hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05720
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| WNT4 | Protein Wnt-4 | UniProt NCBI |
| WNT7A | Protein Wnt-7a | UniProt NCBI |
| WNT7B | Protein Wnt-7b | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4150 | 3.85431460229e-07 | 1.0 | WNT7B WNT4 WNT7A | Wnt Signaling in Kidney Disease |
| REAC:R-HSA-3238698 | 7.96236129391e-07 | 1.0 | WNT7B WNT4 WNT7A | WNT ligand biogenesis and trafficking |
| KEGG:05217 | 8.33606267338e-07 | 1.0 | WNT7B WNT4 WNT7A | Basal cell carcinoma |
| KEGG:04916 | 3.41513932698e-06 | 1.0 | WNT7B WNT4 WNT7A | Melanogenesis |
| WP:WP4336 | 4.90008084364e-06 | 1.0 | WNT7B WNT4 WNT7A | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| WP:WP4258 | 6.82717373445e-06 | 1.0 | WNT7B WNT4 WNT7A | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| KEGG:04550 | 9.10053254791e-06 | 1.0 | WNT7B WNT4 WNT7A | Signaling pathways regulating pluripotency of stem cells |
| WP:WP399 | 9.49666017649e-06 | 1.0 | WNT7B WNT4 WNT7A | Wnt Signaling Pathway and Pluripotency |
| WP:WP3931 | 9.79655470838e-06 | 1.0 | WNT7B WNT4 WNT7A | ESC Pluripotency Pathways |
| KEGG:05224 | 1.07586932974e-05 | 1.0 | WNT7B WNT4 WNT7A | Breast cancer |
| KEGG:05226 | 1.10108501715e-05 | 1.0 | WNT7B WNT4 WNT7A | Gastric cancer |
| WP:WP710 | 1.17293801192e-05 | 1.0 | WNT7B WNT4 WNT7A | DNA Damage Response (only ATM dependent) |
| WP:WP428 | 1.27844858595e-05 | 1.0 | WNT7B WNT4 WNT7A | Wnt Signaling |
| KEGG:04934 | 1.37523983447e-05 | 1.0 | WNT7B WNT4 WNT7A | Cushing syndrome |
| KEGG:04390 | 1.40492126975e-05 | 1.0 | WNT7B WNT4 WNT7A | Hippo signaling pathway |
| KEGG:04150 | 1.46555920905e-05 | 1.0 | WNT7B WNT4 WNT7A | mTOR signaling pathway |
| KEGG:04310 | 1.55974889844e-05 | 1.0 | WNT7B WNT4 WNT7A | Wnt signaling pathway |
| REAC:R-HSA-373080 | 1.70037551742e-05 | 1.0 | WNT7B WNT4 WNT7A | Class B/2 (Secretin family receptors) |
| KEGG:05225 | 1.97683471245e-05 | 1.0 | WNT7B WNT4 WNT7A | Hepatocellular carcinoma |
| WP:WP4239 | 2.58282233279e-05 | 1.0 | WNT7B WNT4 WNT7A | Epithelial to mesenchymal transition in colorectal cancer |
| WP:WP4262 | 2.82110193573e-05 | 1.0 | WNT7B WNT4 WNT7A | Breast cancer pathway |
| KEGG:05205 | 3.27739581519e-05 | 1.0 | WNT7B WNT4 WNT7A | Proteoglycans in cancer |
| KEGG:05165 | 0.000150762444884 | 1.0 | WNT7B WNT4 WNT7A | Human papillomavirus infection |
| GO:0005109 | 0.000331851076788 | 1.0 | WNT7B WNT4 WNT7A | frizzled binding |
| KEGG:05200 | 0.000500689425538 | 1.0 | WNT7B WNT4 WNT7A | Pathways in cancer |
| REAC:R-HSA-500792 | 0.000674298253576 | 1.0 | WNT7B WNT4 WNT7A | GPCR ligand binding |
| HP:0000151 | 0.000803978270478 | 0.666666666667 | WNT4 WNT7A | Aplasia of the uterus |
| REAC:R-HSA-195721 | 0.00221076692273 | 1.0 | WNT7B WNT4 WNT7A | Signaling by WNT |
| GO:0005796 | 0.00690911398953 | 1.0 | WNT7B WNT4 WNT7A | Golgi lumen |
| HP:0008684 | 0.00913104209388 | 0.666666666667 | WNT4 WNT7A | Aplasia/hypoplasia of the uterus |
| HP:0100625 | 0.0103735850487 | 0.666666666667 | WNT4 WNT7A | Enlarged thorax |
| REAC:R-HSA-372790 | 0.0148482904699 | 1.0 | WNT7B WNT4 WNT7A | Signaling by GPCR |
| GO:0030666 | 0.0212638981157 | 1.0 | WNT7B WNT4 WNT7A | endocytic vesicle membrane |
| GO:0045165 | 0.022423560513 | 1.0 | WNT7B WNT4 WNT7A | cell fate commitment |
| GO:0070307 | 0.0378589948753 | 0.666666666667 | WNT7A WNT7B | lens fiber cell development |
| GO:0070306 | 0.0486736709081 | 0.666666666667 | WNT7A WNT7B | lens fiber cell differentiation |
| GO:0001664 | 0.0490669153423 | 1.0 | WNT7B WNT4 WNT7A | G protein-coupled receptor binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WNT4 | WNT7B | 0.998 | 0.941 | bioplex (WNT4) bioplex_WMM |
| WNT7A | WNT7B | 0.449 | 0.593 | bioplex (WNT7A) bioplex_WMM |
Images
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Complex HuMAP2_05720 has an average edge precision of 0.767 which is ranked 1062 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| WNT4 | HuMAP2_02896 HuMAP2_03376 HuMAP2_05188 HuMAP2_05720 |
| WNT7A | HuMAP2_02896 HuMAP2_03376 HuMAP2_04106 HuMAP2_05720 |
| WNT7B | HuMAP2_02896 HuMAP2_03376 HuMAP2_05188 HuMAP2_05720 |