hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05846
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAB3GAP1 | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | UniProt NCBI |
| SIRT2 | NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | UniProt NCBI |
| GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) | UniProt NCBI |
| RAB3GAP2 | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000480 | 0.00524136889643 | 0.5 | RAB3GAP1 RAB3GAP2 | Retinal coloboma |
| HP:0000064 | 0.00524136889643 | 0.5 | RAB3GAP1 RAB3GAP2 | Hypoplastic labia minora |
| HP:0040255 | 0.00574003251223 | 0.5 | RAB3GAP1 RAB3GAP2 | Aplasia/Hypoplasia of the clitoris |
| HP:0009738 | 0.00574003251223 | 0.5 | RAB3GAP1 RAB3GAP2 | Abnormality of the antihelix |
| HP:0000060 | 0.00574003251223 | 0.5 | RAB3GAP1 RAB3GAP2 | Clitoral hypoplasia |
| HP:0001264 | 0.00737157747856 | 0.5 | RAB3GAP1 RAB3GAP2 | Spastic diplegia |
| GO:0097051 | 0.00811409485621 | 0.5 | RAB3GAP1 RAB3GAP2 | establishment of protein localization to endoplasmic reticulum membrane |
| HP:0012880 | 0.00857217497701 | 0.5 | RAB3GAP1 RAB3GAP2 | Abnormality of the labia minora |
| HP:0009465 | 0.00986303631958 | 0.5 | RAB3GAP1 RAB3GAP2 | Ulnar deviation of finger |
| HP:0001845 | 0.0119684664945 | 0.5 | RAB3GAP1 RAB3GAP2 | Overlapping toe |
| HP:0000221 | 0.0119684664945 | 0.5 | RAB3GAP1 RAB3GAP2 | Furrowed tongue |
| REAC:R-HSA-6811436 | 0.0122651619918 | 0.5 | RAB3GAP1 RAB3GAP2 | COPI-independent Golgi-to-ER retrograde traffic |
| GO:0050747 | 0.0162267366884 | 0.5 | RAB3GAP1 RAB3GAP2 | positive regulation of lipoprotein metabolic process |
| GO:1903373 | 0.0162267366884 | 0.5 | RAB3GAP1 RAB3GAP2 | positive regulation of endoplasmic reticulum tubular network organization |
| GO:1903061 | 0.0162267366884 | 0.5 | RAB3GAP1 RAB3GAP2 | positive regulation of protein lipidation |
| HP:0001193 | 0.0176695962482 | 0.5 | RAB3GAP1 RAB3GAP2 | Ulnar deviation of the hand or of fingers of the hand |
| HP:0000066 | 0.0214223630957 | 0.5 | RAB3GAP1 RAB3GAP2 | Labial hypoplasia |
| HP:0012815 | 0.023433582519 | 0.5 | RAB3GAP1 RAB3GAP2 | Hypoplastic female external genitalia |
| HP:0000649 | 0.0266188198793 | 0.5 | RAB3GAP1 RAB3GAP2 | Abnormality of visual evoked potentials |
| GO:1903371 | 0.0270421395626 | 0.5 | RAB3GAP1 RAB3GAP2 | regulation of endoplasmic reticulum tubular network organization |
| GO:1903059 | 0.0270421395626 | 0.5 | RAB3GAP1 RAB3GAP2 | regulation of protein lipidation |
| REAC:R-HSA-8876198 | 0.0356320611636 | 0.5 | RAB3GAP1 RAB3GAP2 | RAB GEFs exchange GTP for GDP on RABs |
| HP:0000058 | 0.0413775694569 | 0.5 | RAB3GAP1 RAB3GAP2 | Abnormality of the labia |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB3GAP1 | SIRT2 | 0.826 | 0.774 | bioplex (SIRT2) bioplex_WMM youn_WMM |
| SIRT2 | RAB3GAP2 | 0.69 | 0.715 | bioplex (SIRT2) bioplex_WMM youn_WMM gupta_WMM |
| SIRT2 | GPAM | 0.125 | 0.399 | bioplex (SIRT2) bioplex_WMM |
| RAB3GAP2 | GPAM | 0.008 | 0.091 | bioplex_WMM WMM_only |
| RAB3GAP1 | GPAM | 0.008 | 0.067 | bioplex_WMM WMM_only |
| RAB3GAP1 | RAB3GAP2 | 0.0 | 0.003 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
Images
Click to enlarge
Complex HuMAP2_05846 has an average edge precision of 0.341 which is ranked 4105 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RAB3GAP1 | HuMAP2_01070 HuMAP2_01196 HuMAP2_03258 HuMAP2_05816 HuMAP2_05846 HuMAP2_06645 |
| SIRT2 | HuMAP2_01196 HuMAP2_03258 HuMAP2_05816 HuMAP2_05846 HuMAP2_05876 HuMAP2_06645 |
| GPAM | HuMAP2_04031 HuMAP2_05816 HuMAP2_05846 HuMAP2_06645 |
| RAB3GAP2 | HuMAP2_01196 HuMAP2_05816 HuMAP2_05846 HuMAP2_06645 |