hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_05897
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KDM3A | Lysine-specific demethylase 3A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) | UniProt NCBI |
| STK4 | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | UniProt NCBI |
| STK3 | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | UniProt NCBI |
| RASSF2 | Ras association domain-containing protein 2 | UniProt NCBI |
| SAV1 | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | UniProt NCBI |
| RASSF6 | Ras association domain-containing protein 6 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 5.05349951212e-09 | 0.666666666667 | RASSF2 STK3 RASSF6 SAV1 | Hippo signaling pathway - multiple species |
| REAC:R-HSA-2028269 | 5.75676182894e-06 | 0.5 | STK3 STK4 SAV1 | Signaling by Hippo |
| CORUM:6403 | 8.39001385941e-06 | 0.333333333333 | SAV1 STK4 | MST1-SAV1 complex |
| CORUM:6404 | 8.39001385941e-06 | 0.333333333333 | STK3 SAV1 | MST2-SAV1 complex |
| CORUM:6621 | 2.51655344529e-05 | 0.333333333333 | STK3 SAV1 | NEK2A-SAV1-STK3 complex |
| CORUM:6716 | 2.51655344529e-05 | 0.333333333333 | STK3 STK4 | DLG5-MST1-MST2 complex |
| KEGG:04390 | 0.00076933519084 | 0.5 | STK3 RASSF6 SAV1 | Hippo signaling pathway |
| WP:WP4537 | 0.00105843860426 | 0.333333333333 | STK3 SAV1 | Hippo-Yap signaling pathway |
| WP:WP4542 | 0.00241892882621 | 0.333333333333 | STK3 SAV1 | Overview of leukocyte-intrinsic Hippo pathway functions |
| WP:WP4534 | 0.00455083797199 | 0.333333333333 | STK3 SAV1 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| GO:0035329 | 0.0140408309691 | 0.5 | STK3 STK4 SAV1 | hippo signaling |
| MIRNA:hsa-miR-1256 | 0.0233911114642 | 0.333333333333 | STK4 RASSF6 | hsa-miR-1256 |
| WP:WP4541 | 0.0282758493646 | 0.333333333333 | STK3 SAV1 | Hippo-Merlin Signaling Dysregulation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| STK4 | STK3 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| STK4 | RASSF2 | 0.988 | 0.901 | bioplex (RASSF2) bioplex_WMM gupta_WMM |
| STK3 | RASSF2 | 0.977 | 0.893 | bioplex (RASSF2) bioplex_WMM gupta_WMM |
| SAV1 | STK3 | 0.324 | 0.512 | bioplex (SAV1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| SAV1 | STK4 | 0.155 | 0.416 | bioplex (SAV1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STK4 | RASSF6 | 0.068 | 0.349 | bioplex (RASSF6) bioplex_WMM |
| STK3 | RASSF6 | 0.036 | 0.267 | bioplex (RASSF6) bioplex_WMM |
| KDM3A | RASSF6 | 0.028 | 0.231 | bioplex (RASSF6) bioplex_WMM |
| KDM3A | STK4 | 0.008 | 0.069 | bioplex_WMM WMM_only |
| KDM3A | STK3 | 0.008 | 0.031 | bioplex_WMM youn_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_05897 has an average edge precision of 0.462 which is ranked 2790 out of all 6965 complexes.
Related Complexes