hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05863
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APLF | Aprataxin and PNK-like factor (EC 4.2.99.18) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | UniProt NCBI |
| WRN | Werner syndrome ATP-dependent helicase (EC 3.6.4.12) (DNA helicase, RecQ-like type 3) (RecQ3) (Exonuclease WRN) (EC 3.1.-.-) (RecQ protein-like 2) | UniProt NCBI |
| XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:4082 | 1.00675659188e-05 | 0.666666666667 | WRN XRCC6 | XRCC6-XRCC5-WRN complex |
| CORUM:5235 | 2.01342304124e-05 | 0.666666666667 | WRN XRCC6 | WRN-Ku70-Ku80-PARP1 complex |
| KEGG:03450 | 0.043317794065 | 0.333333333333 | XRCC6 | Non-homologous end-joining |
| CORUM:328 | 0.0499776345577 | 0.333333333333 | XRCC6 | Ku antigen complex |
| CORUM:1217 | 0.0499776345577 | 0.333333333333 | WRN | WRN-TRF2 complex |
| CORUM:4081 | 0.0499776345577 | 0.333333333333 | XRCC6 | Ku antigen complex |
| CORUM:7282 | 0.0499776345577 | 0.333333333333 | WRN | FEN1-WRN complex |
| WP:WP438 | 0.0499785733994 | 0.333333333333 | XRCC6 | Non-homologous end joining |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| XRCC6 | WRN | 0.999 | 0.949 | hein_WMM bioplex (XRCC6) bioplex_WMM boldt youn_WMM hein (XRCC6) boldt_WMM |
| APLF | XRCC6 | 0.872 | 0.804 | bioplex (APLF,XRCC6) bioplex_WMM |
| APLF | WRN | 0.008 | 0.085 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05863 has an average edge precision of 0.613 which is ranked 1875 out of all 6965 complexes.
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