:0048024 | 0.0344730150111 | 0.75 | SRSF1 SRSF3 SRSF9 | regulation of mRNA splicing, via spliceosome |
| HPA:035010_12 | 0.0347513998463 | 0.75 | SRSF1 SRRM1 SRSF3 | placenta; decidual cells[Supported,Medium] |
| HPA:007020_12 | 0.0365805245307 | 0.75 | SRSF1 SRRM1 SRSF3 | cerebellum; cells in granular layer[Supported,Medium] |
| HPA:047010_11 | 0.0382800635721 | 0.75 | SRSF1 SRRM1 SRSF3 | soft tissue 1; adipocytes[Supported,Low] |
| HPA:024010_12 | 0.038664676769 | 0.75 | SRSF1 SRRM1 SRSF3 | kidney; cells in glomeruli[Supported,Medium] |
| HPA:044010_03 | 0.0394415317177 | 0.75 | SRSF1 SRRM1 SRSF3 | skin 2; epidermal cells[Uncertain,High] |
| HPA:050010_12 | 0.0410259794916 | 0.75 | SRSF1 SRRM1 SRSF3 | spleen; cells in red pulp[Supported,Medium] |
| HPA:039010_03 | 0.0416307958449 | 0.75 | SRSF1 SRRM1 SRSF3 | salivary gland; glandular cells[Uncertain,High] |
| HPA:027020_12 | 0.0418336999884 | 0.75 | SRSF1 SRRM1 SRSF3 | lung; pneumocytes[Supported,Medium] |
| HPA:041010_12 | 0.0438987109299 | 0.75 | SRSF1 SRRM1 SRSF3 | skeletal muscle; myocytes[Supported,Medium] |
| HPA:011010_12 | 0.0447431662559 | 0.75 | SRSF1 SRRM1 SRSF3 | colon; endothelial cells[Supported,Medium] |
| HPA:007030_12 | 0.0447431662559 | 0.75 | SRSF1 SRRM1 SRSF3 | cerebellum; cells in molecular layer[Supported,Medium] |
| HPA:007010_03 | 0.0451693794799 | 0.75 | SRSF1 SRRM1 SRSF3 | cerebellum; Purkinje cells[Uncertain,High] |
| HPA:048010_11 | 0.0458137035926 | 0.75 | SRSF1 SRRM1 SRSF3 | soft tissue 2; adipocytes[Supported,Low] |
| HPA:043020_12 | 0.0458137035926 | 0.75 | SRSF1 SRRM1 SRSF3 | skin 1; fibroblasts[Supported,Medium] |
| HPA:006020_12 | 0.0462466007541 | 0.75 | SRSF1 SRRM1 SRSF3 | caudate; neuronal cells[Supported,Medium] |
| HPA:043010_12 | 0.0462466007541 | 0.75 | SRSF1 SRRM1 SRSF3 | skin 1; Langerhans[Supported,Medium] |
| HPA:028010_12 | 0.0466821853682 | 0.75 | SRSF1 SRRM1 SRSF3 | lymph node; germinal center cells[Supported,Medium] |
| CORUM:1195 | 0.0499140284799 | 0.25 | SRRM1 | Exon junction complex (mRNA splicing-dependent) |
| CORUM:2833 | 0.0499140284799 | 0.25 | SRRM1 | SRm160-SRm300 complex |
| CORUM:6073 | 0.0499140284799 | 0.25 | SRSF9 | SRSF9-SRSF6 complex |
| CORUM:6261 | 0.0499140284799 | 0.25 | SRSF1 | Histone-2-Histone-4-ASF1-MCM2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SRSF1 | SRSF3 | 1.0 | 0.949 | bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SRSF1 | SRRM1 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (SRSF1) gupta_WMM fraction |
| SRSF1 | SRSF9 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (SRSF1) Malo gupta_WMM fraction treiber_WMM |
| SRSF9 | SRSF3 | 0.983 | 0.899 | bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| SRRM1 | SRSF3 | 0.973 | 0.886 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SRRM1 | SRSF9 | 0.009 | 0.09 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_05711 has an average edge precision of 0.787 which is ranked 976 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| SRSF1 | HuMAP2_01402 HuMAP2_02261 HuMAP2_02572 HuMAP2_03584 HuMAP2_04668 HuMAP2_05711 HuMAP2_06105 HuMAP2_06517 |
| SRSF3 | HuMAP2_02572 HuMAP2_03584 HuMAP2_04668 HuMAP2_05711 |
| SRSF9 | HuMAP2_02572 HuMAP2_03584 HuMAP2_04668 HuMAP2_05711 |
| SRRM1 | HuMAP2_02572 HuMAP2_03584 HuMAP2_04668 HuMAP2_05711 |