hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05843
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IKBKG | NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier) | UniProt NCBI |
| CHUK | Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16) | UniProt NCBI |
| IKBKB | Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappa-B-kinase beta) (IKK-B) (IKK-beta) (IkBKB) (EC 2.7.11.10) (I-kappa-B kinase 2) (IKK2) (Nuclear factor NF-kappa-B inhibitor kinase beta) (NFKBIKB) | UniProt NCBI |
| MAP3K14 | Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (HsNIK) (Serine/threonine-protein kinase NIK) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5194 | 5.7134586066e-12 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) |
| WP:WP3849 | 7.50049867654e-12 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ |
| CORUM:5266 | 4.53902544858e-11 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | TNF-alpha/NF-kappa B signaling complex 6 |
| WP:WP262 | 9.06878476346e-11 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | EBV LMP1 signaling |
| CORUM:2100 | 6.75231048499e-10 | 0.75 | CHUK IKBKB MAP3K14 | CHUK-IKBKB-MAP3K14 complex |
| CORUM:2121 | 6.75231048499e-10 | 0.75 | IKBKG IKBKB CHUK | I-kappa-B kinase complex |
| CORUM:5844 | 6.75231048499e-10 | 0.75 | IKBKG IKBKB CHUK | I-kappa-B kinase complex |
| REAC:R-HSA-5602636 | 1.350462097e-09 | 0.75 | IKBKG IKBKB CHUK | IKBKB deficiency causes SCID |
| REAC:R-HSA-5603027 | 1.350462097e-09 | 0.75 | IKBKG IKBKB CHUK | IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) |
| CORUM:2118 | 2.70078815927e-09 | 0.75 | IKBKG IKBKB CHUK | CHUK-ERC1-IKBKB-IKBKG |
| WP:WP2795 | 2.9483778434e-09 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Cardiac Hypertrophic Response |
| WP:WP3863 | 3.48962594992e-09 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| WP:WP195 | 3.78661539246e-09 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | IL-1 signaling pathway |
| KEGG:05120 | 9.43033012544e-09 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Epithelial cell signaling in Helicobacter pylori infection |
| WP:WP288 | 1.26324459387e-08 | 0.75 | IKBKG IKBKB CHUK | NLR Proteins |
| WP:WP4479 | 1.26324459387e-08 | 0.75 | IKBKG IKBKB CHUK | Supression of HMGB1 mediated inflammation by THBD |
| WP:WP4562 | 1.26324459387e-08 | 0.75 | IKBKG IKBKB CHUK | Canonical NF-KB pathway |
| CORUM:2105 | 1.3502580449e-08 | 0.75 | CHUK IKBKB MAP3K14 | IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) |
| WP:WP4480 | 1.89477142991e-08 | 0.75 | IKBKG IKBKB CHUK | Role Altered Glycolysation of MUC1 in Tumour Microenvironment |
| WP:WP1544 | 1.94403076556e-08 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | MicroRNAs in cardiomyocyte hypertrophy |
| WP:WP69 | 2.05055299929e-08 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | T-Cell antigen Receptor (TCR) Signaling Pathway |
| CORUM:2727 | 2.3628325482e-08 | 0.75 | IKBKG IKBKB CHUK | SRC-3 complex |
| KEGG:04064 | 2.71513743162e-08 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | NF-kappa B signaling pathway |
