hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05731
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RBM10 | RNA-binding protein 10 (G patch domain-containing protein 9) (RNA-binding motif protein 10) (RNA-binding protein S1-1) (S1-1) | UniProt NCBI |
| CDC5L | Cell division cycle 5-like protein (Cdc5-like protein) (Pombe cdc5-related protein) | UniProt NCBI |
| MEA1 | Male-enhanced antigen 1 (MEA-1) | UniProt NCBI |
| MSH6 | DNA mismatch repair protein Msh6 (hMSH6) (G/T mismatch-binding protein) (GTBP) (GTMBP) (MutS protein homolog 6) (MutS-alpha 160 kDa subunit) (p160) | UniProt NCBI |
| MSH2 | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | UniProt NCBI |
| RSRC2 | Arginine/serine-rich coiled-coil protein 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2740 | 8.39001385941e-06 | 0.333333333333 | MSH6 MSH2 | MSH2-MSH6 complex |
| CORUM:1078 | 8.39001385941e-06 | 0.333333333333 | MSH6 MSH2 | MSH2-MSH6 complex |
| CORUM:374 | 8.39001385941e-06 | 0.333333333333 | MSH6 MSH2 | MSH2-MSH6 complex |
| REAC:R-HSA-5632968 | 2.21716431826e-05 | 0.333333333333 | MSH6 MSH2 | Defective Mismatch Repair Associated With MSH6 |
| CORUM:2226 | 2.51655344529e-05 | 0.333333333333 | MSH6 MSH2 | MutS-alpha-PK-zeta complex |
| CORUM:377 | 2.51655344529e-05 | 0.333333333333 | MSH6 MSH2 | PCNA-MSH2-MSH6 complex |
| CORUM:286 | 2.51655344529e-05 | 0.333333333333 | MSH6 MSH2 | PCNA-MSH2-MSH6 complex |
| CORUM:289 | 2.51655344529e-05 | 0.333333333333 | MSH6 MSH2 | PCNA-MSH2-MSH6 complex |
| CORUM:431 | 5.0322056017e-05 | 0.333333333333 | MSH6 MSH2 | MSH2-MSH6-PMS2-MLH1 complex |
| CORUM:370 | 5.0322056017e-05 | 0.333333333333 | MSH6 MSH2 | MSH2-MSH6-PMS1-MLH1 complex |
| CORUM:369 | 5.0322056017e-05 | 0.333333333333 | MSH6 MSH2 | MSH2-MSH6-PMS2-MLH1 complex |
| REAC:R-HSA-5632928 | 6.65030189148e-05 | 0.333333333333 | MSH6 MSH2 | Defective Mismatch Repair Associated With MSH2 |
| CORUM:376 | 8.38550741504e-05 | 0.333333333333 | MSH6 MSH2 | PCNA-MutS-alpha-MutL-alpha-DNA complex |
| CORUM:2224 | 8.38550741504e-05 | 0.333333333333 | MSH6 MSH2 | MSH2/6-BLM-p53-RAD51 complex |
| WP:WP531 | 0.000200941842998 | 0.333333333333 | MSH6 MSH2 | DNA Mismatch Repair |
| REAC:R-HSA-5423599 | 0.000221597343492 | 0.333333333333 | MSH6 MSH2 | Diseases of Mismatch Repair (MMR) |
| HP:0006758 | 0.000225371341878 | 0.333333333333 | MSH6 MSH2 | Malignant genitourinary tract tumor |
| HP:0100684 | 0.000225371341878 | 0.333333333333 | MSH6 MSH2 | Salivary gland neoplasm |
| CORUM:434 | 0.000234668084372 | 0.333333333333 | MSH6 MSH2 | BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) |
| CORUM:438 | 0.000377010054596 | 0.333333333333 | MSH6 MSH2 | GCN5-TRRAP histone acetyltransferase complex |
| HP:0012118 | 0.00045066196833 | 0.333333333333 | MSH6 MSH2 | Laryngeal carcinoma |
| HP:0100605 | 0.00045066196833 | 0.333333333333 | MSH6 MSH2 | Neoplasm of the larynx |
| CORUM:433 | 0.000552750021156 | 0.333333333333 | MSH6 MSH2 | BASC complex (BRCA1-associated genome surveillance complex) |
| HP:0000997 | 0.00112625143517 | 0.333333333333 | MSH6 MSH2 | Axillary freckling |
| CORUM:1335 | 0.00113798027977 | 0.333333333333 | CDC5L MSH2 | SNW1 complex |
| KEGG:03430 | 0.00157819534506 | 0.333333333333 | MSH6 MSH2 | Mismatch repair |
| REAC:R-HSA-5358565 | 0.00201328766088 | 0.333333333333 | MSH6 MSH2 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-5358508 | 0.00232260810736 | 0.333333333333 | MSH6 MSH2 | Mismatch Repair |
| WP:WP1971 | 0.0050096749716 | 0.333333333333 | MSH6 MSH2 | Integrated Cancer Pathway |
| GO:0032143 | 0.00676235117068 | 0.333333333333 | MSH6 MSH2 | single thymine insertion binding |
| GO:0032301 | 0.00676235117068 | 0.333333333333 | MSH6 MSH2 | MutSalpha complex |
| GO:0032137 | 0.00676235117068 | 0.333333333333 | MSH6 MSH2 | guanine/thymine mispair binding |
| HP:0002888 | 0.00682280818411 | 0.333333333333 | MSH6 MSH2 | Ependymoma |
| HP:0010286 | 0.00682280818411 | 0.333333333333 | MSH6 MSH2 | Abnormal salivary gland morphology |
| HP:0100571 | 0.00682280818411 | 0.333333333333 | MSH6 MSH2 | Cardiac diverticulum |
