hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05767
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GNG3 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 | UniProt NCBI |
| GNAQ | Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q) | UniProt NCBI |
| GNA13 | Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13) (G-protein subunit alpha-13) | UniProt NCBI |
| MTHFR | Methylenetetrahydrofolate reductase (EC 1.5.1.20) | UniProt NCBI |
| GNAZ | Guanine nucleotide-binding protein G(z) subunit alpha (G(x) alpha chain) (Gz-alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP35 | 2.00221502161e-07 | 0.8 | GNA13 GNAQ GNG3 GNAZ | G Protein Signaling Pathways |
| GO:0005834 | 1.82141275099e-06 | 0.8 | GNA13 GNAQ GNG3 GNAZ | heterotrimeric G-protein complex |
| GO:1905360 | 1.82141275099e-06 | 0.8 | GNA13 GNAQ GNG3 GNAZ | GTPase complex |
| REAC:R-HSA-428930 | 3.60987410111e-06 | 0.6 | GNA13 GNG3 GNAQ | Thromboxane signalling through TP receptor |
| REAC:R-HSA-456926 | 8.88541585136e-06 | 0.6 | GNA13 GNG3 GNAQ | Thrombin signalling through proteinase activated receptors (PARs) |
| REAC:R-HSA-392518 | 9.90965664735e-06 | 0.6 | GNA13 GNG3 GNAQ | Signal amplification |
| KEGG:04730 | 2.01601392523e-05 | 0.6 | GNA13 GNAZ GNAQ | Long-term depression |
| GO:0031234 | 0.000164422098058 | 0.8 | GNA13 GNAQ GNG3 GNAZ | extrinsic component of cytoplasmic side of plasma membrane |
| WP:WP536 | 0.000186709829938 | 0.6 | GNAQ GNG3 GNAZ | Calcium Regulation in the Cardiac Cell |
| KEGG:04371 | 0.000264979384683 | 0.6 | GNA13 GNG3 GNAQ | Apelin signaling pathway |
| GO:0031683 | 0.000507918241599 | 0.6 | GNA13 GNAZ GNAQ | G-protein beta/gamma-subunit complex binding |
| GO:0019897 | 0.00113692677057 | 0.8 | GNA13 GNAQ GNG3 GNAZ | extrinsic component of plasma membrane |
| KEGG:05163 | 0.00114726739179 | 0.6 | GNA13 GNG3 GNAQ | Human cytomegalovirus infection |
| REAC:R-HSA-388396 | 0.00122449193088 | 0.8 | GNA13 GNAQ GNG3 GNAZ | GPCR downstream signalling |
| GO:0009898 | 0.001292590007 | 0.8 | GNA13 GNAQ GNG3 GNAZ | cytoplasmic side of plasma membrane |
| REAC:R-HSA-372790 | 0.0016972853423 | 0.8 | GNA13 GNAQ GNG3 GNAZ | Signaling by GPCR |
| GO:0098562 | 0.0023227175406 | 0.8 | GNA13 GNAQ GNG3 GNAZ | cytoplasmic side of membrane |
| REAC:R-HSA-418592 | 0.0031096034254 | 0.4 | GNG3 GNAQ | ADP signalling through P2Y purinoceptor 1 |
| REAC:R-HSA-202040 | 0.00437263170532 | 0.4 | GNG3 GNAZ | G-protein activation |
| REAC:R-HSA-76002 | 0.00484900153486 | 0.6 | GNA13 GNG3 GNAQ | Platelet activation, signaling and aggregation |
| WP:WP2032 | 0.00688743357746 | 0.4 | GNA13 GNAQ | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| REAC:R-HSA-6814122 | 0.00995219083388 | 0.4 | GNG3 GNAZ | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| WP:WP2355 | 0.0115135837289 | 0.4 | GNAZ GNAQ | Corticotropin-releasing hormone signaling pathway |
