hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05814
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTNNB1 | Catenin beta-1 (Beta-catenin) | UniProt NCBI |
| CDH24 | Cadherin-24 | UniProt NCBI |
| CTNND1 | Catenin delta-1 (Cadherin-associated Src substrate) (CAS) (p120 catenin) (p120(ctn)) (p120(cas)) | UniProt NCBI |
| PKP4 | Plakophilin-4 (p0071) | UniProt NCBI |
| CDH11 | Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin) | UniProt NCBI |
| CDH8 | Cadherin-8 | UniProt NCBI |
| ARVCF | Armadillo repeat protein deleted in velo-cardio-facial syndrome | UniProt NCBI |
| CDH5 | Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005913 | 5.89082792893e-14 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cell-cell adherens junction |
| REAC:R-HSA-418990 | 9.67913056005e-14 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | Adherens junctions interactions |
| REAC:R-HSA-421270 | 2.30369396892e-12 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | Cell-cell junction organization |
| GO:0016342 | 6.88404783182e-12 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | catenin complex |
| GO:0034329 | 2.54404554643e-11 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cell junction assembly |
| REAC:R-HSA-446728 | 4.65934508627e-11 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | Cell junction organization |
| GO:0034330 | 9.61784090977e-11 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cell junction organization |
| GO:0007043 | 1.00008445533e-10 | 0.875 | CDH24 ARVCF CDH11 CDH8 PKP4 CDH5 CTNND1 | cell-cell junction assembly |
| GO:0045216 | 3.927453121e-10 | 0.875 | CDH24 ARVCF CDH11 CDH8 PKP4 CDH5 CTNND1 | cell-cell junction organization |
| REAC:R-HSA-1500931 | 4.63451374059e-10 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | Cell-Cell communication |
| GO:0005911 | 5.58629161586e-10 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cell-cell junction |
| GO:0045296 | 1.97956052696e-09 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cadherin binding |
| WP:WP4540 | 1.69214292343e-08 | 0.625 | CDH24 CTNNB1 CDH5 CDH11 CDH8 | Pathways Regulating Hippo Signaling |
| CORUM:6337 | 1.8831701816e-08 | 0.375 | CTNNB1 CTNND1 CDH11 | Amot-cadherin-11-beta-catenin-p120 complex |
| GO:0050839 | 2.82751649541e-08 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cell adhesion molecule binding |
| GO:0005912 | 3.63579948379e-08 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | adherens junction |
| WP:WP4541 | 3.80475561763e-08 | 0.625 | CDH24 CTNNB1 CDH5 CDH11 CDH8 | Hippo-Merlin Signaling Dysregulation |
| GO:0070161 | 4.40606857713e-08 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | anchoring junction |
| GO:0098609 | 7.76253604209e-08 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cell-cell adhesion |
| GO:0044331 | 1.48175348117e-07 | 0.625 | CDH24 CDH5 CDH8 CTNND1 CDH11 | cell-cell adhesion mediated by cadherin |
| GO:0034332 | 1.74805482935e-07 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | adherens junction organization |
| GO:0019897 | 4.07171025486e-07 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | extrinsic component of plasma membrane |
