hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_05817

Confidence: Medium

Genename	Protein Name	Links
COG1	Conserved oligomeric Golgi complex subunit 1 (COG complex subunit 1) (Component of oligomeric Golgi complex 1)	UniProt NCBI
COG5	Conserved oligomeric Golgi complex subunit 5 (COG complex subunit 5) (13S Golgi transport complex 90 kDa subunit) (GTC-90) (Component of oligomeric Golgi complex 5) (Golgi transport complex 1)	UniProt NCBI
ATP7A	Copper-transporting ATPase 1 (EC 7.2.2.8) (Copper pump 1) (Menkes disease-associated protein)	UniProt NCBI
COG2	Conserved oligomeric Golgi complex subunit 2 (COG complex subunit 2) (Component of oligomeric Golgi complex 2) (Low density lipoprotein receptor defect C-complementing protein)	UniProt NCBI
COG7	Conserved oligomeric Golgi complex subunit 7 (COG complex subunit 7) (Component of oligomeric Golgi complex 7)	UniProt NCBI
COG3	Conserved oligomeric Golgi complex subunit 3 (COG complex subunit 3) (Component of oligomeric Golgi complex 3) (Vesicle-docking protein SEC34 homolog) (p94)	UniProt NCBI
COG6	Conserved oligomeric Golgi complex subunit 6 (COG complex subunit 6) (Component of oligomeric Golgi complex 6)	UniProt NCBI
COG8	Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) (Component of oligomeric Golgi complex 8)	UniProt NCBI
COG4	Conserved oligomeric Golgi complex subunit 4 (COG complex subunit 4) (Component of oligomeric Golgi complex 4)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:162	6.20402387647e-27	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	COG complex
CORUM:3522	6.20402387647e-27	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	COG complex
CORUM:3556	6.20402387647e-27	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	COG complex
GO:0017119	3.71501254947e-21	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Golgi transport complex
REAC:R-HSA-6811438	5.28925114923e-18	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Intra-Golgi traffic
REAC:R-HSA-6811440	9.38284389677e-18	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Retrograde transport at the Trans-Golgi-Network
CORUM:3551	8.53043734036e-16	0.555555555556	COG4 COG2 COG3 COG1 COG8	COG1-COG8-COG2-COG3-COG4 subcomplex
CORUM:3552	8.53043734036e-16	0.555555555556	COG5 COG8 COG6 COG1 COG7	COG1-COG8-COG5-COG6-COG7 subcomplex
REAC:R-HSA-6807878	4.29931724365e-15	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	COPI-mediated anterograde transport
GO:0099023	1.06328988676e-14	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	vesicle tethering complex
REAC:R-HSA-199977	1.1160194585e-13	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	ER to Golgi Anterograde Transport
GO:0032588	2.66373576331e-13	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	trans-Golgi network membrane
REAC:R-HSA-948021	4.13161761613e-13	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Transport to the Golgi and subsequent modification
GO:0005802	4.92351601973e-13	1.0	COG5 COG3 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	trans-Golgi network
REAC:R-HSA-6811442	1.44058707716e-12	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Intra-Golgi and retrograde Golgi-to-ER traffic
GO:0098791	2.40540743461e-12	1.0	COG5 COG3 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Golgi subcompartment
CORUM:3525	2.54036423996e-12	0.444444444444	COG8 COG6 COG7 COG5	Tetrameric COG subcomplex
HP:0012345	4.24582527277e-12	0.666666666667	COG5 COG2 COG8 COG4 COG6 COG1	Abnormal glycosylation
GO:0031984	5.11095136257e-12	1.0	COG5 COG3 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	organelle subcompartment
REAC:R-HSA-446203	2.87563095584e-11	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Asparagine N-linked glycosylation
GO:0006891	1.63972676246e-10	0.666666666667	COG5 COG3 COG8 COG2 COG6 COG1	intra-Golgi vesicle-mediated transport
GO:0006888	1.9843061044e-10	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	endoplasmic reticulum to Golgi vesicle-mediated transport
HP:0003160	7.58260155566e-10	0.555555555556	COG4 COG8 COG6 COG1 COG5	Abnormal isoelectric focusing of serum transferrin
HP:0012347	1.15164516192e-09	0.555555555556	COG4 COG8 COG6 COG1 COG5	Abnormal protein N-linked glycosylation
HP:0012346	1.15164516192e-09	0.555555555556	COG4 COG8 COG6 COG1 COG5	Abnormal protein glycosylation
HP:0032245	2.52970076053e-09	0.666666666667	COG5 COG2 COG8 COG4 COG6 COG1	Abnormal metabolism
CORUM:3544	6.30476064954e-09	0.333333333333	COG4 COG2 COG3	COG2-COG3-COG4 subcomplex