| WP:WP231 | 3.53340158765e-08 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | TNF alpha Signaling Pathway |
| KEGG:04625 | 4.21390856008e-08 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | C-type lectin receptor signaling pathway |
| KEGG:04660 | 4.61742921563e-08 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | T cell receptor signaling pathway |
| REAC:R-HSA-5603029 | 4.72566509639e-08 | 0.75 | IKBKG IKBKB CHUK | IkBA variant leads to EDA-ID |
| KEGG:04668 | 5.27619069067e-08 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | TNF signaling pathway |
| WP:WP1434 | 6.44994549636e-08 | 0.75 | CHUK IKBKB MAP3K14 | Osteopontin Signaling |
| KEGG:04380 | 7.98959151974e-08 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Osteoclast differentiation |
| KEGG:04210 | 1.7513076548e-07 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Apoptosis |
| REAC:R-HSA-5607764 | 2.53401411634e-07 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | CLEC7A (Dectin-1) signaling |
| REAC:R-HSA-933543 | 2.96966986958e-07 | 0.75 | IKBKG IKBKB CHUK | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| WP:WP712 | 2.99824100707e-07 | 0.75 | IKBKG IKBKB CHUK | Estrogen signaling pathway |
| WP:WP4482 | 2.99824100707e-07 | 0.75 | IKBKG IKBKB CHUK | Vitamin D in inflammatory diseases |
| CORUM:6344 | 3.07044439662e-07 | 0.75 | IKBKG IKBKB CHUK | TNF-R1-associated signaling complex |
| REAC:R-HSA-937039 | 4.9129586178e-07 | 0.75 | IKBKG IKBKB CHUK | IRAK1 recruits IKK complex |
| REAC:R-HSA-975144 | 4.9129586178e-07 | 0.75 | IKBKG IKBKB CHUK | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation |
| WP:WP3851 | 5.8597456504e-07 | 0.75 | IKBKG IKBKB CHUK | TLR4 Signaling and Tolerance |
| KEGG:01523 | 6.98828925714e-07 | 0.75 | IKBKG IKBKB CHUK | Antifolate resistance |
| WP:WP3858 | 7.38253492454e-07 | 0.75 | IKBKG IKBKB CHUK | Toll-like Receptor Signaling |
| WP:WP2112 | 7.38253492454e-07 | 0.75 | IKBKG IKBKB MAP3K14 | IL17 signaling pathway |
| REAC:R-HSA-5684264 | 7.55763607906e-07 | 0.75 | IKBKG IKBKB CHUK | MAP3K8 (TPL2)-dependent MAPK1/3 activation |
| KEGG:05169 | 8.17032558425e-07 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Epstein-Barr virus infection |
| WP:WP4496 | 8.23395062249e-07 | 0.75 | CHUK IKBKB MAP3K14 | Signal transduction through IL1R |
| REAC:R-HSA-5621481 | 9.07725736124e-07 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | C-type lectin receptors (CLRs) |
| WP:WP4481 | 9.14837263068e-07 | 0.75 | IKBKG IKBKB CHUK | Resistin as a regulator of inflammation |
| WP:WP4329 | 9.14837263068e-07 | 0.75 | IKBKG IKBKB CHUK | miRNAs involvement in the immune response in sepsis |
| REAC:R-HSA-1810476 | 9.1766670065e-07 | 0.75 | IKBKG IKBKB CHUK | RIP-mediated NFkB activation via ZBP1 |
| KEGG:05166 | 1.09982717057e-06 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-168927 | 1.30754323077e-06 | 0.75 | IKBKG IKBKB CHUK | TICAM1, RIP1-mediated IKK complex recruitment |
| WP:WP4136 | 1.34809896275e-06 | 0.75 | IKBKG IKBKB CHUK | Fibrin Complement Receptor 3 Signaling Pathway |
