hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05733
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | UniProt NCBI |
| LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | UniProt NCBI |
| POLB | DNA polymerase beta (EC 2.7.7.7) (EC 4.2.99.-) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:362 | 9.0142507219e-10 | 1.0 | XRCC1 POLB LIG3 | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
| CORUM:1086 | 9.0142507219e-10 | 1.0 | XRCC1 POLB LIG3 | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-110381 | 1.79838764402e-09 | 1.0 | XRCC1 POLB LIG3 | Resolution of AP sites via the single-nucleotide replacement pathway |
| CORUM:1085 | 2.25356268047e-09 | 1.0 | XRCC1 POLB LIG3 | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
| REAC:R-HSA-5649702 | 8.99193822011e-09 | 1.0 | XRCC1 POLB LIG3 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| GO:0006288 | 9.08185760231e-08 | 1.0 | XRCC1 POLB LIG3 | base-excision repair, DNA ligation |
| KEGG:03410 | 1.49158985786e-07 | 1.0 | XRCC1 POLB LIG3 | Base excision repair |
| REAC:R-HSA-73933 | 2.94261178253e-06 | 1.0 | XRCC1 POLB LIG3 | Resolution of Abasic Sites (AP sites) |
| CORUM:363 | 3.35600554376e-06 | 0.666666666667 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:212 | 3.35600554376e-06 | 0.666666666667 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| CORUM:365 | 3.35600554376e-06 | 0.666666666667 | XRCC1 LIG3 | DNA ligase III-XRCC1 complex |
| GO:0051103 | 5.08584025729e-06 | 1.0 | XRCC1 POLB LIG3 | DNA ligation involved in DNA repair |
| CORUM:5243 | 2.01342304124e-05 | 0.666666666667 | XRCC1 LIG3 | XRCC1-LIG3-PNK-TDP1 complex |
| REAC:R-HSA-73884 | 4.7655024582e-05 | 1.0 | XRCC1 POLB LIG3 | Base Excision Repair |
| GO:0006266 | 5.08584025729e-05 | 1.0 | XRCC1 POLB LIG3 | DNA ligation |
| REAC:R-HSA-5685939 | 0.000301184970683 | 0.666666666667 | XRCC1 LIG3 | HDR through MMEJ (alt-NHEJ) |
| GO:0006284 | 0.000766145507331 | 1.0 | XRCC1 POLB LIG3 | base-excision repair |
| REAC:R-HSA-5696397 | 0.00200655101382 | 0.666666666667 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-73894 | 0.00245537461814 | 1.0 | XRCC1 POLB LIG3 | DNA Repair |
| REAC:R-HSA-6782210 | 0.0134604567412 | 0.666666666667 | XRCC1 LIG3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6781827 | 0.0200378707185 | 0.666666666667 | XRCC1 LIG3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696399 | 0.0232544758505 | 0.666666666667 | XRCC1 LIG3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-5696398 | 0.0399448421955 | 0.666666666667 | XRCC1 LIG3 | Nucleotide Excision Repair |
| CORUM:213 | 0.0499776345577 | 0.333333333333 | XRCC1 | DNA ligase IV-XRCC1 complex |
| CORUM:7352 | 0.0499776345577 | 0.333333333333 | LIG3 | PARP1-LIG3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC1 | POLB | 1.0 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM hein (XRCC1) |
| POLB | LIG3 | 0.999 | 0.949 | hein_WMM bioplex (POLB) bioplex_WMM |
| XRCC1 | LIG3 | 0.186 | 0.441 | hein_WMM bioplex_WMM youn_WMM hein (XRCC1) gupta_WMM |
Images
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Complex HuMAP2_05733 has an average edge precision of 0.78 which is ranked 1003 out of all 6965 complexes.
Related Complexes