hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05867
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MEF2B | Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) | UniProt NCBI |
| MEF2B | Myocyte-specific enhancer factor 2B (RSRFR2) (Serum response factor-like protein 2) | UniProt NCBI |
| MEF2A | Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1) | UniProt NCBI |
| MEF2C | Myocyte-specific enhancer factor 2C (Myocyte enhancer factor 2C) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2029 | 5.41046835882e-09 | 1.0 | MEF2A MEF2C MEF2B MEF2B | Cell Differentiation - Index |
| WP:WP1991 | 1.06277057048e-08 | 1.0 | MEF2A MEF2C MEF2B MEF2B | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
| WP:WP2023 | 2.93067036103e-08 | 1.0 | MEF2A MEF2C MEF2B MEF2B | Cell Differentiation - Index expanded |
| WP:WP2012 | 1.67466877773e-07 | 1.0 | MEF2A MEF2C MEF2B MEF2B | miRs in Muscle Cell Differentiation |
| WP:WP1541 | 9.13982690616e-07 | 1.0 | MEF2A MEF2C MEF2B MEF2B | Energy Metabolism |
| REAC:R-HSA-525793 | 1.03407289531e-06 | 1.0 | MEF2A MEF2C MEF2B MEF2B | Myogenesis |
| KEGG:04371 | 9.32616558629e-06 | 1.0 | MEF2A MEF2C MEF2B MEF2B | Apelin signaling pathway |
| KEGG:04022 | 1.37523983447e-05 | 1.0 | MEF2A MEF2C MEF2B MEF2B | cGMP-PKG signaling pathway |
| WP:WP236 | 1.39010390619e-05 | 1.0 | MEF2A MEF2C MEF2B MEF2B | Adipogenesis |
| REAC:R-HSA-198753 | 0.00154525199441 | 0.666666666667 | MEF2C MEF2A | ERK/MAPK targets |
| REAC:R-HSA-198725 | 0.00200655101382 | 0.666666666667 | MEF2C MEF2A | Nuclear Events (kinase and transcription factor activation) |
| KEGG:04928 | 0.00207626517498 | 0.666666666667 | MEF2C MEF2A | Parathyroid hormone synthesis, secretion and action |
| REAC:R-HSA-450282 | 0.00310931782116 | 0.666666666667 | MEF2C MEF2A | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:05418 | 0.00345163215546 | 0.666666666667 | MEF2C MEF2A | Fluid shear stress and atherosclerosis |
| WP:WP366 | 0.00727489926623 | 0.666666666667 | MEF2C MEF2A | TGF-beta Signaling Pathway |
| GO:0042826 | 0.00834450158358 | 1.0 | MEF2A MEF2C MEF2B MEF2B | histone deacetylase binding |
| WP:WP2380 | 0.00875262287344 | 0.666666666667 | MEF2C MEF2A | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| WP:WP437 | 0.0121147085229 | 0.666666666667 | MEF2C MEF2A | EGF/EGFR Signaling Pathway |
| REAC:R-HSA-450294 | 0.0130404028432 | 0.666666666667 | MEF2C MEF2A | MAP kinase activation |
| REAC:R-HSA-448424 | 0.015660289467 | 0.666666666667 | MEF2C MEF2A | Interleukin-17 signaling |
| REAC:R-HSA-187037 | 0.0175395775792 | 0.666666666667 | MEF2C MEF2A | Signaling by NTRK1 (TRKA) |
| GO:0055012 | 0.020283420769 | 0.666666666667 | MEF2C MEF2A | ventricular cardiac muscle cell differentiation |
| REAC:R-HSA-975871 | 0.022155781492 | 0.666666666667 | MEF2C MEF2A | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.022155781492 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-168142 | 0.022155781492 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975138 | 0.0232544758505 | 0.666666666667 | MEF2C MEF2A | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-168181 | 0.0238137546255 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-975155 | 0.0238137546255 | 0.666666666667 | MEF2C MEF2A | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168138 | 0.0261170593829 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-166058 | 0.0261170593829 | 0.666666666667 | MEF2C MEF2A | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.0261170593829 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168164 | 0.0267094284906 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor 3 (TLR3) Cascade |
| REAC:R-HSA-166520 | 0.0273084129672 | 0.666666666667 | MEF2C MEF2A | Signaling by NTRKs |
| REAC:R-HSA-168179 | 0.0279140119136 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.0279140119136 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-166166 | 0.0285262244305 | 0.666666666667 | MEF2C MEF2A | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 0.0285262244305 | 0.666666666667 | MEF2C MEF2A | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166016 | 0.0459783176444 | 0.666666666667 | MEF2C MEF2A | Toll Like Receptor 4 (TLR4) Cascade |
| CORUM:6097 | 0.0499776345577 | 0.333333333333 | MEF2A | MEF2-NR2F2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MEF2B | MEF2B | 1.0 | 0.949 | bioplex (MEF2B) |
| MEF2C | MEF2B | 0.912 | 0.835 | bioplex (MEF2B) |
| MEF2A | MEF2B | 0.872 | 0.804 | bioplex (MEF2B) |
| MEF2C | MEF2B | 0.009 | 0.095 | bioplex_WMM WMM_only |
| MEF2A | MEF2C | 0.008 | 0.087 | bioplex_WMM WMM_only |
| MEF2A | MEF2B | 0.008 | 0.087 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05867 has an average edge precision of 0.476 which is ranked 2657 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MEF2B | HuMAP2_05107 HuMAP2_05867 |
| MEF2B | HuMAP2_05107 HuMAP2_05867 |
| MEF2A | HuMAP2_03877 HuMAP2_05107 HuMAP2_05867 |
| MEF2C | HuMAP2_05107 HuMAP2_05867 |