hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05816
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAB3GAP1 | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | UniProt NCBI |
| SIRT2 | NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | UniProt NCBI |
| MTDH | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | UniProt NCBI |
| GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) | UniProt NCBI |
| RAB3GAP2 | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000064 | 0.0107072942689 | 0.4 | RAB3GAP1 RAB3GAP2 | Hypoplastic labia minora |
| HP:0000480 | 0.0107072942689 | 0.4 | RAB3GAP1 RAB3GAP2 | Retinal coloboma |
| HP:0009738 | 0.011725460578 | 0.4 | RAB3GAP1 RAB3GAP2 | Abnormality of the antihelix |
| HP:0000060 | 0.011725460578 | 0.4 | RAB3GAP1 RAB3GAP2 | Clitoral hypoplasia |
| HP:0040255 | 0.011725460578 | 0.4 | RAB3GAP1 RAB3GAP2 | Aplasia/Hypoplasia of the clitoris |
| GO:0097051 | 0.0135228859698 | 0.4 | RAB3GAP1 RAB3GAP2 | establishment of protein localization to endoplasmic reticulum membrane |
| HP:0001264 | 0.0150562782431 | 0.4 | RAB3GAP1 RAB3GAP2 | Spastic diplegia |
| REAC:R-HSA-6811436 | 0.0164283536306 | 0.4 | RAB3GAP1 RAB3GAP2 | COPI-independent Golgi-to-ER retrograde traffic |
| HP:0012880 | 0.0175069025895 | 0.4 | RAB3GAP1 RAB3GAP2 | Abnormality of the labia minora |
| HP:0009465 | 0.0201414164419 | 0.4 | RAB3GAP1 RAB3GAP2 | Ulnar deviation of finger |
| GO:0010506 | 0.0234344442687 | 0.8 | MTDH RAB3GAP2 RAB3GAP1 SIRT2 | regulation of autophagy |
| HP:0001845 | 0.0244376541782 | 0.4 | RAB3GAP1 RAB3GAP2 | Overlapping toe |
| HP:0000221 | 0.0244376541782 | 0.4 | RAB3GAP1 RAB3GAP2 | Furrowed tongue |
| GO:0050747 | 0.0270421395626 | 0.4 | RAB3GAP1 RAB3GAP2 | positive regulation of lipoprotein metabolic process |
| GO:1903373 | 0.0270421395626 | 0.4 | RAB3GAP1 RAB3GAP2 | positive regulation of endoplasmic reticulum tubular network organization |
| GO:1903061 | 0.0270421395626 | 0.4 | RAB3GAP1 RAB3GAP2 | positive regulation of protein lipidation |
| GO:0031331 | 0.0332526771576 | 0.8 | MTDH RAB3GAP2 RAB3GAP1 SIRT2 | positive regulation of cellular catabolic process |
| HP:0001193 | 0.0360671162807 | 0.4 | RAB3GAP1 RAB3GAP2 | Ulnar deviation of the hand or of fingers of the hand |
| HP:0000066 | 0.0437194132729 | 0.4 | RAB3GAP1 RAB3GAP2 | Labial hypoplasia |
| GO:1903059 | 0.0450641792523 | 0.4 | RAB3GAP1 RAB3GAP2 | regulation of protein lipidation |
| GO:1903371 | 0.0450641792523 | 0.4 | RAB3GAP1 RAB3GAP2 | regulation of endoplasmic reticulum tubular network organization |
| REAC:R-HSA-8876198 | 0.0476518941102 | 0.4 | RAB3GAP1 RAB3GAP2 | RAB GEFs exchange GTP for GDP on RABs |
| HP:0012815 | 0.0478196851342 | 0.4 | RAB3GAP1 RAB3GAP2 | Hypoplastic female external genitalia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB3GAP1 | SIRT2 | 0.826 | 0.774 | bioplex (SIRT2) bioplex_WMM youn_WMM |
| SIRT2 | RAB3GAP2 | 0.69 | 0.715 | bioplex (SIRT2) bioplex_WMM youn_WMM gupta_WMM |
| SIRT2 | GPAM | 0.125 | 0.399 | bioplex (SIRT2) bioplex_WMM |
| SIRT2 | MTDH | 0.041 | 0.27 | bioplex (SIRT2) bioplex_WMM youn_WMM gupta_WMM |
| RAB3GAP2 | GPAM | 0.008 | 0.091 | bioplex_WMM WMM_only |
| RAB3GAP2 | MTDH | 0.008 | 0.084 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| MTDH | GPAM | 0.008 | 0.067 | bioplex_WMM WMM_only |
| RAB3GAP1 | GPAM | 0.008 | 0.067 | bioplex_WMM WMM_only |
| RAB3GAP1 | MTDH | 0.008 | 0.068 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RAB3GAP1 | RAB3GAP2 | 0.0 | 0.003 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
Images
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Complex HuMAP2_05816 has an average edge precision of 0.254 which is ranked 5318 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RAB3GAP1 | HuMAP2_01070 HuMAP2_01196 HuMAP2_03258 HuMAP2_05816 HuMAP2_05846 HuMAP2_06645 |
| SIRT2 | HuMAP2_01196 HuMAP2_03258 HuMAP2_05816 HuMAP2_05846 HuMAP2_05876 HuMAP2_06645 |
| MTDH | HuMAP2_02915 HuMAP2_02952 HuMAP2_04124 HuMAP2_05816 HuMAP2_05876 HuMAP2_06645 |
| GPAM | HuMAP2_04031 HuMAP2_05816 HuMAP2_05846 HuMAP2_06645 |
| RAB3GAP2 | HuMAP2_01196 HuMAP2_05816 HuMAP2_05846 HuMAP2_06645 |