CORUM:3529	6.30476064954e-09	0.333333333333	COG6 COG7 COG5	COG5-COG6-COG7 subcomplex
CORUM:3545	6.30476064954e-09	0.333333333333	COG6 COG7 COG5	COG5-COG6-COG7 subcomplex
REAC:R-HSA-199991	8.8620324609e-09	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Membrane Trafficking
GO:0044431	1.31855254629e-08	1.0	COG5 COG3 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Golgi apparatus part
REAC:R-HSA-5653656	1.36160078985e-08	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Vesicle-mediated transport
GO:0048193	2.41593638878e-08	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Golgi vesicle transport
GO:0000139	1.32826284388e-07	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Golgi membrane
HP:0012301	4.23691944744e-07	0.333333333333	COG6 COG8 COG4	Type II transferrin isoform profile
GO:0005794	2.26924487573e-06	1.0	COG5 COG3 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Golgi apparatus
REAC:R-HSA-597592	4.23715743072e-06	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Post-translational protein modification
CORUM:3530	1.34129279418e-05	0.222222222222	COG7 COG5	Binary COG subcomplex
CORUM:3532	1.34129279418e-05	0.222222222222	COG1 COG8	COG1-COG8 subcomplex
GO:0098588	1.8971128254e-05	1.0	COG5 COG3 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	bounding membrane of organelle
HP:0002910	2.69089107715e-05	0.555555555556	COG4 COG2 COG6 COG7 COG8	Elevated hepatic transaminase
HP:0003808	6.41083112392e-05	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Abnormal muscle tone
HP:0000252	6.5093255533e-05	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Microcephaly
HP:0040195	6.71169323249e-05	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Decreased head circumference
REAC:R-HSA-392499	7.4753048218e-05	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	Metabolism of proteins
GO:0007030	0.000176069538454	0.555555555556	COG4 COG2 COG3 COG1 COG7	Golgi organization
HP:0001939	0.000221362679982	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Abnormality of metabolism/homeostasis
HP:0007364	0.000224327552455	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Aplasia/Hypoplasia of the cerebrum
HP:0007367	0.000251341393246	0.666666666667	COG5 COG4 COG7 COG2 COG6 COG1	Atrophy/Degeneration affecting the central nervous system
HP:0011804	0.000259462342531	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Abnormal muscle physiology
HP:0012443	0.000280566793848	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Abnormality of brain morphology
HP:0000240	0.000300893134759	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of skull size
HP:0410042	0.000348801463208	0.666666666667	COG2 COG7 COG8 COG4 ATP7A COG6	Abnormal liver morphology
HP:0000277	0.000455448898858	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of the mandible
HP:0012759	0.000559451398164	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Neurodevelopmental abnormality
HP:0002011	0.000570605595581	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Morphological abnormality of the central nervous system
HP:0030791	0.000612567257124	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormal jaw morphology
HP:0002977	0.000688025779416	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Aplasia/Hypoplasia involving the central nervous system
HP:0001252	0.000691751343301	0.777777777778	COG5 COG8 COG7 COG4 ATP7A COG6 COG1	Muscular hypotonia
HP:0003011	0.000717598669205	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Abnormality of the musculature
HP:0001263	0.000864520753222	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Global developmental delay
HP:0002715	0.000934512773112	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of the immune system
HP:0001511	0.000938758008668	0.555555555556	COG4 COG6 COG1 ATP7A COG7	Intrauterine growth retardation
HP:0012639	0.00110100217473	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Abnormality of nervous system morphology
HP:0001392	0.00117862136238	0.666666666667	COG2 COG7 COG8 COG4 ATP7A COG6	Abnormality of the liver
HP:0002028	0.00120210080552	0.333333333333	COG6 ATP7A COG4	Chronic diarrhea
HP:0002060	0.00132840917619	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of the cerebrum
HP:0100547	0.0014429040061	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of forebrain morphology
HP:0011821	0.00169546824614	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of facial skeleton
