hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05774

Confidence: Medium High

Genename	Protein Name	Links
TNFRSF10B	Tumor necrosis factor receptor superfamily member 10B (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD antigen CD262)	UniProt NCBI
IL37	Interleukin-37 (FIL1 zeta) (IL-1X) (Interleukin-1 family member 7) (IL-1F7) (Interleukin-1 homolog 4) (IL-1H) (IL-1H4) (Interleukin-1 zeta) (IL-1 zeta) (Interleukin-1-related protein) (IL-1RP1) (Interleukin-23) (IL-37)	UniProt NCBI
FAS	Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)	UniProt NCBI
TNFRSF10A	Tumor necrosis factor receptor superfamily member 10A (Death receptor 4) (TNF-related apoptosis-inducing ligand receptor 1) (TRAIL receptor 1) (TRAIL-R1) (CD antigen CD261)	UniProt NCBI
FADD	FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity) (Protein FADD)	UniProt NCBI
CASP8	Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-3371378	2.03006918199e-14	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Regulation by c-FLIP
REAC:R-HSA-69416	2.03006918199e-14	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Dimerization of procaspase-8
REAC:R-HSA-5218900	2.03006918199e-14	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	CASP8 activity is inhibited
REAC:R-HSA-140534	2.07310633174e-13	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Caspase activation via Death Receptors in the presence of ligand
REAC:R-HSA-5675482	7.03481530925e-13	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Regulation of necroptotic cell death
REAC:R-HSA-5213460	1.37975151879e-12	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	RIPK1-mediated regulated necrosis
REAC:R-HSA-5218859	1.37975151879e-12	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Regulated Necrosis
REAC:R-HSA-5357769	4.23975677772e-12	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Caspase activation via extrinsic apoptotic signalling pathway
REAC:R-HSA-75158	4.19788236367e-11	0.666666666667	TNFRSF10A FADD CASP8 TNFRSF10B	TRAIL signaling
WP:WP1772	1.03635102909e-09	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Apoptosis Modulation and Signaling
CORUM:5800	2.25356268047e-09	0.5	FADD CASP8 FAS	DISC complex (FAS, FADD, CASP8)
CORUM:5473	2.25356268047e-09	0.5	FADD CASP8 FAS	DISC complex (FAS, FADD, CASP8)
CORUM:5860	2.25356268047e-09	0.5	FADD CASP8 FAS	DISC complex (FAS, FADD, CASP8)
GO:1902042	4.82439758657e-09	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
CORUM:5799	9.01288868683e-09	0.5	FADD CASP8 FAS	DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced
CORUM:5859	9.01288868683e-09	0.5	FADD CASP8 FAS	FAS-FADD-CASP8-CASP10 complex
KEGG:04210	1.06019966074e-08	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Apoptosis
GO:0071260	1.8497597492e-08	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	cellular response to mechanical stimulus
KEGG:05164	2.49519698097e-08	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Influenza A
GO:0036462	2.56043303928e-08	0.666666666667	TNFRSF10A FADD CASP8 TNFRSF10B	TRAIL-activated apoptotic signaling pathway
GO:1902041	2.82455062118e-08	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	regulation of extrinsic apoptotic signaling pathway via death domain receptors
KEGG:04217	2.85564481682e-08	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Necroptosis
REAC:R-HSA-73887	3.90905948705e-08	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Death Receptor Signalling
REAC:R-HSA-75157	5.95351688467e-08	0.5	FADD CASP8 FAS	FasL/ CD95L signaling
KEGG:05130	6.16382908626e-08	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Pathogenic Escherichia coli infection
REAC:R-HSA-109581	1.7280486461e-07	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Apoptosis
