hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05820
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTSB | Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain] | UniProt NCBI |
| GLUD1 | Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3) | UniProt NCBI |
| PDCD6 | Programmed cell death protein 6 (Apoptosis-linked gene 2 protein homolog) (ALG-2) | UniProt NCBI |
| ALDOB | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | UniProt NCBI |
| GLUD2 | Glutamate dehydrogenase 2, mitochondrial (GDH 2) (EC 1.4.1.3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00471 | 4.29182659546e-05 | 0.4 | GLUD1 GLUD2 | D-Glutamine and D-glutamate metabolism |
| KEGG:01200 | 0.000205667969449 | 0.6 | GLUD1 ALDOB GLUD2 | Carbon metabolism |
| HP:0012051 | 0.000278784943944 | 0.4 | GLUD1 ALDOB | Reactive hypoglycemia |
| KEGG:00910 | 0.000514258658532 | 0.4 | GLUD1 GLUD2 | Nitrogen metabolism |
| KEGG:04964 | 0.00081380532431 | 0.4 | GLUD1 GLUD2 | Proximal tubule bicarbonate reclamation |
| KEGG:00220 | 0.00081380532431 | 0.4 | GLUD1 GLUD2 | Arginine biosynthesis |
| REAC:R-HSA-8964539 | 0.000889652787086 | 0.4 | GLUD1 GLUD2 | Glutamate and glutamine metabolism |
| KEGG:00250 | 0.00225757376694 | 0.4 | GLUD1 GLUD2 | Alanine, aspartate and glutamate metabolism |
| WP:WP4290 | 0.00285983596887 | 0.4 | GLUD1 ALDOB | Metabolic reprogramming in colon cancer |
| GO:0004352 | 0.00450823411379 | 0.4 | GLUD1 GLUD2 | glutamate dehydrogenase (NAD+) activity |
| GO:0016639 | 0.00450823411379 | 0.4 | GLUD1 GLUD2 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor |
| GO:0004353 | 0.00450823411379 | 0.4 | GLUD1 GLUD2 | glutamate dehydrogenase [NAD(P)+] activity |
| REAC:R-HSA-2151201 | 0.0164283536306 | 0.4 | GLUD1 GLUD2 | Transcriptional activation of mitochondrial biogenesis |
| GO:0006537 | 0.0270421395626 | 0.4 | GLUD1 GLUD2 | glutamate biosynthetic process |
| MIRNA:hsa-miR-7151-5p | 0.0435496282017 | 0.4 | GLUD1 GLUD2 | hsa-miR-7151-5p |
| MIRNA:hsa-miR-885-5p | 0.0435496282017 | 0.4 | GLUD1 GLUD2 | hsa-miR-885-5p |
| KEGG:04217 | 0.0482876775804 | 0.4 | GLUD1 GLUD2 | Necroptosis |
| WP:WP690 | 0.0497141369515 | 0.2 | ALDOB | Polyol Pathway |
| CORUM:6375 | 0.0499494897235 | 0.2 | PDCD6 | PEF1-ALG2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CTSB | GLUD1 | 0.31 | 0.504 | bioplex_WMM boldt youn_WMM fraction boldt_WMM |
| ALDOB | GLUD1 | 0.084 | 0.349 | Guru fraction |
| GLUD2 | GLUD1 | 0.066 | 0.346 | bioplex (GLUD2) bioplex_WMM boldt_WMM |
| CTSB | PDCD6 | 0.027 | 0.228 | bioplex_WMM youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| GLUD1 | PDCD6 | 0.007 | 0.008 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| GLUD2 | CTSB | 0.007 | 0.002 | gupta_WMM WMM_only |
| GLUD2 | PDCD6 | 0.006 | 0.005 | hein_WMM gupta_WMM WMM_only |
Images
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Complex HuMAP2_05820 has an average edge precision of 0.206 which is ranked 6089 out of all 6965 complexes.
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