| CORUM:5233 | 1.36522213713e-06 | 0.75 | IKBKG IKBKB CHUK | TNF-alpha/NF-kappa B signaling complex 5 |
| WP:WP382 | 1.41282311447e-06 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | MAPK Signaling Pathway |
| REAC:R-HSA-1606322 | 1.7944862533e-06 | 0.75 | IKBKG IKBKB CHUK | ZBP1(DAI) mediated induction of type I IFNs |
| REAC:R-HSA-937041 | 1.7944862533e-06 | 0.75 | IKBKG IKBKB CHUK | IKK complex recruitment mediated by RIP1 |
| WP:WP1433 | 1.9001116486e-06 | 0.75 | IKBKG IKBKB CHUK | Nucleotide-binding Oligomerization Domain (NOD) pathway |
| REAC:R-HSA-933542 | 2.0777214413e-06 | 0.75 | IKBKG IKBKB CHUK | TRAF6 mediated NF-kB activation |
| WP:WP2036 | 2.22513142446e-06 | 0.75 | CHUK IKBKB MAP3K14 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| REAC:R-HSA-5260271 | 2.38925919874e-06 | 0.75 | IKBKG IKBKB CHUK | Diseases of Immune System |
| REAC:R-HSA-5602358 | 2.38925919874e-06 | 0.75 | IKBKG IKBKB CHUK | Diseases associated with the TLR signaling cascade |
| KEGG:04010 | 3.15864042444e-06 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | MAPK signaling pathway |
| WP:WP2637 | 4.14749023399e-06 | 0.75 | CHUK IKBKB MAP3K14 | Structural Pathway of Interleukin 1 (IL-1) |
| REAC:R-HSA-5357956 | 4.92812658075e-06 | 0.75 | IKBKG IKBKB CHUK | TNFR1-induced NFkappaB signaling pathway |
| WP:WP2018 | 4.97425382323e-06 | 0.75 | IKBKG IKBKB CHUK | RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway |
| CORUM:2101 | 5.02777038712e-06 | 0.5 | CHUK IKBKB | IKKA-IKKB complex |
| CORUM:6152 | 5.02777038712e-06 | 0.5 | IKBKG CHUK | IKBKG-CHUK complex |
| CORUM:2104 | 5.02777038712e-06 | 0.5 | IKBKB MAP3K14 | IKKB-NIK complex |
| CORUM:5828 | 5.02777038712e-06 | 0.5 | IKBKG IKBKB | IKBKG-IKBKB complex |
| CORUM:5829 | 5.02777038712e-06 | 0.5 | IKBKG CHUK | IKBKG-CHUK complex |
| REAC:R-HSA-445989 | 5.47542005033e-06 | 0.75 | IKBKG IKBKB CHUK | TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| REAC:R-HSA-5357905 | 5.47542005033e-06 | 0.75 | IKBKG IKBKB CHUK | Regulation of TNFR1 signaling |
| WP:WP3865 | 5.58230464391e-06 | 0.75 | IKBKG IKBKB CHUK | Novel intracellular components of RIG-I-like receptor (RLR) pathway |
| KEGG:04623 | 8.2801044538e-06 | 0.75 | IKBKG IKBKB CHUK | Cytosolic DNA-sensing pathway |
| REAC:R-HSA-168638 | 8.82452886806e-06 | 0.75 | IKBKG IKBKB CHUK | NOD1/2 Signaling Pathway |
| KEGG:05221 | 9.18189503509e-06 | 0.75 | IKBKG IKBKB CHUK | Acute myeloid leukemia |
| WP:WP3303 | 9.82501322372e-06 | 0.75 | IKBKG IKBKB CHUK | RAC1/PAK1/p38/MMP2 Pathway |
| KEGG:05131 | 1.1177007069e-05 | 0.75 | IKBKG IKBKB CHUK | Shigellosis |
| KEGG:04920 | 1.1177007069e-05 | 0.75 | IKBKG IKBKB CHUK | Adipocytokine signaling pathway |
| KEGG:04622 | 1.1177007069e-05 | 0.75 | IKBKG IKBKB CHUK | RIG-I-like receptor signaling pathway |
| WP:WP4655 | 1.12709645256e-05 | 0.75 | IKBKG IKBKB CHUK | Cytosolic DNA-sensing pathway |
| KEGG:04662 | 1.28493032652e-05 | 0.75 | IKBKG IKBKB CHUK | B cell receptor signaling pathway |
