hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05819
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLD1 | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | UniProt NCBI |
| POLD4 | DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) | UniProt NCBI |
| POLD2 | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:297 | 2.25356268047e-09 | 1.0 | POLD4 POLD2 POLD1 | PCNA-DNA polymerase delta complex |
| WP:WP186 | 1.41702742731e-08 | 1.0 | POLD4 POLD2 POLD1 | Homologous recombination |
| CORUM:1107 | 2.70427521657e-08 | 1.0 | POLD4 POLD2 POLD1 | DNA synthesome core complex |
| KEGG:03430 | 5.3258178191e-08 | 1.0 | POLD4 POLD2 POLD1 | Mismatch repair |
| REAC:R-HSA-174437 | 5.39516293207e-08 | 1.0 | POLD4 POLD2 POLD1 | Removal of the Flap Intermediate from the C-strand |
| CORUM:1098 | 6.44518926616e-08 | 1.0 | POLD4 POLD2 POLD1 | DNA synthesome complex (13 subunits) |
| REAC:R-HSA-174414 | 7.41834903159e-08 | 1.0 | POLD4 POLD2 POLD1 | Processive synthesis on the C-strand of the telomere |
| CORUM:1108 | 1.02537101962e-07 | 1.0 | POLD4 POLD2 POLD1 | DNA synthesome complex (15 subunits) |
| KEGG:03410 | 1.49158985786e-07 | 1.0 | POLD4 POLD2 POLD1 | Base excision repair |
| CORUM:1111 | 1.53242262272e-07 | 1.0 | POLD4 POLD2 POLD1 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 1.53242262272e-07 | 1.0 | POLD4 POLD2 POLD1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-174411 | 1.63653275606e-07 | 1.0 | POLD4 POLD2 POLD1 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69109 | 1.63653275606e-07 | 1.0 | POLD4 POLD2 POLD1 | Leading Strand Synthesis |
| REAC:R-HSA-5358606 | 1.63653275606e-07 | 1.0 | POLD4 POLD2 POLD1 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-5358565 | 1.63653275606e-07 | 1.0 | POLD4 POLD2 POLD1 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-69091 | 1.63653275606e-07 | 1.0 | POLD4 POLD2 POLD1 | Polymerase switching |
| REAC:R-HSA-69166 | 1.63653275606e-07 | 1.0 | POLD4 POLD2 POLD1 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358508 | 2.04566594508e-07 | 1.0 | POLD4 POLD2 POLD1 | Mismatch Repair |
| REAC:R-HSA-69183 | 2.04566594508e-07 | 1.0 | POLD4 POLD2 POLD1 | Processive synthesis on the lagging strand |
| KEGG:03030 | 2.14716765829e-07 | 1.0 | POLD4 POLD2 POLD1 | DNA replication |
| KEGG:03440 | 2.97115076526e-07 | 1.0 | POLD4 POLD2 POLD1 | Homologous recombination |
| GO:0043625 | 3.63274304092e-07 | 1.0 | POLD4 POLD2 POLD1 | delta DNA polymerase complex |
| KEGG:03420 | 3.9827854995e-07 | 1.0 | POLD4 POLD2 POLD1 | Nucleotide excision repair |
| REAC:R-HSA-69186 | 5.12540478546e-07 | 1.0 | POLD4 POLD2 POLD1 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 5.97963891637e-07 | 1.0 | POLD4 POLD2 POLD1 | PCNA-Dependent Long Patch Base Excision Repair |
| WP:WP466 | 7.39430675706e-07 | 1.0 | POLD4 POLD2 POLD1 | DNA Replication |
| REAC:R-HSA-174417 | 9.09984147875e-07 | 1.0 | POLD4 POLD2 POLD1 | Telomere C-strand (Lagging Strand) Synthesis |
| REAC:R-HSA-110373 | 1.03407289531e-06 | 1.0 | POLD4 POLD2 POLD1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 1.03407289531e-06 | 1.0 | POLD4 POLD2 POLD1 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110314 | 1.82536345868e-06 | 1.0 | POLD4 POLD2 POLD1 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 1.82536345868e-06 | 1.0 | POLD4 POLD2 POLD1 | Extension of Telomeres |
| REAC:R-HSA-5656169 | 2.02093811497e-06 | 1.0 | POLD4 POLD2 POLD1 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 2.23000067859e-06 | 1.0 | POLD4 POLD2 POLD1 | DNA strand elongation |
| REAC:R-HSA-73933 | 2.94261178253e-06 | 1.0 | POLD4 POLD2 POLD1 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110313 | 3.79279954124e-06 | 1.0 | POLD4 POLD2 POLD1 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5696400 | 4.79270307132e-06 | 1.0 | POLD4 POLD2 POLD1 | Dual Incision in GG-NER |
| WP:WP4022 | 5.09350508747e-06 | 1.0 | POLD4 POLD2 POLD1 | Pyrimidine metabolism |
| REAC:R-HSA-73893 | 7.29021391195e-06 | 1.0 | POLD4 POLD2 POLD1 | DNA Damage Bypass |
| REAC:R-HSA-6782210 | 1.87320057001e-05 | 1.0 | POLD4 POLD2 POLD1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 1.96383930727e-05 | 1.0 | POLD4 POLD2 POLD1 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 1.96383930727e-05 | 1.0 | POLD4 POLD2 POLD1 | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-6781827 | 3.42035346017e-05 | 1.0 | POLD4 POLD2 POLD1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 3.8359608447e-05 | 1.0 | POLD4 POLD2 POLD1 | Telomere Maintenance |
