hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05732
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CIAO2B | Cytosolic iron-sulfur assembly component 2B (MSS19-interacting protein of 18 kDa) (Mitotic spindle-associated MMXD complex subunit MIP18) (Protein FAM96B) | UniProt NCBI |
| CIAO1 | Probable cytosolic iron-sulfur protein assembly protein CIAO1 (WD repeat-containing protein 39) | UniProt NCBI |
| CIAO2A | Cytosolic iron-sulfur assembly component 2A (MIP18 family protein FAM96A) | UniProt NCBI |
| MMS19 | MMS19 nucleotide excision repair protein homolog (hMMS19) (MET18 homolog) (MMS19-like protein) | UniProt NCBI |
| CDKAL1 | Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0097361 | 6.09856266088e-10 | 0.8 | CIAO2B CIAO2A MMS19 CIAO1 | CIA complex |
| CORUM:5495 | 1.35146690511e-09 | 0.6 | CIAO2B MMS19 CIAO1 | CIA targeting (MIP18, CIAO1, MMS19) complex |
| CORUM:6897 | 1.35146690511e-09 | 0.6 | CIAO2B MMS19 CIAO1 | CIA2B-CIA1-MMS19 complex |
| CORUM:6896 | 5.40532307664e-09 | 0.6 | CIAO2B MMS19 CIAO1 | MMS19 complex |
| CORUM:6895 | 1.35119464053e-08 | 0.6 | CIAO2B MMS19 CIAO1 | MMXD complex |
| GO:0097428 | 8.71719597884e-08 | 0.8 | CIAO2B CIAO2A MMS19 CIAO1 | protein maturation by iron-sulfur cluster transfer |
| GO:0016226 | 7.29370383293e-07 | 0.8 | CIAO2B CIAO2A MMS19 CIAO1 | iron-sulfur cluster assembly |
| GO:0031163 | 7.29370383293e-07 | 0.8 | CIAO2B CIAO2A MMS19 CIAO1 | metallo-sulfur cluster assembly |
| REAC:R-HSA-2564830 | 7.76884875116e-07 | 0.6 | CIAO2B MMS19 CIAO1 | Cytosolic iron-sulfur cluster assembly |
| CORUM:7223 | 6.70868171695e-06 | 0.4 | CIAO2B MMS19 | MMS19-FAM96B complex |
| GO:0071817 | 9.08002798436e-06 | 0.6 | CIAO2B MMS19 CIAO1 | MMXD complex |
| GO:0051188 | 0.0049971900723 | 0.8 | CIAO2B CIAO2A MMS19 CIAO1 | cofactor biosynthetic process |
| GO:0044445 | 0.00796512695553 | 0.8 | CIAO2B CIAO2A MMS19 CIAO1 | cytosolic part |
| GO:0051604 | 0.0086215524743 | 0.8 | CIAO2B CIAO2A MMS19 CIAO1 | protein maturation |
| GO:0006790 | 0.0376297096835 | 0.8 | CIAO2B CIAO2A MMS19 CIAO1 | sulfur compound metabolic process |
| CORUM:7222 | 0.0499494897235 | 0.2 | MMS19 | MMS19-XPD complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CIAO2B | MMS19 | 1.0 | 0.949 | hein_WMM bioplex (MMS19) bioplex_WMM boldt youn_WMM hein (MMS19) boldt_WMM |
| MMS19 | CIAO1 | 1.0 | 0.949 | hein_WMM bioplex (MMS19) bioplex_WMM boldt youn_WMM hein (MMS19) fraction boldt_WMM |
| MMS19 | CDKAL1 | 0.362 | 0.544 | hein_WMM bioplex (CDKAL1,MMS19) bioplex_WMM boldt youn_WMM hein (MMS19) boldt_WMM |
| CIAO1 | CIAO2A | 0.051 | 0.294 | Guru fraction treiber_WMM |
| CIAO2B | CDKAL1 | 0.03 | 0.231 | hein_WMM bioplex (CDKAL1) bioplex_WMM boldt boldt_WMM |
| CIAO1 | CDKAL1 | 0.029 | 0.232 | hein_WMM bioplex (CDKAL1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| CIAO2B | CIAO1 | 0.021 | 0.185 | hein_WMM bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_05732 has an average edge precision of 0.483 which is ranked 2602 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CIAO2B | HuMAP2_00354 HuMAP2_05732 |
| CIAO1 | HuMAP2_00354 HuMAP2_05732 |
| CIAO2A | HuMAP2_05732 |
| MMS19 | HuMAP2_00354 HuMAP2_05732 |
| CDKAL1 | HuMAP2_00907 HuMAP2_05732 HuMAP2_06362 |