hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05834
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CCL22 | C-C motif chemokine 22 (CC chemokine STCP-1) (MDC(1-69)) (Macrophage-derived chemokine) (Small-inducible cytokine A22) (Stimulated T-cell chemotactic protein 1) [Cleaved into: MDC(3-69); MDC(5-69); MDC(7-69)] | UniProt NCBI |
| ZNF408 | Zinc finger protein 408 (PR domain zinc finger protein 17) | UniProt NCBI |
| CRIM1 | Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] | UniProt NCBI |
| FBLN5 | Fibulin-5 (FIBL-5) (Developmental arteries and neural crest EGF-like protein) (Dance) (Urine p50 protein) (UP50) | UniProt NCBI |
| FBN1 | Fibrillin-1 [Cleaved into: Asprosin] | UniProt NCBI |
| KRBA1 | Protein KRBA1 | UniProt NCBI |
| SEPHS2 | Selenide, water dikinase 2 (EC 2.7.9.3) (Selenium donor protein 2) (Selenophosphate synthase 2) | UniProt NCBI |
| LTBP4 | Latent-transforming growth factor beta-binding protein 4 (LTBP-4) | UniProt NCBI |
| UROS | Uroporphyrinogen-III synthase (UROIIIS) (UROS) (EC 4.2.1.75) (Hydroxymethylbilane hydrolyase [cyclizing]) (Uroporphyrinogen-III cosynthase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6914 | 1.34129279418e-05 | 0.222222222222 | FBLN5 FBN1 | ELN-FBLN5-FBN1 complex |
| REAC:R-HSA-2129379 | 0.00012239415243 | 0.333333333333 | LTBP4 FBN1 FBLN5 | Molecules associated with elastic fibres |
| REAC:R-HSA-1566948 | 0.000233741537372 | 0.333333333333 | LTBP4 FBN1 FBLN5 | Elastic fibre formation |
| HP:0002097 | 0.00111657431676 | 0.333333333333 | LTBP4 FBN1 FBLN5 | Emphysema |
| HP:0000973 | 0.00672243737522 | 0.333333333333 | LTBP4 FBN1 FBLN5 | Cutis laxa |
| HP:0008067 | 0.0215410066485 | 0.333333333333 | LTBP4 FBN1 FBLN5 | Abnormally lax or hyperextensible skin |
| HP:0004970 | 0.026930967926 | 0.222222222222 | FBLN5 FBN1 | Ascending tubular aorta aneurysm |
| HP:0000015 | 0.0305121976344 | 0.222222222222 | LTBP4 FBLN5 | Bladder diverticulum |
| HP:0002617 | 0.0417302732469 | 0.333333333333 | LTBP4 FBN1 FBLN5 | Dilatation |
| CORUM:6913 | 0.0499262710315 | 0.111111111111 | FBN1 | ELN-FBLN2-FBN1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CRIM1 | ZNF408 | 0.357 | 0.539 | bioplex (ZNF408) bioplex_WMM |
| ZNF408 | LTBP4 | 0.155 | 0.416 | bioplex (ZNF408) bioplex_WMM |
| FBN1 | ZNF408 | 0.139 | 0.406 | bioplex (ZNF408) bioplex_WMM |
| CRIM1 | KRBA1 | 0.132 | 0.404 | bioplex (KRBA1) bioplex_WMM |
| FBLN5 | ZNF408 | 0.044 | 0.275 | bioplex (ZNF408) bioplex_WMM |
| SEPHS2 | ZNF408 | 0.041 | 0.271 | bioplex (ZNF408) bioplex_WMM |
| SEPHS2 | CCL22 | 0.036 | 0.266 | bioplex (CCL22) bioplex_WMM |
| UROS | SEPHS2 | 0.025 | 0.211 | bioplex (UROS) bioplex_WMM |
| FBN1 | FBLN5 | 0.013 | 0.151 | bioplex_WMM WMM_only |
| FBLN5 | LTBP4 | 0.012 | 0.149 | bioplex_WMM WMM_only |
| FBN1 | LTBP4 | 0.012 | 0.144 | bioplex_WMM WMM_only |
| FBN1 | CRIM1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| SEPHS2 | CRIM1 | 0.008 | 0.046 | bioplex_WMM WMM_only |
| FBLN5 | CRIM1 | 0.008 | 0.034 | bioplex_WMM WMM_only |
| SEPHS2 | FBN1 | 0.008 | 0.013 | bioplex_WMM WMM_only |
| SEPHS2 | FBLN5 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| CRIM1 | LTBP4 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| SEPHS2 | LTBP4 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05834 has an average edge precision of 0.188 which is ranked 6327 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CCL22 | HuMAP2_00135 HuMAP2_01407 HuMAP2_01621 HuMAP2_05041 HuMAP2_05834 HuMAP2_06115 |
| ZNF408 | HuMAP2_05044 HuMAP2_05834 |
| CRIM1 | HuMAP2_04967 HuMAP2_05044 HuMAP2_05834 |
| FBLN5 | HuMAP2_04155 HuMAP2_05834 |
| FBN1 | HuMAP2_04155 HuMAP2_05834 |
| KRBA1 | HuMAP2_04967 HuMAP2_05044 HuMAP2_05834 |
| SEPHS2 | HuMAP2_00135 HuMAP2_01621 HuMAP2_05041 HuMAP2_05834 |
| LTBP4 | HuMAP2_05088 HuMAP2_05261 HuMAP2_05834 |
| UROS | HuMAP2_00135 HuMAP2_01621 HuMAP2_05041 HuMAP2_05834 |