| REAC:R-HSA-75893 | 1.33177010906e-05 | 0.75 | IKBKG IKBKB CHUK | TNF signaling |
| WP:WP254 | 1.39841925682e-05 | 0.75 | IKBKG IKBKB CHUK | Apoptosis |
| WP:WP2034 | 1.4574337259e-05 | 0.75 | IKBKG IKBKB CHUK | Leptin signaling pathway |
| KEGG:04657 | 1.46803932603e-05 | 0.75 | IKBKG IKBKB CHUK | IL-17 signaling pathway |
| KEGG:04658 | 1.5327283042e-05 | 0.75 | IKBKG IKBKB CHUK | Th1 and Th2 cell differentiation |
| KEGG:05212 | 1.5327283042e-05 | 0.75 | IKBKG IKBKB CHUK | Pancreatic cancer |
| KEGG:05220 | 1.7381246657e-05 | 0.75 | IKBKG IKBKB CHUK | Chronic myeloid leukemia |
| WP:WP4263 | 2.06481472174e-05 | 0.75 | IKBKG IKBKB CHUK | Pancreatic adenocarcinoma pathway |
| KEGG:05235 | 2.20228638729e-05 | 0.75 | IKBKG IKBKB CHUK | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP75 | 2.46544135014e-05 | 0.75 | IKBKG IKBKB CHUK | Toll-like Receptor Signaling Pathway |
| WP:WP23 | 2.46544135014e-05 | 0.75 | IKBKG IKBKB CHUK | B Cell Receptor Signaling Pathway |
| KEGG:04659 | 2.74237602459e-05 | 0.75 | IKBKG IKBKB CHUK | Th17 cell differentiation |
| KEGG:04620 | 2.74237602459e-05 | 0.75 | IKBKG IKBKB CHUK | Toll-like receptor signaling pathway |
| KEGG:05142 | 2.94026709165e-05 | 0.75 | IKBKG IKBKB CHUK | Chagas disease (American trypanosomiasis) |
| GO:0008385 | 3.05058200216e-05 | 0.75 | IKBKG IKBKB CHUK | IkappaB kinase complex |
| WP:WP4658 | 3.10867203099e-05 | 0.75 | IKBKG IKBKB CHUK | Small cell lung cancer |
| KEGG:05215 | 3.14744143419e-05 | 0.75 | IKBKG IKBKB CHUK | Prostate cancer |
| REAC:R-HSA-168643 | 3.15562563454e-05 | 0.75 | IKBKG IKBKB CHUK | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| KEGG:05222 | 3.36411053102e-05 | 0.75 | IKBKG IKBKB CHUK | Small cell lung cancer |
| KEGG:05145 | 3.59048577419e-05 | 0.75 | IKBKG IKBKB CHUK | Toxoplasmosis |
| CORUM:2055 | 5.02641999304e-05 | 0.5 | CHUK IKBKB | CASP8-CHUK-IKBKB-MALT1-BCL10 complex |
| REAC:R-HSA-1834949 | 5.34661380805e-05 | 0.75 | IKBKG IKBKB CHUK | Cytosolic sensors of pathogen-associated DNA |
| REAC:R-HSA-450294 | 5.34661380805e-05 | 0.75 | IKBKG IKBKB CHUK | MAP kinase activation |
| WP:WP1449 | 5.98770817475e-05 | 0.75 | IKBKG IKBKB CHUK | Regulation of toll-like receptor signaling pathway |
| KEGG:05135 | 6.09947630131e-05 | 0.75 | IKBKG IKBKB CHUK | Yersinia infection |
| REAC:R-HSA-1169091 | 6.16010596593e-05 | 0.75 | IKBKG IKBKB CHUK | Activation of NF-kappaB in B cells |
| WP:WP3929 | 6.95487562915e-05 | 0.75 | IKBKG IKBKB CHUK | Chemokine signaling pathway |
| REAC:R-HSA-448424 | 7.05209067921e-05 | 0.75 | IKBKG IKBKB CHUK | Interleukin-17 signaling |
| REAC:R-HSA-168928 | 8.02616571278e-05 | 0.75 | IKBKG IKBKB CHUK | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| KEGG:05418 | 8.49786152038e-05 | 0.75 | IKBKG IKBKB CHUK | Fluid shear stress and atherosclerosis |
| KEGG:05162 | 9.12832394729e-05 | 0.75 | IKBKG IKBKB CHUK | Measles |
| WP:WP2380 | 9.19001123239e-05 | 0.75 | IKBKG IKBKB CHUK | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-2871837 | 9.45884271068e-05 | 0.75 | IKBKG IKBKB CHUK | FCERI mediated NF-kB activation |