| HP:0002885 | 0.00787106080828 | 0.333333333333 | MSH6 MSH2 | Medulloblastoma |
| HP:0012114 | 0.0101912456166 | 0.333333333333 | MSH6 MSH2 | Endometrial carcinoma |
| HP:0009592 | 0.0114630974264 | 0.333333333333 | MSH6 MSH2 | Astrocytoma |
| HP:0009720 | 0.0114630974264 | 0.333333333333 | MSH6 MSH2 | Adenoma sebaceum |
| HP:0100707 | 0.0128094019441 | 0.333333333333 | MSH6 MSH2 | Abnormality of the astrocytes |
| HP:0012174 | 0.0128094019441 | 0.333333333333 | MSH6 MSH2 | Glioblastoma multiforme |
| HP:0030126 | 0.0128094019441 | 0.333333333333 | MSH6 MSH2 | Abnormality of the endometrium |
| WP:WP4216 | 0.0137172539953 | 0.333333333333 | MSH6 MSH2 | Chromosomal and microsatellite instability in colorectal cancer |
| HP:0002859 | 0.0142301190129 | 0.333333333333 | MSH6 MSH2 | Rhabdomyosarcoma |
| KEGG:01524 | 0.015804666162 | 0.333333333333 | MSH6 MSH2 | Platinum drug resistance |
| HP:0010615 | 0.0172946302375 | 0.333333333333 | MSH6 MSH2 | Angiofibromas |
| GO:0032142 | 0.020283420769 | 0.333333333333 | MSH6 MSH2 | single guanine insertion binding |
| KEGG:05210 | 0.0204981178463 | 0.333333333333 | MSH6 MSH2 | Colorectal cancer |
| HP:0006725 | 0.0224484879882 | 0.333333333333 | MSH6 MSH2 | Pancreatic adenocarcinoma |
| HP:0009728 | 0.0224484879882 | 0.333333333333 | MSH6 MSH2 | Neoplasm of striated muscle |
| HP:0010524 | 0.0262553193116 | 0.333333333333 | MSH6 MSH2 | Agnosia |
| HP:0002893 | 0.0262553193116 | 0.333333333333 | MSH6 MSH2 | Pituitary adenoma |
| HP:0002672 | 0.034757762481 | 0.333333333333 | MSH6 MSH2 | Gastrointestinal carcinoma |
| HP:0006749 | 0.034757762481 | 0.333333333333 | MSH6 MSH2 | Malignant gastrointestinal tract tumors |
| HP:0100576 | 0.0370683023611 | 0.333333333333 | MSH6 MSH2 | Amaurosis fugax |
| HP:0100743 | 0.0394527338604 | 0.333333333333 | MSH6 MSH2 | Neoplasm of the rectum |
| HP:0040277 | 0.0394527338604 | 0.333333333333 | MSH6 MSH2 | Neoplasm of the pituitary gland |
| HP:0011750 | 0.0394527338604 | 0.333333333333 | MSH6 MSH2 | Neoplasm of the anterior pituitary |
| GO:0032138 | 0.0405595771497 | 0.333333333333 | MSH6 MSH2 | single base insertion or deletion binding |
| HP:0009733 | 0.0419110169922 | 0.333333333333 | MSH6 MSH2 | Glioma |
| HPA:008020_03 | 0.0459470526365 | 0.5 | RSRC2 CDC5L MSH2 | cerebral cortex; glial cells[Uncertain,High] |
| HP:0100613 | 0.0470489782673 | 0.333333333333 | MSH6 MSH2 | Death in early adulthood |
| HP:0003006 | 0.0470489782673 | 0.333333333333 | MSH6 MSH2 | Neuroblastoma |
| HP:0004376 | 0.0470489782673 | 0.333333333333 | MSH6 MSH2 | Neuroblastic tumor |
| HP:0030067 | 0.0470489782673 | 0.333333333333 | MSH6 MSH2 | Peripheral primitive neuroectodermal neoplasm |
| HP:0003003 | 0.0497285764978 | 0.333333333333 | MSH6 MSH2 | Colon cancer |
| HP:0010526 | 0.0497285764978 | 0.333333333333 | MSH6 MSH2 | Dysgraphia |
| CORUM:375 | 0.0499726005494 | 0.166666666667 | MSH2 | MSH2-MSH3 complex |
| CORUM:378 | 0.0499726005494 | 0.166666666667 | MSH2 | MSH2-MSH3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MSH6 | MSH2 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM hein (MSH6) Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| RSRC2 | CDC5L | 0.048 | 0.294 | youn (CDC5L) youn_WMM fraction |
| RBM10 | CDC5L | 0.045 | 0.287 | youn (CDC5L) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| MSH6 | CDC5L | 0.031 | 0.239 | youn (CDC5L) bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| MSH2 | CDC5L | 0.023 | 0.21 | youn (CDC5L) youn_WMM gupta_WMM fraction treiber_WMM |
| MSH6 | MEA1 | 0.022 | 0.205 | bioplex_WMM fraction |
| RBM10 | MSH2 | 0.008 | 0.037 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| MSH6 | RBM10 | 0.008 | 0.026 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
| RBM10 | RSRC2 | 0.007 | 0.005 | youn_WMM WMM_only |
| RSRC2 | MSH2 | 0.007 | 0.01 | youn_WMM WMM_only |
| MSH6 | RSRC2 | 0.007 | 0.007 | youn_WMM WMM_only |
| MEA1 | MSH2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| MEA1 | RBM10 | 0.007 | 0.002 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05731 has an average edge precision of 0.175 which is ranked 6478 out of all 6965 complexes.
Related Complexes