| GO:0019898 | 0.0116598248695 | 0.8 | GNA13 GNAQ GNG3 GNAZ | extrinsic component of membrane |
| REAC:R-HSA-418597 | 0.0126969553517 | 0.4 | GNG3 GNAZ | G alpha (z) signalling events |
| KEGG:05200 | 0.0137388951306 | 0.6 | GNA13 GNG3 GNAQ | Pathways in cancer |
| KEGG:04713 | 0.0162467151192 | 0.4 | GNG3 GNAQ | Circadian entrainment |
| GO:0003924 | 0.0179259894308 | 0.8 | GNA13 GNAQ GNG3 GNAZ | GTPase activity |
| KEGG:04726 | 0.0189323955438 | 0.4 | GNG3 GNAQ | Serotonergic synapse |
| KEGG:04725 | 0.0193326076279 | 0.4 | GNG3 GNAQ | Cholinergic synapse |
| KEGG:04928 | 0.0197369504817 | 0.4 | GNA13 GNAQ | Parathyroid hormone synthesis, secretion and action |
| KEGG:04270 | 0.0205580217111 | 0.4 | GNA13 GNAQ | Vascular smooth muscle contraction |
| KEGG:04724 | 0.020974746694 | 0.4 | GNG3 GNAQ | Glutamatergic synapse |
| WP:WP2889 | 0.0248637459957 | 0.2 | GNAQ | Oxytocin signaling |
| KEGG:04071 | 0.0249106474345 | 0.4 | GNA13 GNAQ | Sphingolipid signaling pathway |
| KEGG:04611 | 0.0258305316126 | 0.4 | GNA13 GNAQ | Platelet activation |
| WP:WP289 | 0.0279458043607 | 0.4 | GNG3 GNAQ | Myometrial Relaxation and Contraction Pathways |
| KEGG:04728 | 0.030676003082 | 0.4 | GNG3 GNAQ | Dopaminergic synapse |
| HP:0002204 | 0.0308081945037 | 0.4 | MTHFR GNAQ | Pulmonary embolism |
| REAC:R-HSA-422356 | 0.0313816354582 | 0.4 | GNG3 GNAQ | Regulation of insulin secretion |
| REAC:R-HSA-416482 | 0.0351349281697 | 0.4 | GNA13 GNG3 | G alpha (12/13) signalling events |
| KEGG:04723 | 0.0364781730982 | 0.4 | GNG3 GNAQ | Retrograde endocannabinoid signaling |
| WP:WP1495 | 0.0372906105173 | 0.2 | MTHFR | Glycine Metabolism |
| KEGG:04022 | 0.0415917953149 | 0.4 | GNA13 GNAQ | cGMP-PKG signaling pathway |
| GO:0098552 | 0.0464577202339 | 0.8 | GNA13 GNAQ GNG3 GNAZ | side of membrane |
| REAC:R-HSA-111885 | 0.0487798927038 | 0.4 | GNG3 GNAZ | Opioid Signalling |
| WP:WP733 | 0.0497141369515 | 0.2 | GNAQ | Serotonin Receptor 2 and STAT3 Signaling |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GNG3 | GNAQ | 0.251 | 0.474 | bioplex (GNG3) bioplex_WMM |
| GNG3 | GNA13 | 0.165 | 0.421 | bioplex (GNG3) bioplex_WMM |
| GNAZ | GNG3 | 0.086 | 0.352 | bioplex (GNG3) bioplex_WMM |
| MTHFR | GNAZ | 0.046 | 0.293 | bioplex (GNAZ) bioplex_WMM |
| GNAZ | GNAQ | 0.014 | 0.143 | bioplex_WMM WMM_only |
| MTHFR | GNAQ | 0.007 | 0.003 | bioplex_WMM WMM_only |
| GNAZ | GNA13 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| MTHFR | GNA13 | 0.006 | 0.006 | bioplex_WMM WMM_only |
| GNA13 | GNAQ | 0.006 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05767 has an average edge precision of 0.189 which is ranked 6325 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GNG3 | HuMAP2_03496 HuMAP2_05767 HuMAP2_06727 |
| GNAQ | HuMAP2_03496 HuMAP2_05767 HuMAP2_06727 |
| GNA13 | HuMAP2_03496 HuMAP2_05767 HuMAP2_06727 |
| MTHFR | HuMAP2_00093 HuMAP2_05767 HuMAP2_06727 |
| GNAZ | HuMAP2_00093 HuMAP2_03496 HuMAP2_05767 HuMAP2_06727 |