REAC:R-HSA-5357801	1.88863196375e-07	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Programmed Cell Death
GO:0008625	2.05203849429e-07	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	extrinsic apoptotic signaling pathway via death domain receptors
WP:WP254	3.26731768958e-07	0.666666666667	FADD CASP8 TNFRSF10B FAS	Apoptosis
GO:2001237	4.0462306571e-07	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	negative regulation of extrinsic apoptotic signaling pathway
GO:0006919	5.10555594437e-07	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0009612	5.92717909488e-07	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	response to mechanical stimulus
REAC:R-HSA-6803211	7.13882356429e-07	0.5	TNFRSF10A FAS TNFRSF10B	TP53 Regulates Transcription of Death Receptors and Ligands
WP:WP384	1.22215075874e-06	0.5	FADD CASP8 FAS	Apoptosis Modulation by HSP70
WP:WP2507	1.45108459325e-06	0.5	FADD CASP8 FAS	Nanomaterial induced apoptosis
GO:2001236	2.27476470409e-06	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	regulation of extrinsic apoptotic signaling pathway
GO:0043280	3.32055089865e-06	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001056	6.85743334778e-06	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of cysteine-type endopeptidase activity
CORUM:5808	8.39001385941e-06	0.333333333333	FADD CASP8	DISC complex (CD95, FADD, CASP8)
KEGG:04060	8.7605482185e-06	0.666666666667	TNFRSF10A FAS IL37 TNFRSF10B	Cytokine-cytokine receptor interaction
KEGG:04061	1.19484609684e-05	0.5	TNFRSF10A TNFRSF10B IL37	Viral protein interaction with cytokine and cytokine receptor
GO:0010950	1.3434313138e-05	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of endopeptidase activity
GO:0097191	1.69168716566e-05	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	extrinsic apoptotic signaling pathway
WP:WP314	1.7131668569e-05	0.5	FADD CASP8 FAS	Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
GO:0010952	1.75615636049e-05	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of peptidase activity
GO:0031265	1.81582264982e-05	0.5	FADD CASP8 FAS	CD95 death-inducing signaling complex
GO:2001234	2.26451406257e-05	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	negative regulation of apoptotic signaling pathway
CORUM:5861	2.51655344529e-05	0.333333333333	FADD FAS	FAS-FADD-CASP10 complex
CORUM:5798	2.51655344529e-05	0.333333333333	FADD CASP8	Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced
CORUM:5991	2.51655344529e-05	0.333333333333	FADD CASP8	LRRK2-FADD-CASP8 complex
CORUM:6414	2.51655344529e-05	0.333333333333	FADD CASP8	RIPK1-FADD-caspase-8 complex
GO:0043281	2.69481273944e-05	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	regulation of cysteine-type endopeptidase activity involved in apoptotic process
CORUM:2054	5.0322056017e-05	0.333333333333	FADD CASP8	CASP8-FADD-MALT1-BCL10 complex
GO:2000116	5.11490390245e-05	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	regulation of cysteine-type endopeptidase activity
REAC:R-HSA-5633008	5.85102183028e-05	0.5	TNFRSF10A FAS TNFRSF10B	TP53 Regulates Transcription of Cell Death Genes
GO:0071496	6.84894530877e-05	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	cellular response to external stimulus
KEGG:04115	6.94278084771e-05	0.5	FAS CASP8 TNFRSF10B	p53 signaling pathway
WP:WP707	7.12187442815e-05	0.5	FAS CASP8 TNFRSF10B	DNA Damage Response
WP:WP1530	8.13431193589e-05	0.5	FAS CASP8 TNFRSF10B	miRNA Regulation of DNA Damage Response
KEGG:01524	9.92621413242e-05	0.5	FADD CASP8 FAS	Platinum drug resistance
GO:0031264	0.000101639975642	0.5	FADD CASP8 FAS	death-inducing signaling complex
GO:0071214	0.000120195965124	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	cellular response to abiotic stimulus
GO:0104004	0.000120195965124	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	cellular response to environmental stimulus
