hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05715
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| OTUD4 | OTU domain-containing protein 4 (EC 3.4.19.12) (HIV-1-induced protein HIN-1) | UniProt NCBI |
| TANK | TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF) | UniProt NCBI |
| SNX29 | Sorting nexin-29 (RUN domain-containing protein 2A) | UniProt NCBI |
| TRAF1 | TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) | UniProt NCBI |
| TRAF2 | TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5210 | 2.0123342217e-05 | 0.4 | TRAF2 TANK | TANK-TRAF2-TRAF3 complex |
| WP:WP231 | 7.31920604822e-05 | 0.6 | TRAF1 TANK TRAF2 | TNF alpha Signaling Pathway |
| CORUM:5212 | 0.000187691761896 | 0.4 | TRAF2 TANK | Kinase maturation complex 2 |
| WP:WP3941 | 0.0022136258273 | 0.4 | TRAF1 TRAF2 | Oxidative Damage |
| WP:WP2036 | 0.00259148909572 | 0.4 | TRAF1 TRAF2 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| WP:WP2018 | 0.00439842637514 | 0.4 | TRAF1 TRAF2 | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| WP:WP3865 | 0.00474544100801 | 0.4 | TRAF2 TANK | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| REAC:R-HSA-5357956 | 0.00546022370076 | 0.4 | TRAF1 TRAF2 | TNFR1-induced NFkappaB signaling pathway |
| REAC:R-HSA-933541 | 0.00546022370076 | 0.4 | TRAF2 TANK | TRAF6 mediated IRF7 activation |
| REAC:R-HSA-5357905 | 0.00584945327803 | 0.4 | TRAF1 TRAF2 | Regulation of TNFR1 signaling |
| KEGG:04622 | 0.00858395707223 | 0.4 | TRAF2 TANK | RIG-I-like receptor signaling pathway |
| WP:WP254 | 0.00869264148791 | 0.4 | TRAF1 TRAF2 | Apoptosis |
| REAC:R-HSA-75893 | 0.0104745816743 | 0.4 | TRAF1 TRAF2 | TNF signaling |
| KEGG:04064 | 0.0130921728933 | 0.4 | TRAF1 TRAF2 | NF-kappa B signaling pathway |
| WP:WP4658 | 0.0147251965341 | 0.4 | TRAF1 TRAF2 | Small cell lung cancer |
| KEGG:05222 | 0.0177565608839 | 0.4 | TRAF1 TRAF2 | Small cell lung cancer |
| KEGG:04668 | 0.018144370474 | 0.4 | TRAF1 TRAF2 | TNF signaling pathway |
| KEGG:04210 | 0.0327287628992 | 0.4 | TRAF1 TRAF2 | Apoptosis |
| REAC:R-HSA-168928 | 0.0341769281663 | 0.4 | TRAF2 TANK | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| CORUM:5529 | 0.0499494897235 | 0.2 | TRAF2 | TRAF2-cIAP1/BIRC2 complex |
| CORUM:5540 | 0.0499494897235 | 0.2 | TRAF2 | TRAF2-TRADD complex |
| CORUM:2744 | 0.0499494897235 | 0.2 | TRAF2 | TRAF2-MALT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TANK | TRAF1 | 0.866 | 0.801 | bioplex (TRAF1) bioplex_WMM |
| OTUD4 | TRAF1 | 0.21 | 0.457 | bioplex (TRAF1) bioplex_WMM |
| 84127 | TRAF1 | 0.194 | 0.447 | bioplex (TRAF1) bioplex_WMM |
| TANK | TRAF2 | 0.086 | 0.351 | bioplex (TRAF2) bioplex_WMM |
| TRAF1 | TRAF2 | 0.066 | 0.348 | bioplex (TRAF1,TRAF2) bioplex_WMM |
| SNX29 | TRAF1 | 0.055 | 0.306 | bioplex (TRAF1) bioplex_WMM |
| 84127 | SNX29 | 0.008 | 0.087 | bioplex_WMM WMM_only |
| 84127 | TANK | 0.008 | 0.085 | bioplex_WMM WMM_only |
| OTUD4 | 84127 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| 84127 | TRAF2 | 0.008 | 0.049 | bioplex_WMM WMM_only |
| SNX29 | TANK | 0.008 | 0.04 | bioplex_WMM WMM_only |
| OTUD4 | SNX29 | 0.008 | 0.016 | bioplex_WMM youn_WMM WMM_only |
| SNX29 | TRAF2 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| OTUD4 | TANK | 0.007 | 0.008 | bioplex_WMM WMM_only |
| OTUD4 | TRAF2 | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05715 has an average edge precision of 0.205 which is ranked 6119 out of all 6965 complexes.
Related Complexes