hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05896
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IGF2 | Insulin-like growth factor II (IGF-II) (Somatomedin-A) (T3M-11-derived growth factor) [Cleaved into: Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; Preptin] | UniProt NCBI |
| AJUBA | LIM domain-containing protein ajuba | UniProt NCBI |
| IGFBP1 | Insulin-like growth factor-binding protein 1 (IBP-1) (IGF-binding protein 1) (IGFBP-1) (Placental protein 12) (PP12) | UniProt NCBI |
| TRIP6 | Thyroid receptor-interacting protein 6 (TR-interacting protein 6) (TRIP-6) (Opa-interacting protein 1) (OIP-1) (Zyxin-related protein 1) (ZRP-1) | UniProt NCBI |
| WTIP | Wilms tumor protein 1-interacting protein (WT1-interacting protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 0.00139091332341 | 0.4 | WTIP AJUBA | Hippo signaling pathway - multiple species |
| REAC:R-HSA-1234176 | 0.0278384291304 | 0.4 | WTIP AJUBA | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha |
| REAC:R-HSA-1234174 | 0.0361060371214 | 0.4 | WTIP AJUBA | Cellular response to hypoxia |
| KEGG:04390 | 0.0421802717446 | 0.4 | WTIP AJUBA | Hippo signaling pathway |
| CORUM:6191 | 0.0499494897235 | 0.2 | IGF2 | IGF2-IGFBP2 complex |
| CORUM:6237 | 0.0499494897235 | 0.2 | AJUBA | AJUBA-GFI1-HDAC1 complex |
| CORUM:6243 | 0.0499494897235 | 0.2 | AJUBA | AJUBA-GFI1-HDAC2 complex |
| CORUM:6244 | 0.0499494897235 | 0.2 | AJUBA | AJUBA-GFI1-HDAC3 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| WTIP | TRIP6 | 0.962 | 0.87 | bioplex (TRIP6) bioplex_WMM youn_WMM |
| AJUBA | TRIP6 | 0.32 | 0.511 | bioplex (TRIP6) bioplex_WMM |
| IGFBP1 | TRIP6 | 0.21 | 0.458 | bioplex (IGFBP1) bioplex_WMM |
| IGF2 | IGFBP1 | 0.089 | 0.355 | bioplex (IGFBP1) bioplex_WMM |
| AJUBA | WTIP | 0.009 | 0.092 | bioplex_WMM WMM_only |
| IGF2 | TRIP6 | 0.007 | 0.009 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05896 has an average edge precision of 0.383 which is ranked 3503 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| IGF2 | HuMAP2_02396 HuMAP2_03939 HuMAP2_04074 HuMAP2_05896 |
| AJUBA | HuMAP2_02396 HuMAP2_05896 |
| IGFBP1 | HuMAP2_02396 HuMAP2_03939 HuMAP2_04074 HuMAP2_05896 |
| TRIP6 | HuMAP2_02396 HuMAP2_04582 HuMAP2_05896 |
| WTIP | HuMAP2_02396 HuMAP2_04582 HuMAP2_05765 HuMAP2_05896 |