WP:WP2059	0.000121904053629	0.5	FADD CASP8 FAS	Alzheimers Disease
KEGG:05142	0.000182197158451	0.5	FADD CASP8 FAS	Chagas disease (American trypanosomiasis)
KEGG:04668	0.000215290076423	0.5	FADD CASP8 FAS	TNF signaling pathway
KEGG:04650	0.000259985721773	0.5	TNFRSF10A FAS TNFRSF10B	Natural killer cell mediated cytotoxicity
GO:0052548	0.000308640170666	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	regulation of endopeptidase activity
REAC:R-HSA-9013957	0.000332336489066	0.333333333333	FADD CASP8	TLR3-mediated TICAM1-dependent programmed cell death
WP:WP2513	0.000368195468638	0.333333333333	FADD CASP8	Nanoparticle triggered regulated necrosis
GO:2001233	0.000371392762282	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	regulation of apoptotic signaling pathway
GO:0052547	0.000452658305655	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	regulation of peptidase activity
GO:0045862	0.000470494861301	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of proteolysis
KEGG:05162	0.000563363106539	0.5	FADD CASP8 FAS	Measles
REAC:R-HSA-2562578	0.000620139265586	0.333333333333	FADD CASP8	TRIF-mediated programmed cell death
KEGG:05160	0.000675855226254	0.5	FADD CASP8 FAS	Hepatitis C
WP:WP4666	0.000731117090022	0.5	FADD CASP8 FAS	Hepatitis B infection
KEGG:05010	0.000981167923329	0.5	FADD CASP8 FAS	Alzheimer disease
KEGG:05161	0.00100038089965	0.5	FADD CASP8 FAS	Hepatitis B
KEGG:05167	0.00120635789569	0.5	FADD CASP8 FAS	Kaposi sarcoma-associated herpesvirus infection
WP:WP3982	0.00128637745568	0.333333333333	TNFRSF10B CASP8	miRNA regulation of p53 pathway in prostate cancer
REAC:R-HSA-5357786	0.00146070989197	0.333333333333	FADD CASP8	TNFR1-induced proapoptotic signaling
REAC:R-HSA-933543	0.00146070989197	0.333333333333	FADD CASP8	NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
KEGG:05169	0.0016442646368	0.5	FADD CASP8 FAS	Epstein-Barr virus infection
KEGG:05170	0.00211201253822	0.5	FADD CASP8 FAS	Human immunodeficiency virus 1 infection
KEGG:05163	0.00220846662002	0.5	FADD CASP8 FAS	Human cytomegalovirus infection
KEGG:04215	0.00271009618492	0.333333333333	FADD CASP8	Apoptosis - multiple species
GO:0097190	0.00305393756634	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	apoptotic signaling pathway
GO:0051345	0.00399989556476	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of hydrolase activity
GO:0043065	0.00430914744721	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of apoptotic process
WP:WP2036	0.00432962199219	0.333333333333	FADD CASP8	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
GO:0043068	0.0046371909663	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of programmed cell death
GO:0070266	0.00592798461195	0.5	FADD CASP8 FAS	necroptotic process
GO:0045569	0.00676235117068	0.333333333333	TNFRSF10B TNFRSF10A	TRAIL binding
GO:0010942	0.00704880676626	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	positive regulation of cell death
GO:0043123	0.00710422530808	0.666666666667	FADD IL37 CASP8 TNFRSF10B	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0009967	0.00766830807857	1.0	IL37 TNFRSF10B TNFRSF10A FAS FADD CASP8	positive regulation of signal transduction
WP:WP3865	0.00792327646772	0.333333333333	FADD CASP8	Novel intracellular components of RIG-I-like receptor (RLR) pathway
KEGG:05165	0.0080443443451	0.5	FADD CASP8 FAS	Human papillomavirus infection
GO:0097300	0.00896978520187	0.5	FADD CASP8 FAS	programmed necrotic cell death
GO:0032270	0.00912288063822	1.0	IL37 TNFRSF10B TNFRSF10A FAS FADD CASP8	positive regulation of cellular protein metabolic process
WP:WP2328	0.00914590035486	0.333333333333	FAS CASP8	Allograft Rejection
GO:0030162	0.00934337825213	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	regulation of proteolysis
