hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05786
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDC123 | Cell division cycle protein 123 homolog (Protein D123) (HT-1080) (PZ32) | UniProt NCBI |
| METAP2 | Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) | UniProt NCBI |
| PYM1 | Partner of Y14 and mago (PYM homolog 1 exon junction complex-associated factor) (Protein wibg homolog) | UniProt NCBI |
| EIF2S2 | Eukaryotic translation initiation factor 2 subunit 2 (Eukaryotic translation initiation factor 2 subunit beta) (eIF-2-beta) | UniProt NCBI |
| RPS10 | 40S ribosomal protein S10 (Small ribosomal subunit protein eS10) | UniProt NCBI |
| DDX47 | Probable ATP-dependent RNA helicase DDX47 (EC 3.6.4.13) (DEAD box protein 47) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72695 | 0.029137346631 | 0.333333333333 | EIF2S2 RPS10 | Formation of the ternary complex, and subsequently, the 43S complex |
| REAC:R-HSA-72702 | 0.0375501136505 | 0.333333333333 | EIF2S2 RPS10 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72649 | 0.0375501136505 | 0.333333333333 | EIF2S2 RPS10 | Translation initiation complex formation |
| REAC:R-HSA-72662 | 0.0388379782234 | 0.333333333333 | EIF2S2 RPS10 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDC123 | EIF2S2 | 0.884 | 0.816 | bioplex (EIF2S2) bioplex_WMM youn_WMM gupta_WMM |
| EIF2S2 | PYM1 | 0.197 | 0.45 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| PYM1 | RPS10 | 0.083 | 0.349 | bioplex (PYM1) bioplex_WMM youn_WMM gupta_WMM fraction |
| RPS10 | DDX47 | 0.057 | 0.324 | hein_WMM bioplex (DDX47) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| EIF2S2 | RPS10 | 0.057 | 0.321 | hein_WMM bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| EIF2S2 | METAP2 | 0.047 | 0.29 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| EIF2S2 | DDX47 | 0.007 | 0.008 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| CDC123 | PYM1 | 0.007 | 0.006 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC123 | RPS10 | 0.007 | 0.007 | youn_WMM gupta_WMM WMM_only |
| CDC123 | DDX47 | 0.007 | 0.001 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDC123 | METAP2 | 0.007 | 0.0 | bioplex_WMM WMM_only |
| METAP2 | DDX47 | 0.007 | 0.002 | bioplex_WMM WMM_only treiber_WMM |
| METAP2 | RPS10 | 0.005 | 0.006 | fraction |
| PYM1 | DDX47 | 0.004 | 0.018 | hein_WMM youn_WMM gupta_WMM fraction |
| METAP2 | PYM1 | 0.0 | 0.003 | gupta_WMM fraction |
Images
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Complex HuMAP2_05786 has an average edge precision of 0.173 which is ranked 6493 out of all 6965 complexes.
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