| GO:0030054 | 9.8533617371e-07 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cell junction |
| GO:0007155 | 6.63497890886e-06 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cell adhesion |
| GO:0022610 | 7.01111546405e-06 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | biological adhesion |
| GO:0019898 | 1.36241343566e-05 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | extrinsic component of membrane |
| CORUM:826 | 3.50546248845e-05 | 0.25 | CTNNB1 CDH5 | PAR-3-VE-cadherin-beta-catenin complex |
| REAC:R-HSA-5218920 | 4.66197718087e-05 | 0.375 | CTNNB1 CTNND1 CDH5 | VEGFR2 mediated vascular permeability |
| GO:0016339 | 6.94441590143e-05 | 0.5 | CDH24 CDH5 CDH11 CDH8 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules |
| CORUM:5772 | 7.00904180673e-05 | 0.25 | CTNNB1 CDH5 | ZO1-(beta)cadherin-(VE)cadherin-VEGFR2 complex |
| GO:0098797 | 0.000469384667037 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | plasma membrane protein complex |
| KEGG:04670 | 0.000525250641096 | 0.375 | CTNNB1 CTNND1 CDH5 | Leukocyte transendothelial migration |
| GO:0007156 | 0.000666904519799 | 0.5 | CDH24 CDH5 CDH11 CDH8 | homophilic cell adhesion via plasma membrane adhesion molecules |
| REAC:R-HSA-8876493 | 0.00160842632192 | 0.25 | CTNNB1 CTNND1 | InlA-mediated entry of Listeria monocytogenes into host cells |
| REAC:R-HSA-4420097 | 0.0021428667452 | 0.375 | CTNNB1 CTNND1 CDH5 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.00276106254728 | 0.375 | CTNNB1 CTNND1 CDH5 | Signaling by VEGF |
| REAC:R-HSA-8876384 | 0.00761952471968 | 0.25 | CTNNB1 CTNND1 | Listeria monocytogenes entry into host cells |
| WP:WP3888 | 0.00841578083452 | 0.375 | CTNNB1 CTNND1 CDH5 | VEGFA-VEGFR2 Signaling Pathway |
| HP:0100338 | 0.0150657984869 | 0.25 | CTNND1 CDH11 | Non-midline cleft palate |
| GO:0022607 | 0.0157272559172 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cellular component assembly |
| HP:0009765 | 0.0173789434513 | 0.25 | CTNNB1 CDH11 | Low hanging columella |
| GO:0098742 | 0.0194680313645 | 0.5 | CDH24 CDH5 CDH11 CDH8 | cell-cell adhesion via plasma-membrane adhesion molecules |
| CORUM:6680 | 0.0248670854284 | 0.125 | CTNNB1 | CTNNB1-GLIS2 complex |
| CORUM:6599 | 0.0248670854284 | 0.125 | CTNND1 | CTNND1-GLIS2 complex |
| HP:0000670 | 0.02771617409 | 0.375 | ARVCF CTNND1 CDH11 | Carious teeth |
| KEGG:04520 | 0.0279665014883 | 0.25 | CTNNB1 CTNND1 | Adherens junction |
| GO:0044085 | 0.0296488714229 | 1.0 | CDH5 CDH24 ARVCF CDH11 CDH8 PKP4 CTNNB1 CTNND1 | cellular component biogenesis |
| HP:0004378 | 0.0334690521408 | 0.375 | ARVCF CTNND1 CDH11 | Abnormality of the anus |
| GO:0098796 | 0.048081979475 | 0.75 | CDH24 CDH5 CDH11 CDH8 CTNNB1 CTNND1 | membrane protein complex |
| CORUM:6339 | 0.0497224828424 | 0.125 | CTNNB1 | beta-catenin-B-cell lymphoma 9 protein complex |
| CORUM:6359 | 0.0497224828424 | 0.125 | CTNNB1 | RHAMM-beta-catenin complex |
| CORUM:6364 | 0.0497224828424 | 0.125 | CTNNB1 | OVOL2-beta-catenin-TCF4 complex |
