hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05778
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAP1B | Ras-related protein Rap-1b (GTP-binding protein smg p21B) | UniProt NCBI |
| RAB7A | Ras-related protein Rab-7a | UniProt NCBI |
| RAB2A | Ras-related protein Rab-2A | UniProt NCBI |
| RAB10 | Ras-related protein Rab-10 | UniProt NCBI |
| RAB5B | Ras-related protein Rab-5B | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0019003 | 5.75798079994e-08 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | GDP binding |
| REAC:R-HSA-8873719 | 2.03091825402e-07 | 0.8 | RAB10 RAB2A RAB7A RAB5B | RAB geranylgeranylation |
| GO:0032549 | 1.36300125932e-05 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | ribonucleoside binding |
| GO:0032550 | 1.36300125932e-05 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | purine ribonucleoside binding |
| GO:0001883 | 1.40086240541e-05 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | purine nucleoside binding |
| GO:0001882 | 1.5195214246e-05 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | nucleoside binding |
| GO:0032561 | 1.82781872721e-05 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | guanyl ribonucleotide binding |
| GO:0019001 | 1.87566738499e-05 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | guanyl nucleotide binding |
| GO:0003924 | 5.9036082881e-05 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | GTPase activity |
| GO:0032482 | 0.000118091273647 | 0.8 | RAB10 RAB2A RAB7A RAB5B | Rab protein signal transduction |
| GO:0007265 | 0.000149939619928 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | Ras protein signal transduction |
| REAC:R-HSA-8876198 | 0.000266353842167 | 0.6 | RAB10 RAB7A RAB5B | RAB GEFs exchange GTP for GDP on RABs |
| REAC:R-HSA-6798695 | 0.000505930001941 | 0.8 | RAB10 RAB7A RAP1B RAB5B | Neutrophil degranulation |
| GO:0007264 | 0.00066476318296 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | small GTPase mediated signal transduction |
| REAC:R-HSA-9007101 | 0.000681366686347 | 0.6 | RAB10 RAB7A RAB5B | Rab regulation of trafficking |
| KEGG:04144 | 0.00171388219445 | 0.6 | RAB10 RAB7A RAB5B | Endocytosis |
| GO:0032555 | 0.00194806448895 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | purine ribonucleotide binding |
| GO:0032553 | 0.00215469028943 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | ribonucleotide binding |
| GO:0017076 | 0.00219804317621 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | purine nucleotide binding |
| GO:0005525 | 0.00415715596103 | 0.8 | RAB10 RAB2A RAP1B RAB7A | GTP binding |
| GO:0017111 | 0.00425361077725 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | nucleoside-triphosphatase activity |
| GO:0016462 | 0.00595718342043 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | pyrophosphatase activity |
| GO:0016818 | 0.00605484060313 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016817 | 0.00605484060313 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | hydrolase activity, acting on acid anhydrides |
| GO:0000166 | 0.00672128970632 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | nucleotide binding |
| GO:1901265 | 0.0067748885078 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | nucleoside phosphate binding |
| REAC:R-HSA-168249 | 0.0093160298358 | 0.8 | RAB10 RAB7A RAP1B RAB5B | Innate Immune System |
| GO:0097367 | 0.00992532516881 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | carbohydrate derivative binding |
| REAC:R-HSA-8854214 | 0.012121451174 | 0.4 | RAB5B RAB7A | TBC/RABGAPs |
| GO:0030667 | 0.0141703303114 | 0.8 | RAB10 RAB7A RAP1B RAB5B | secretory granule membrane |
| KEGG:05146 | 0.0151578406027 | 0.4 | RAB5B RAB7A | Amoebiasis |
| MIRNA:hsa-miR-4747-3p | 0.0213323797514 | 0.4 | RAB5B RAB2A | hsa-miR-4747-3p |
| KEGG:04152 | 0.0262966325762 | 0.4 | RAB10 RAB2A | AMPK signaling pathway |
| GO:0036094 | 0.0285494817615 | 1.0 | RAB10 RAB7A RAB2A RAP1B RAB5B | small molecule binding |
| REAC:R-HSA-597592 | 0.035484350726 | 0.8 | RAB10 RAB2A RAB7A RAB5B | Post-translational protein modification |
| KEGG:04145 | 0.0381461453689 | 0.4 | RAB5B RAB7A | Phagosome |
| WP:WP4223 | 0.0390434201563 | 0.4 | RAB5B RAP1B | Ras Signaling |
| KEGG:05152 | 0.0470338525035 | 0.4 | RAB5B RAB7A | Tuberculosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB7A | RAB10 | 0.17 | 0.427 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RAB7A | RAB5B | 0.17 | 0.426 | hein_WMM bioplex_WMM Guru gupta_WMM fraction treiber_WMM |
| RAB7A | RAB2A | 0.135 | 0.407 | hein_WMM bioplex_WMM Guru boldt hein (RAB2A) gupta_WMM fraction boldt_WMM treiber_WMM |
| RAP1B | RAB7A | 0.11 | 0.379 | hein_WMM bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM |
| RAB5B | RAB10 | 0.01 | 0.137 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| RAP1B | RAB5B | 0.009 | 0.096 | bioplex_WMM Guru gupta_WMM fraction |
| RAP1B | RAB10 | 0.007 | 0.004 | bioplex_WMM boldt gupta_WMM boldt_WMM |
| RAP1B | RAB2A | 0.006 | 0.009 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM |
| RAB2A | RAB5B | 0.0 | 0.01 | bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM |
| RAB2A | RAB10 | 0.0 | 0.001 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_05778 has an average edge precision of 0.19 which is ranked 6315 out of all 6965 complexes.
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