GO:0043066	0.0113691393447	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	negative regulation of apoptotic process
GO:0010647	0.011433350079	1.0	IL37 TNFRSF10B TNFRSF10A FAS FADD CASP8	positive regulation of cell communication
GO:0070265	0.0118307664632	0.5	FADD CASP8 FAS	necrotic cell death
GO:0023056	0.011912795611	1.0	IL37 TNFRSF10B TNFRSF10A FAS FADD CASP8	positive regulation of signaling
KEGG:04622	0.0124835568261	0.333333333333	FADD CASP8	RIG-I-like receptor signaling pathway
WP:WP4655	0.0125813796702	0.333333333333	FADD CASP8	Cytosolic DNA-sensing pathway
GO:0043069	0.0126929955851	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	negative regulation of programmed cell death
GO:0051247	0.0133854868067	1.0	IL37 TNFRSF10B TNFRSF10A FAS FADD CASP8	positive regulation of protein metabolic process
KEGG:05168	0.0142962779924	0.5	FADD CASP8 FAS	Herpes simplex virus 1 infection
KEGG:04657	0.014938172142	0.333333333333	FADD CASP8	IL-17 signaling pathway
REAC:R-HSA-75893	0.0171765331493	0.333333333333	FADD CASP8	TNF signaling
GO:0043122	0.018866162666	0.666666666667	FADD IL37 CASP8 TNFRSF10B	regulation of I-kappaB kinase/NF-kappaB signaling
GO:0035877	0.020283420769	0.333333333333	FADD CASP8	death effector domain binding
GO:1902531	0.0206904307747	1.0	IL37 TNFRSF10B TNFRSF10A FAS FADD CASP8	regulation of intracellular signal transduction
WP:WP231	0.021066272601	0.333333333333	FADD CASP8	TNF alpha Signaling Pathway
WP:WP75	0.021066272601	0.333333333333	FADD CASP8	Toll-like Receptor Signaling Pathway
GO:0060548	0.0210896164202	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	negative regulation of cell death
KEGG:04620	0.0225434657463	0.333333333333	FADD CASP8	Toll-like receptor signaling pathway
CORUM:6158	0.0249904952816	0.166666666667	TNFRSF10B	TRIAL-DR5 complex
KEGG:05200	0.0260948095216	0.5	FADD CASP8 FAS	Pathways in cancer
GO:0007249	0.0303912691926	0.666666666667	FADD IL37 CASP8 TNFRSF10B	I-kappaB kinase/NF-kappaB signaling
REAC:R-HSA-162582	0.0348492364063	0.833333333333	TNFRSF10A FADD CASP8 TNFRSF10B FAS	Signal Transduction
WP:WP1449	0.0377845147795	0.333333333333	FADD CASP8	Regulation of toll-like receptor signaling pathway
REAC:R-HSA-3700989	0.0393483138606	0.5	TNFRSF10A FAS TNFRSF10B	Transcriptional Regulation by TP53
HP:0030057	0.0394527338604	0.333333333333	FADD FAS	Autoimmune antibody positivity
GO:0045651	0.0405595771497	0.333333333333	FADD CASP8	positive regulation of macrophage differentiation
CORUM:1062	0.0499726005494	0.166666666667	CASP8	BAR-BCL2-CASP8 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
FADD	IL37	0.528	0.633	bioplex (FADD) bioplex_WMM
CASP8	TNFRSF10B	0.268	0.482	bioplex (TNFRSF10B) bioplex_WMM
FADD	TNFRSF10B	0.244	0.468	bioplex (TNFRSF10B) bioplex_WMM
CASP8	TNFRSF10A	0.126	0.4	bioplex (TNFRSF10A) bioplex_WMM
FAS	FADD	0.075	0.357	bioplex (FAS) bioplex_WMM
FADD	TNFRSF10A	0.053	0.298	bioplex (TNFRSF10A) bioplex_WMM
FAS	CASP8	0.052	0.301	bioplex (FAS) bioplex_WMM
TNFRSF10B	TNFRSF10A	0.019	0.186	bioplex (TNFRSF10A) bioplex_WMM
CASP8	FADD	0.013	0.15	bioplex_WMM WMM_only

Images

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Complex HuMAP2_05774 has an average edge precision of 0.364 which is ranked 3707 out of all 6965 complexes.

Related Complexes

Genename	Complexes
TNFRSF10B	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05774 HuMAP2_06332
IL37	HuMAP2_00418 HuMAP2_02134 HuMAP2_04304 HuMAP2_05457 HuMAP2_05774
FAS	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05774
TNFRSF10A	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05774
FADD	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05457 HuMAP2_05774
CASP8	HuMAP2_00418 HuMAP2_02013 HuMAP2_02134 HuMAP2_04236 HuMAP2_04304 HuMAP2_05774 HuMAP2_06332

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05774