| CORUM:6269 | 0.0497224828424 | 0.125 | CTNNB1 | DLL1-CTNNB1-CDH2 complex |
| CORUM:5281 | 0.0497224828424 | 0.125 | CTNNB1 | Cell-cell junction complex (CDH1-CTNNB1) |
| CORUM:6961 | 0.0497224828424 | 0.125 | CTNNB1 | CTNNB1-GID8 complex |
| CORUM:7312 | 0.0497224828424 | 0.125 | CTNNB1 | CTNNB1-ESR1 complex |
| CORUM:5262 | 0.0497224828424 | 0.125 | CTNNB1 | TCF4-CTNNB1 complex |
| CORUM:4096 | 0.0497224828424 | 0.125 | CTNNB1 | CTNNA1-CTNNB1 complex |
| CORUM:4095 | 0.0497224828424 | 0.125 | CTNNB1 | CTNNAL1-CTNNB1 complex |
| CORUM:3155 | 0.0497224828424 | 0.125 | CTNNB1 | TFC4-CTNNB1 complex |
| CORUM:829 | 0.0497224828424 | 0.125 | CDH5 | PAR-6-VE-cadherin complex, endothelial |
| CORUM:6334 | 0.0497224828424 | 0.125 | CTNNB1 | Afadin-beta-catenin complex |
| CORUM:6336 | 0.0497224828424 | 0.125 | CTNNB1 | CTNNB1-DNMT1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDH8 | CDH11 | 0.962 | 0.87 | bioplex (CDH8) bioplex_WMM |
| ARVCF | CDH8 | 0.518 | 0.632 | bioplex (CDH8) bioplex_WMM |
| CDH8 | PKP4 | 0.447 | 0.591 | bioplex (CDH8) bioplex_WMM |
| CDH24 | CDH8 | 0.359 | 0.541 | bioplex (CDH8) bioplex_WMM |
| CTNNB1 | CDH8 | 0.244 | 0.468 | bioplex (CDH8) bioplex_WMM |
| PKP4 | CDH5 | 0.194 | 0.447 | bioplex (CDH5) bioplex_WMM |
| CDH8 | CTNND1 | 0.092 | 0.356 | bioplex (CDH8) bioplex_WMM |
| ARVCF | CDH5 | 0.062 | 0.34 | bioplex (CDH5) bioplex_WMM |
| CTNNB1 | CDH5 | 0.03 | 0.231 | bioplex (CDH5) bioplex_WMM |
| CTNND1 | CDH5 | 0.013 | 0.151 | bioplex (CDH5) bioplex_WMM |
| ARVCF | CTNND1 | 0.012 | 0.147 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| CTNNB1 | ARVCF | 0.011 | 0.142 | hein_WMM bioplex_WMM WMM_only |
| ARVCF | PKP4 | 0.01 | 0.131 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| CTNNB1 | PKP4 | 0.01 | 0.097 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CTNNB1 | CDH24 | 0.01 | 0.1 | bioplex_WMM WMM_only |
| CDH24 | PKP4 | 0.009 | 0.112 | bioplex_WMM WMM_only |
| CDH24 | ARVCF | 0.009 | 0.112 | bioplex_WMM WMM_only |
| CDH24 | CDH11 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| CTNNB1 | CTNND1 | 0.008 | 0.082 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| CTNNB1 | CDH11 | 0.008 | 0.078 | bioplex_WMM WMM_only |
| CDH11 | PKP4 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| ARVCF | CDH11 | 0.008 | 0.066 | bioplex_WMM WMM_only |
| CDH24 | CTNND1 | 0.008 | 0.058 | bioplex_WMM WMM_only |
| CTNND1 | PKP4 | 0.008 | 0.023 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| CDH11 | CTNND1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05814 has an average edge precision of 0.237 which is ranked 5579 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CTNNB1 | HuMAP2_00343 HuMAP2_01868 HuMAP2_02943 HuMAP2_05814 |
| CDH24 | HuMAP2_00625 HuMAP2_04278 HuMAP2_04808 HuMAP2_05814 |
| CTNND1 | HuMAP2_01324 HuMAP2_01826 HuMAP2_02710 HuMAP2_03148 HuMAP2_04808 HuMAP2_05814 |
| PKP4 | HuMAP2_04808 HuMAP2_05814 |
| CDH11 | HuMAP2_00784 HuMAP2_01438 HuMAP2_03148 HuMAP2_04808 HuMAP2_05814 |
| CDH8 | HuMAP2_00784 HuMAP2_01438 HuMAP2_03148 HuMAP2_04808 HuMAP2_05814 |
| ARVCF | HuMAP2_00784 HuMAP2_04808 HuMAP2_05814 |
| CDH5 | HuMAP2_04808 HuMAP2_05814 |