hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05874
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| EPB41L3 | Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) [Cleaved into: Band 4.1-like protein 3, N-terminally processed] | UniProt NCBI |
| KRT222 | Keratin-like protein KRT222 (Keratin-222) (Keratin-222 pseudogene) | UniProt NCBI |
| RUFY3 | Protein RUFY3 (RUN and FYVE domain-containing protein 3) (Rap2-interacting protein x) (RIPx) (Single axon-regulated protein) (Singar) | UniProt NCBI |
| EPB41 | Protein 4.1 (P4.1) (4.1R) (Band 4.1) (EPB4.1) | UniProt NCBI |
| EPB41L2 | Band 4.1-like protein 2 (Generally expressed protein 4.1) (4.1G) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4148 | 6.62182592439e-06 | 0.6 | EPB41L2 EPB41L3 EPB41 | Splicing factor NOVA regulated synaptic proteins |
| REAC:R-HSA-6794361 | 6.33776832781e-05 | 0.6 | EPB41L2 EPB41L3 EPB41 | Neurexins and neuroligins |
| REAC:R-HSA-6794362 | 0.00023017619861 | 0.6 | EPB41L2 EPB41L3 EPB41 | Protein-protein interactions at synapses |
| REAC:R-HSA-112316 | 0.0172109299174 | 0.6 | EPB41L2 EPB41L3 EPB41 | Neuronal System |
| GO:1904778 | 0.0450641792523 | 0.4 | EPB41L2 EPB41 | positive regulation of protein localization to cell cortex |
| CORUM:6254 | 0.0499494897235 | 0.2 | EPB41 | GPC-4.1R-p55 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| KRT222 | EPB41L2 | 0.943 | 0.856 | bioplex () boldt_WMM |
| EPB41L3 | KRT222 | 0.931 | 0.846 | bioplex () |
| EPB41L3 | EPB41L2 | 0.489 | 0.616 | bioplex (EPB41L2) bioplex_WMM youn_WMM gupta_WMM boldt_WMM |
| KRT222 | RUFY3 | 0.147 | 0.408 | bioplex () |
| KRT222 | EPB41 | 0.137 | 0.408 | bioplex () |
| EPB41L2 | EPB41 | 0.031 | 0.238 | bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| EPB41L3 | EPB41 | 0.028 | 0.231 | bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| EPB41 | RUFY3 | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
| EPB41L2 | RUFY3 | 0.007 | 0.0 | youn_WMM WMM_only boldt_WMM bioplex_WMM |
| EPB41L3 | RUFY3 | 0.007 | 0.007 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_05874 has an average edge precision of 0.361 which is ranked 3742 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| EPB41L3 | HuMAP2_02663 HuMAP2_04662 HuMAP2_05874 |
| KRT222 | HuMAP2_02663 HuMAP2_03454 HuMAP2_04662 HuMAP2_05874 |
| RUFY3 | HuMAP2_05554 HuMAP2_05874 |
| EPB41 | HuMAP2_04662 HuMAP2_05874 |
| EPB41L2 | HuMAP2_03454 HuMAP2_04662 HuMAP2_05874 |