hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05860
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IDH3G | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Isocitric dehydrogenase subunit gamma) (NAD(+)-specific ICDH subunit gamma) | UniProt NCBI |
| IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6949 | 5.02777038712e-06 | 1.0 | IDH3G IDH3A | Isocitrate dehydrogenase [NAD], mitochondrial |
| KEGG:01210 | 1.98420660024e-05 | 1.0 | IDH3G IDH3A | 2-Oxocarboxylic acid metabolism |
| WP:WP78 | 5.06710611136e-05 | 1.0 | IDH3G IDH3A | TCA Cycle (aka Krebs or citric acid cycle) |
| KEGG:00020 | 5.9234402919e-05 | 1.0 | IDH3G IDH3A | Citrate cycle (TCA cycle) |
| REAC:R-HSA-71403 | 0.000351943927099 | 1.0 | IDH3G IDH3A | Citric acid cycle (TCA cycle) |
| KEGG:01230 | 0.000362555397177 | 1.0 | IDH3G IDH3A | Biosynthesis of amino acids |
| KEGG:01200 | 0.000939726081777 | 1.0 | IDH3G IDH3A | Carbon metabolism |
| GO:0004449 | 0.00135247023414 | 1.0 | IDH3G IDH3A | isocitrate dehydrogenase (NAD+) activity |
| REAC:R-HSA-71406 | 0.00222227451111 | 1.0 | IDH3G IDH3A | Pyruvate metabolism and Citric Acid (TCA) cycle |
| GO:0004448 | 0.00450823411379 | 1.0 | IDH3G IDH3A | isocitrate dehydrogenase activity |
| GO:0006102 | 0.00450823411379 | 1.0 | IDH3G IDH3A | isocitrate metabolic process |
| REAC:R-HSA-1428517 | 0.0226752444459 | 1.0 | IDH3G IDH3A | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0072350 | 0.029754345151 | 1.0 | IDH3G IDH3A | tricarboxylic acid metabolic process |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IDH3G | IDH3A | 0.999 | 0.948 | bioplex (IDH3A,IDH3G) bioplex_WMM Guru fraction |
Images
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Complex HuMAP2_05860 has an average edge precision of 0.948 which is ranked 349 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IDH3G | HuMAP2_00244 HuMAP2_04107 HuMAP2_05860 HuMAP2_06816 |
| IDH3A | HuMAP2_04107 HuMAP2_05860 HuMAP2_06816 |