| KEGG:04062 | 9.56545898299e-05 | 0.75 | IKBKG IKBKB CHUK | Chemokine signaling pathway |
| REAC:R-HSA-1168372 | 9.84181176004e-05 | 0.75 | IKBKG IKBKB CHUK | Downstream signaling events of B Cell Receptor (BCR) |
| KEGG:05160 | 0.000109599393216 | 0.75 | IKBKG IKBKB CHUK | Hepatitis C |
| WP:WP4666 | 0.000111482542004 | 0.75 | IKBKG IKBKB CHUK | Hepatitis B infection |
| REAC:R-HSA-168176 | 0.000119121057505 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.000119121057505 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-1236974 | 0.000119121057505 | 0.75 | IKBKG IKBKB CHUK | ER-Phagosome pathway |
| REAC:R-HSA-975871 | 0.000119121057505 | 0.75 | IKBKG IKBKB CHUK | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-975138 | 0.00012815247216 | 0.75 | IKBKG IKBKB CHUK | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 0.000132834259164 | 0.75 | IKBKG IKBKB CHUK | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 0.000132834259164 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| WP:WP4223 | 0.000136289943844 | 0.75 | IKBKG IKBKB CHUK | Ras Signaling |
| KEGG:05164 | 0.000141415901292 | 0.75 | IKBKG IKBKB CHUK | Influenza A |
| REAC:R-HSA-168188 | 0.000152699585722 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168138 | 0.000152699585722 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-202424 | 0.000152699585722 | 0.75 | IKBKG IKBKB CHUK | Downstream TCR signaling |
| REAC:R-HSA-166058 | 0.000152699585722 | 0.75 | IKBKG IKBKB CHUK | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168164 | 0.000157957097998 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor 3 (TLR3) Cascade |
| KEGG:05161 | 0.000162538377473 | 0.75 | IKBKG IKBKB CHUK | Hepatitis B |
| REAC:R-HSA-181438 | 0.000168830825906 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 0.000168830825906 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor TLR1:TLR2 Cascade |
| KEGG:04621 | 0.000172197671977 | 0.75 | IKBKG IKBKB CHUK | NOD-like receptor signaling pathway |
| REAC:R-HSA-937061 | 0.000174449693762 | 0.75 | IKBKG IKBKB CHUK | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166166 | 0.000174449693762 | 0.75 | IKBKG IKBKB CHUK | MyD88-independent TLR4 cascade |
| REAC:R-HSA-1236975 | 0.000180191665247 | 0.75 | IKBKG IKBKB CHUK | Antigen processing-Cross presentation |
| KEGG:05167 | 0.000196203606831 | 0.75 | IKBKG IKBKB CHUK | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-9020702 | 0.000198169454442 | 0.75 | IKBKG IKBKB CHUK | Interleukin-1 signaling |
| REAC:R-HSA-983705 | 0.000223943669275 | 0.75 | IKBKG IKBKB CHUK | Signaling by the B Cell Receptor (BCR) |
| CORUM:5286 | 0.000226087640536 | 0.5 | IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex 10 |
| KEGG:05130 | 0.000242354366577 | 0.75 | IKBKG IKBKB CHUK | Pathogenic Escherichia coli infection |
| REAC:R-HSA-202403 | 0.00026664242496 | 0.75 | IKBKG IKBKB CHUK | TCR signaling |
| KEGG:04014 | 0.00027234077557 | 0.75 | IKBKG IKBKB CHUK | Ras signaling pathway |