| REAC:R-HSA-5696399 | 4.28393920683e-05 | 1.0 | POLD4 POLD2 POLD1 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-73884 | 4.7655024582e-05 | 1.0 | POLD4 POLD2 POLD1 | Base Excision Repair |
| GO:0042575 | 5.08584025729e-05 | 1.0 | POLD4 POLD2 POLD1 | DNA polymerase complex |
| REAC:R-HSA-73886 | 9.17879069632e-05 | 1.0 | POLD4 POLD2 POLD1 | Chromosome Maintenance |
| REAC:R-HSA-5696398 | 9.70320053332e-05 | 1.0 | POLD4 POLD2 POLD1 | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 0.000120004609098 | 1.0 | POLD4 POLD2 POLD1 | Synthesis of DNA |
| GO:0003887 | 0.000139860607076 | 1.0 | POLD4 POLD2 POLD1 | DNA-directed DNA polymerase activity |
| REAC:R-HSA-69306 | 0.000146343794532 | 1.0 | POLD4 POLD2 POLD1 | DNA Replication |
| GO:0006297 | 0.000160839698137 | 1.0 | POLD4 POLD2 POLD1 | nucleotide-excision repair, DNA gap filling |
| REAC:R-HSA-5693567 | 0.000160847790881 | 1.0 | POLD4 POLD2 POLD1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000184352717389 | 1.0 | POLD4 POLD2 POLD1 | Homology Directed Repair |
| GO:0043601 | 0.000208882724853 | 1.0 | POLD4 POLD2 POLD1 | nuclear replisome |
| GO:0032201 | 0.000265644334868 | 1.0 | POLD4 POLD2 POLD1 | telomere maintenance via semi-conservative replication |
| GO:0030894 | 0.000265644334868 | 1.0 | POLD4 POLD2 POLD1 | replisome |
| REAC:R-HSA-69242 | 0.000295546575822 | 1.0 | POLD4 POLD2 POLD1 | S Phase |
| GO:0034061 | 0.000297521655052 | 1.0 | POLD4 POLD2 POLD1 | DNA polymerase activity |
| REAC:R-HSA-5693532 | 0.000324502864875 | 1.0 | POLD4 POLD2 POLD1 | DNA Double-Strand Break Repair |
| GO:0006298 | 0.000408229499224 | 1.0 | POLD4 POLD2 POLD1 | mismatch repair |
| GO:0042769 | 0.000648444632805 | 1.0 | POLD4 POLD2 POLD1 | DNA damage response, detection of DNA damage |
| GO:0006296 | 0.0007056603357 | 1.0 | POLD4 POLD2 POLD1 | nucleotide-excision repair, DNA incision, 5'-to lesion |
| GO:0033683 | 0.000829990966275 | 1.0 | POLD4 POLD2 POLD1 | nucleotide-excision repair, DNA incision |
| GO:0019985 | 0.000897287531108 | 1.0 | POLD4 POLD2 POLD1 | translesion synthesis |
| GO:0043596 | 0.000968126020406 | 1.0 | POLD4 POLD2 POLD1 | nuclear replication fork |
| GO:0000731 | 0.00137862598403 | 1.0 | POLD4 POLD2 POLD1 | DNA synthesis involved in DNA repair |
| GO:0006301 | 0.00178004409005 | 1.0 | POLD4 POLD2 POLD1 | postreplication repair |
| GO:0033260 | 0.00200709053011 | 1.0 | POLD4 POLD2 POLD1 | nuclear DNA replication |
| REAC:R-HSA-73894 | 0.00245537461814 | 1.0 | POLD4 POLD2 POLD1 | DNA Repair |
| GO:0044786 | 0.00251749092736 | 1.0 | POLD4 POLD2 POLD1 | cell cycle DNA replication |
| GO:0005657 | 0.00378386515143 | 1.0 | POLD4 POLD2 POLD1 | replication fork |
| GO:0006283 | 0.00564855215433 | 1.0 | POLD4 POLD2 POLD1 | transcription-coupled nucleotide-excision repair |
| REAC:R-HSA-69278 | 0.0102351006549 | 1.0 | POLD4 POLD2 POLD1 | Cell Cycle, Mitotic |
| GO:0006289 | 0.0170248502613 | 1.0 | POLD4 POLD2 POLD1 | nucleotide-excision repair |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | POLD4 POLD2 POLD1 | Cell Cycle |
| GO:0016779 | 0.0201449224406 | 1.0 | POLD4 POLD2 POLD1 | nucleotidyltransferase activity |
| GO:0006261 | 0.0302766427817 | 1.0 | POLD4 POLD2 POLD1 | DNA-dependent DNA replication |
| GO:0090305 | 0.0310032822085 | 1.0 | POLD4 POLD2 POLD1 | nucleic acid phosphodiester bond hydrolysis |
| GO:0032993 | 0.0380729634404 | 1.0 | POLD4 POLD2 POLD1 | protein-DNA complex |
| GO:0071897 | 0.043337807111 | 1.0 | POLD4 POLD2 POLD1 | DNA biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLD1 | POLD2 | 0.998 | 0.945 | hein_WMM bioplex (POLD2) bioplex_WMM youn_WMM hein (POLD1) Malo fraction |
| POLD2 | POLD4 | 0.956 | 0.862 | hein_WMM bioplex (POLD2) bioplex_WMM |
| POLD1 | POLD4 | 0.018 | 0.176 | hein_WMM bioplex_WMM hein (POLD1) |
Images
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Complex HuMAP2_05819 has an average edge precision of 0.661 which is ranked 1590 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| POLD1 | HuMAP2_00586 HuMAP2_03648 HuMAP2_05209 HuMAP2_05819 HuMAP2_06286 |
| POLD4 | HuMAP2_02230 HuMAP2_05209 HuMAP2_05819 HuMAP2_06286 |
| POLD2 | HuMAP2_02230 HuMAP2_05209 HuMAP2_05819 HuMAP2_06286 |