hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05757
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ITGB1 | Integrin beta-1 (Fibronectin receptor subunit beta) (Glycoprotein IIa) (GPIIA) (VLA-4 subunit beta) (CD antigen CD29) | UniProt NCBI |
| ITGAV | Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2436 | 1.67592346237e-06 | 1.0 | ITGB1 ITGAV | ITGAV-ITGB1 complex |
| CORUM:2885 | 5.02777038712e-06 | 1.0 | ITGB1 ITGAV | ITGAV-ITGB1-SPP1 complex |
| REAC:R-HSA-445144 | 0.000318425457851 | 1.0 | ITGB1 ITGAV | Signal transduction by L1 |
| KEGG:05412 | 0.00037291412281 | 1.0 | ITGB1 ITGAV | Arrhythmogenic right ventricular cardiomyopathy (ARVC) |
| KEGG:04512 | 0.000438130325039 | 1.0 | ITGB1 ITGAV | ECM-receptor interaction |
| KEGG:05410 | 0.000472708042999 | 1.0 | ITGB1 ITGAV | Hypertrophic cardiomyopathy (HCM) |
| KEGG:05414 | 0.000520854232564 | 1.0 | ITGB1 ITGAV | Dilated cardiomyopathy (DCM) |
| REAC:R-HSA-3000170 | 0.000544675125272 | 1.0 | ITGB1 ITGAV | Syndecan interactions |
| KEGG:05222 | 0.000610727119751 | 1.0 | ITGB1 ITGAV | Small cell lung cancer |
| WP:WP2572 | 0.000727651340845 | 1.0 | ITGB1 ITGAV | Primary Focal Segmental Glomerulosclerosis FSGS |
| REAC:R-HSA-3000157 | 0.000729026706133 | 1.0 | ITGB1 ITGAV | Laminin interactions |
| REAC:R-HSA-2129379 | 0.000729026706133 | 1.0 | ITGB1 ITGAV | Molecules associated with elastic fibres |
| KEGG:04514 | 0.000736782597884 | 1.0 | ITGB1 ITGAV | Cell adhesion molecules (CAMs) |
| WP:WP2118 | 0.00087407580421 | 1.0 | ITGB1 ITGAV | Arrhythmogenic Right Ventricular Cardiomyopathy |
| REAC:R-HSA-1566948 | 0.00111616502594 | 1.0 | ITGB1 ITGAV | Elastic fibre formation |
| KEGG:04145 | 0.00131964328671 | 1.0 | ITGB1 ITGAV | Phagosome |
| WP:WP185 | 0.00159390293709 | 1.0 | ITGB1 ITGAV | Integrin-mediated Cell Adhesion |
| WP:WP4658 | 0.00166357564612 | 1.0 | ITGB1 ITGAV | Small cell lung cancer |
| WP:WP4541 | 0.00191916643968 | 1.0 | ITGB1 ITGAV | Hippo-Merlin Signaling Dysregulation |
| KEGG:04810 | 0.00253730419006 | 1.0 | ITGB1 ITGAV | Regulation of actin cytoskeleton |
| KEGG:05205 | 0.00256458703081 | 1.0 | ITGB1 ITGAV | Proteoglycans in cancer |
| WP:WP4217 | 0.00257192893285 | 1.0 | ITGB1 ITGAV | Ebola Virus Pathway on Host |
| KEGG:04510 | 0.00259201576911 | 1.0 | ITGB1 ITGAV | Focal adhesion |
| REAC:R-HSA-3000171 | 0.00267477384595 | 1.0 | ITGB1 ITGAV | Non-integrin membrane-ECM interactions |
| GO:0019960 | 0.00270494046827 | 1.0 | ITGB1 ITGAV | C-X3-C chemokine binding |
| REAC:R-HSA-3000178 | 0.00359485582679 | 1.0 | ITGB1 ITGAV | ECM proteoglycans |
| REAC:R-HSA-216083 | 0.00465068760809 | 1.0 | ITGB1 ITGAV | Integrin cell surface interactions |