| GO:0033209 | 0.000285834009959 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | tumor necrosis factor-mediated signaling pathway |
| CORUM:5193 | 0.000331535811226 | 0.5 | IKBKG CHUK | TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) |
| CORUM:5230 | 0.000331535811226 | 0.5 | IKBKG CHUK | CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
| KEGG:05170 | 0.000344687561831 | 0.75 | IKBKG IKBKB CHUK | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-166016 | 0.000358372124957 | 0.75 | IKBKG IKBKB CHUK | Toll Like Receptor 4 (TLR4) Cascade |
| KEGG:05163 | 0.000360539009602 | 0.75 | IKBKG IKBKB CHUK | Human cytomegalovirus infection |
| REAC:R-HSA-2454202 | 0.000377028841718 | 0.75 | IKBKG IKBKB CHUK | Fc epsilon receptor (FCERI) signaling |
| REAC:R-HSA-73887 | 0.000436852235365 | 0.75 | IKBKG IKBKB CHUK | Death Receptor Signalling |
| REAC:R-HSA-446652 | 0.000436852235365 | 0.75 | IKBKG IKBKB CHUK | Interleukin-1 family signaling |
| GO:0043123 | 0.000481080494257 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| REAC:R-HSA-168898 | 0.000600269105338 | 0.75 | IKBKG IKBKB CHUK | Toll-like Receptor Cascades |
| REAC:R-HSA-1280218 | 0.000660113802024 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Adaptive Immune System |
| CORUM:5232 | 0.000682858782186 | 0.5 | IKBKG CHUK | TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) |
| WP:WP3617 | 0.000729007032317 | 0.5 | CHUK IKBKB | Photodynamic therapy-induced NF-kB survival signaling |
| REAC:R-HSA-1280215 | 0.000849103795306 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Cytokine Signaling in Immune system |
| WP:WP4172 | 0.000867148271367 | 0.75 | IKBKG IKBKB CHUK | PI3K-Akt Signaling Pathway |
| GO:0071356 | 0.00103185430137 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | cellular response to tumor necrosis factor |
| GO:0035666 | 0.00106129291317 | 0.75 | IKBKG IKBKB CHUK | TRIF-dependent toll-like receptor signaling pathway |
| KEGG:04151 | 0.00118089914293 | 0.75 | IKBKG IKBKB CHUK | PI3K-Akt signaling pathway |
| WP:WP2332 | 0.00124082421052 | 0.5 | CHUK IKBKB | Interleukin-11 Signaling Pathway |
| GO:0043122 | 0.0012832593435 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | regulation of I-kappaB kinase/NF-kappaB signaling |
| KEGG:05165 | 0.00132804938561 | 0.75 | IKBKG IKBKB CHUK | Human papillomavirus infection |
| GO:0034612 | 0.0014249330287 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | response to tumor necrosis factor |
| GO:0002756 | 0.00163061517788 | 0.75 | IKBKG IKBKB CHUK | MyD88-independent toll-like receptor signaling pathway |
| GO:0009615 | 0.00184822285327 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | response to virus |
| GO:0007249 | 0.00207257982907 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | I-kappaB kinase/NF-kappaB signaling |
| WP:WP395 | 0.00221783487587 | 0.5 | CHUK IKBKB | IL-4 Signaling Pathway |
| KEGG:05168 | 0.00237639508828 | 0.75 | IKBKG IKBKB CHUK | Herpes simplex virus 1 infection |
| REAC:R-HSA-168249 | 0.00243001134371 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Innate Immune System |