CORUM:0000000	0.00227951320903	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	CORUM root
GO:0031090	0.00246412233577	1.0	COG5 COG3 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	organelle membrane
HP:0002059	0.00278812869711	0.555555555556	COG4 COG2 COG6 COG1 COG7	Cerebral atrophy
GO:0046907	0.00285711818243	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	intracellular transport
HP:0007369	0.00293240663212	0.555555555556	COG4 COG2 COG6 COG1 COG7	Atrophy/Degeneration affecting the cerebrum
HP:0012758	0.00306355459929	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Neurodevelopmental delay
HP:0002012	0.00307736655255	0.666666666667	COG2 COG7 COG8 COG4 ATP7A COG6	Abnormality of the abdominal organs
HP:0000929	0.00374040704486	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormal skull morphology
HP:0002673	0.00433378542775	0.333333333333	COG4 COG8 ATP7A	Coxa valga
HP:0012444	0.00459828221014	0.555555555556	COG4 COG2 COG6 COG1 COG7	Brain atrophy
HP:0001531	0.00475695882991	0.333333333333	COG4 COG1 COG8	Failure to thrive in infancy
HP:0000347	0.00476871109168	0.555555555556	COG4 COG8 COG1 ATP7A COG7	Micrognathia
HP:0009118	0.00489977486351	0.555555555556	COG4 COG8 COG1 ATP7A COG7	Aplasia/Hypoplasia of the mandible
HP:0012638	0.00495411144597	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Abnormality of nervous system physiology
HP:0009116	0.00531010924848	0.555555555556	COG4 COG8 COG1 ATP7A COG7	Aplasia/Hypoplasia involving bones of the skull
GO:0016192	0.00544655604972	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	vesicle-mediated transport
HP:0010978	0.00561318596997	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of immune system physiology
HP:0001155	0.00580402617385	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of the hand
HP:0001272	0.00775554247762	0.444444444444	COG5 COG8 COG1 COG7	Cerebellar atrophy
HP:0000707	0.00828715040713	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Abnormality of the nervous system
HP:0009122	0.00921683554668	0.555555555556	COG4 COG8 COG1 ATP7A COG7	Aplasia/hypoplasia affecting bones of the axial skeleton
HP:0002817	0.00932206351039	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of the upper limb
HP:0002813	0.00990761822219	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of limb bone morphology
HP:0040068	0.00990761822219	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of limb bone
HP:0009121	0.0101934015787	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormal axial skeleton morphology
GO:0051649	0.0146372095025	0.888888888889	COG5 COG3 COG4 COG8 COG7 COG2 COG6 COG1	establishment of localization in cell
HP:0011844	0.0151918162414	0.666666666667	COG8 COG7 COG4 ATP7A COG6 COG1	Abnormal appendicular skeleton morphology
HP:0100874	0.0175215982818	0.222222222222	COG4 ATP7A	Thick hair
HP:0001508	0.0189778590116	0.555555555556	COG4 COG8 COG6 COG1 COG7	Failure to thrive
HP:0003367	0.0198132457486	0.333333333333	COG4 COG8 ATP7A	Abnormality of the femoral neck
HP:0001250	0.025701589363	0.666666666667	COG2 COG7 COG8 COG4 ATP7A COG6	Seizures
HP:0011842	0.0289663815659	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of skeletal morphology
HP:0000007	0.0291435385963	0.777777777778	COG5 COG4 COG8 COG7 COG2 COG6 COG1	Autosomal recessive inheritance
HP:0005484	0.0316768656643	0.333333333333	COG2 COG1 COG7	Postnatal microcephaly
GO:0010256	0.0317344723911	0.555555555556	COG4 COG2 COG3 COG1 COG7	endomembrane system organization
HP:0003366	0.0324459571885	0.333333333333	COG4 COG8 ATP7A	Abnormality of the femoral neck or head region
HP:0025408	0.0357713266755	0.444444444444	COG4 COG2 COG7 COG6	Abnormal spleen morphology
HP:0000005	0.0359437121659	0.888888888889	COG5 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	Mode of inheritance
HP:0000924	0.0362661646568	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of the skeletal system
HP:0000234	0.0369116385624	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of the head
HP:0009115	0.038274715273	0.555555555556	COG4 COG8 COG1 ATP7A COG7	Aplasia/hypoplasia involving the skeleton
HP:0000152	0.0385678121693	0.777777777778	COG2 COG8 COG7 COG4 ATP7A COG6 COG1	Abnormality of head or neck
HP:0032180	0.0405505356732	0.555555555556	COG4 COG2 COG6 COG7 COG8	Abnormal circulating metabolite concentration
HP:0001743	0.042704552104	0.444444444444	COG4 COG2 COG7 COG6	Abnormality of the spleen
GO:0012505	0.0445398812368	1.0	COG5 COG3 COG4 COG8 COG7 COG2 ATP7A COG6 COG1	endomembrane system