| KEGG:04151 | 0.00654350485448 | 1.0 | ITGB1 ITGAV | PI3K-Akt signaling pathway |
| WP:WP306 | 0.00654923464894 | 1.0 | ITGB1 ITGAV | Focal Adhesion |
| KEGG:05165 | 0.00707836525128 | 1.0 | ITGB1 ITGAV | Human papillomavirus infection |
| REAC:R-HSA-202733 | 0.00863268175469 | 1.0 | ITGB1 ITGAV | Cell surface interactions at the vascular wall |
| WP:WP3888 | 0.00889388896944 | 1.0 | ITGB1 ITGAV | VEGFA-VEGFR2 Signaling Pathway |
| REAC:R-HSA-373760 | 0.0102315127378 | 1.0 | ITGB1 ITGAV | L1CAM interactions |
| WP:WP3932 | 0.0121610546673 | 1.0 | ITGB1 ITGAV | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| WP:WP4172 | 0.015291110435 | 1.0 | ITGB1 ITGAV | PI3K-Akt Signaling Pathway |
| KEGG:05200 | 0.0157394270613 | 1.0 | ITGB1 ITGAV | Pathways in cancer |
| CORUM:2354 | 0.0249595281251 | 0.5 | ITGAV | ITGAV-ITGB6 complex |
| CORUM:3057 | 0.0249595281251 | 0.5 | ITGB1 | ITGA10-ITGB1 complex |
| CORUM:3035 | 0.0249595281251 | 0.5 | ITGB1 | LAT2-ITGB1 complex |
| CORUM:7012 | 0.0499173803268 | 0.5 | ITGB1 | ITGB1-RACK1 complex |
| CORUM:3110 | 0.0499173803268 | 0.5 | ITGAV | ITGAV-P2RY2-GNA12 complex |
| CORUM:3104 | 0.0499173803268 | 0.5 | ITGB1 | ITGB1-NRP1 complex |
| CORUM:3058 | 0.0499173803268 | 0.5 | ITGB1 | ITGA11-ITGB1 complex |
| CORUM:2352 | 0.0499173803268 | 0.5 | ITGAV | ITGAV-ITGB6-SPP1 complex |
| CORUM:2816 | 0.0499173803268 | 0.5 | ITGAV | ITGAV-ITGB3 complex |
| CORUM:2444 | 0.0499173803268 | 0.5 | ITGB1 | ITGB1-ITGA9 complex |
| CORUM:2439 | 0.0499173803268 | 0.5 | ITGB1 | ITGA8-ITGB1 complex |
| CORUM:2432 | 0.0499173803268 | 0.5 | ITGB1 | ITGA2-ITGB1 complex |
| CORUM:2420 | 0.0499173803268 | 0.5 | ITGB1 | ITGA4-ITGB1-CD53 complex |
| CORUM:2418 | 0.0499173803268 | 0.5 | ITGB1 | ITGA4-ITGB1 complex |
| CORUM:2413 | 0.0499173803268 | 0.5 | ITGB1 | ITGA6-ITGB1 complex |
| CORUM:2406 | 0.0499173803268 | 0.5 | ITGB1 | ITGA3-ITGB1 complex |
| CORUM:2397 | 0.0499173803268 | 0.5 | ITGB1 | ITGA7-ITGB1-ITGB1BP3 complex |
| CORUM:2390 | 0.0499173803268 | 0.5 | ITGB1 | CD98-LAT2-ITGB1 complex |
| CORUM:2385 | 0.0499173803268 | 0.5 | ITGB1 | ITGA5-ITGB4 complex |
| CORUM:2353 | 0.0499173803268 | 0.5 | ITGAV | ITGAV-ITGB6-TGFB3 complex |
| CORUM:2350 | 0.0499173803268 | 0.5 | ITGAV | ITGAV-ITGB5 complex |
| CORUM:2364 | 0.0499173803268 | 0.5 | ITGAV | ITGAV-ITGB3-ADAM23 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ITGB1 | ITGAV | 0.804 | 0.768 | hein_WMM bioplex_WMM youn_WMM hein (ITGB1) fraction |
Images
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Complex HuMAP2_05757 has an average edge precision of 0.768 which is ranked 1054 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ITGB1 | HuMAP2_04065 HuMAP2_05757 |
| ITGAV | HuMAP2_04065 HuMAP2_05757 |