| GO:0008384 | 0.00270494046827 | 0.5 | CHUK IKBKB | IkappaB kinase activity |
| WP:WP2324 | 0.0034749006715 | 0.5 | CHUK IKBKB | AGE/RAGE pathway |
| KEGG:05200 | 0.00437599198048 | 0.75 | IKBKG IKBKB CHUK | Pathways in cancer |
| WP:WP1772 | 0.00540505574756 | 0.5 | IKBKB MAP3K14 | Apoptosis Modulation and Signaling |
| GO:0010803 | 0.00587743889796 | 0.75 | IKBKG IKBKB CHUK | regulation of tumor necrosis factor-mediated signaling pathway |
| REAC:R-HSA-983169 | 0.0093203083965 | 0.75 | IKBKG IKBKB CHUK | Class I MHC mediated antigen processing & presentation |
| KEGG:04068 | 0.012776519361 | 0.5 | CHUK IKBKB | FoxO signaling pathway |
| REAC:R-HSA-5676590 | 0.017117349746 | 0.5 | CHUK MAP3K14 | NIK-->noncanonical NF-kB signaling |
| REAC:R-HSA-5607761 | 0.0177060142151 | 0.5 | CHUK MAP3K14 | Dectin-1 mediated noncanonical NF-kB signaling |
| WP:WP481 | 0.0195247658454 | 0.5 | IKBKB MAP3K14 | Insulin Signaling |
| KEGG:04150 | 0.0203683297936 | 0.5 | CHUK IKBKB | mTOR signaling pathway |
| GO:0002479 | 0.0215903857674 | 0.75 | IKBKG IKBKB CHUK | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent |
| GO:1902554 | 0.023464682987 | 0.75 | IKBKG IKBKB CHUK | serine/threonine protein kinase complex |
| GO:0042590 | 0.0244411426287 | 0.75 | IKBKG IKBKB CHUK | antigen processing and presentation of exogenous peptide antigen via MHC class I |
| CORUM:2123 | 0.0249595281251 | 0.25 | IKBKG | IKBKG homodimer complex |
| CORUM:5827 | 0.0249595281251 | 0.25 | IKBKG | IKBKG homotetramer complex |
| CORUM:5730 | 0.0249595281251 | 0.25 | IKBKG | IKBKG homotrimer complex |
| REAC:R-HSA-449147 | 0.0289233648573 | 0.75 | IKBKG IKBKB CHUK | Signaling by Interleukins |
| REAC:R-HSA-5668541 | 0.0356320611636 | 0.5 | CHUK MAP3K14 | TNFR2 non-canonical NF-kB pathway |
| REAC:R-HSA-168256 | 0.0358063812597 | 1.0 | IKBKG IKBKB MAP3K14 CHUK | Immune System |
| GO:1902911 | 0.0396936057372 | 0.75 | IKBKG IKBKB CHUK | protein kinase complex |
| GO:0002474 | 0.0439367749778 | 0.75 | IKBKG IKBKB CHUK | antigen processing and presentation of peptide antigen via MHC class I |
| CORUM:4043 | 0.0499140284799 | 0.25 | IKBKG | NEMO-HIF2(alpha)-ARNT complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IKBKG | IKBKB | 0.998 | 0.943 | hein_WMM bioplex (IKBKG) bioplex_WMM hein (IKBKG) |
| IKBKG | CHUK | 0.989 | 0.905 | hein_WMM bioplex (IKBKG) bioplex_WMM hein (IKBKG) |
| CHUK | IKBKB | 0.068 | 0.346 | hein_WMM bioplex (IKBKB) bioplex_WMM youn_WMM |
| CHUK | MAP3K14 | 0.063 | 0.347 | bioplex (MAP3K14) bioplex_WMM |
| IKBKB | MAP3K14 | 0.04 | 0.269 | bioplex (MAP3K14) bioplex_WMM |
| IKBKG | MAP3K14 | 0.039 | 0.264 | bioplex (MAP3K14) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_05843 has an average edge precision of 0.512 which is ranked 2432 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IKBKG | HuMAP2_01443 HuMAP2_01942 HuMAP2_04318 HuMAP2_05843 HuMAP2_06238 |
| CHUK | HuMAP2_01942 HuMAP2_05843 HuMAP2_06238 |
| IKBKB | HuMAP2_01942 HuMAP2_05843 HuMAP2_06238 |
| MAP3K14 | HuMAP2_05843 |