hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05777
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CAST | Calpastatin (Calpain inhibitor) (Sperm BS-17 component) | UniProt NCBI |
| CAPNS2 | Calpain small subunit 2 (CSS2) (Calcium-dependent protease small subunit 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8862803 | 0.000351943927099 | 1.0 | CAST CAPNS2 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.000351943927099 | 1.0 | CAST CAPNS2 | Neurodegenerative Diseases |
| REAC:R-HSA-1474228 | 0.0136219059022 | 1.0 | CAST CAPNS2 | Degradation of the extracellular matrix |
| HP:0030318 | 0.0497341708567 | 0.5 | CAST | Angular cheilitis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAST | CAPNS2 | 0.991 | 0.909 | bioplex (CAPNS2) bioplex_WMM |
Images
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Complex HuMAP2_05777 has an average edge precision of 0.909 which is ranked 509 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CAST | HuMAP2_01189 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 HuMAP2_05777 |
| CAPNS2 | HuMAP2_01189 HuMAP2_01317 HuMAP2_01890 HuMAP2_02830 HuMAP2_04669 HuMAP2_05777 |