Edges

Protein 1	Protein 2	Score	Precision	Evidence
COG5	COG3	1.0	0.949	bioplex (COG3,COG5) bioplex_WMM fraction
COG8	COG3	1.0	0.949	bioplex (COG3) bioplex_WMM fraction
COG1	COG3	1.0	0.949	bioplex (COG3) bioplex_WMM fraction
COG2	COG3	0.999	0.949	bioplex (COG3) bioplex_WMM gupta_WMM fraction
COG5	COG8	0.999	0.949	bioplex (COG5) bioplex_WMM fraction
COG1	COG5	0.999	0.949	bioplex (COG5) bioplex_WMM Malo fraction
COG7	COG5	0.999	0.948	bioplex (COG5) bioplex_WMM Malo gupta_WMM fraction
COG7	COG3	0.998	0.943	bioplex (COG3) bioplex_WMM fraction
COG5	COG4	0.998	0.937	bioplex (COG5) bioplex_WMM Malo fraction
COG3	COG4	0.997	0.934	bioplex (COG3) bioplex_WMM fraction
COG5	COG6	0.997	0.934	bioplex (COG5,COG6) bioplex_WMM Malo fraction
COG7	COG6	0.996	0.926	bioplex (COG6) bioplex_WMM Malo fraction
COG6	COG4	0.965	0.875	bioplex (COG6) bioplex_WMM Malo fraction
COG7	COG4	0.949	0.856	bioplex_WMM Malo fraction
COG2	COG5	0.942	0.855	bioplex (COG5) bioplex_WMM fraction
COG1	COG4	0.94	0.853	bioplex_WMM Malo fraction
COG1	COG6	0.938	0.85	bioplex (COG6) bioplex_WMM Malo fraction
COG3	COG6	0.935	0.85	bioplex (COG3,COG6) bioplex_WMM fraction
COG2	COG6	0.617	0.674	bioplex (COG6) bioplex_WMM fraction
COG8	COG4	0.611	0.674	bioplex_WMM fraction
COG2	COG4	0.594	0.666	bioplex_WMM fraction
COG8	COG6	0.526	0.634	bioplex (COG6) bioplex_WMM fraction
COG2	COG8	0.476	0.609	bioplex_WMM fraction
COG1	COG7	0.402	0.561	bioplex_WMM youn_WMM Malo fraction
COG2	COG7	0.344	0.534	bioplex_WMM fraction
COG1	COG2	0.338	0.527	bioplex_WMM fraction
COG6	ATP7A	0.321	0.512	bioplex (COG6) bioplex_WMM
COG1	COG8	0.267	0.483	bioplex_WMM fraction
COG7	COG8	0.033	0.251	bioplex_WMM fraction
COG5	ATP7A	0.008	0.087	bioplex (COG5) bioplex_WMM
COG3	ATP7A	0.008	0.081	bioplex_WMM gupta_WMM WMM_only
COG7	ATP7A	0.008	0.054	bioplex_WMM WMM_only
COG1	ATP7A	0.008	0.04	bioplex_WMM WMM_only
COG8	ATP7A	0.008	0.033	bioplex_WMM WMM_only
COG2	ATP7A	0.008	0.025	bioplex_WMM gupta_WMM WMM_only
COG4	ATP7A	0.007	0.007	bioplex_WMM WMM_only

Images

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Complex HuMAP2_05817 has an average edge precision of 0.636 which is ranked 1736 out of all 6965 complexes.

Related Complexes

Genename	Complexes
COG1	HuMAP2_01954 HuMAP2_05817
COG5	HuMAP2_01954 HuMAP2_05817
ATP7A	HuMAP2_02575 HuMAP2_03618 HuMAP2_05817
COG2	HuMAP2_01954 HuMAP2_05817
COG7	HuMAP2_01954 HuMAP2_05817
COG3	HuMAP2_01954 HuMAP2_05817
COG6	HuMAP2_01954 HuMAP2_02575 HuMAP2_03618 HuMAP2_05817
COG8	HuMAP2_01954 HuMAP2_05817
COG4	HuMAP2_01954 HuMAP2_05817

hu.MAP 2.0: Complex View

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Complex: HuMAP2_05817