hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05904
Confidence: Extremely High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| XAB2 | Pre-mRNA-splicing factor SYF1 (Protein HCNP) (XPA-binding protein 2) | UniProt NCBI |
| CRNKL1 | Crooked neck-like protein 1 (Crooked neck homolog) (hCrn) | UniProt NCBI |
| PPIE | Peptidyl-prolyl cis-trans isomerase E (PPIase E) (EC 5.2.1.8) (Cyclophilin E) (Cyclophilin-33) (Rotamase E) | UniProt NCBI |
| ISY1 | Pre-mRNA-splicing factor ISY1 homolog | UniProt NCBI |
| AQR | RNA helicase aquarius (EC 3.6.4.13) (Intron-binding protein of 160 kDa) (IBP160) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1181 | 2.5735197565e-10 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | C complex spliceosome |
| KEGG:03040 | 2.23322702966e-09 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | Spliceosome |
| CORUM:351 | 5.08296361811e-09 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | Spliceosome |
| REAC:R-HSA-72163 | 3.45105311094e-08 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 4.31006066442e-08 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | mRNA Splicing |
| REAC:R-HSA-6781823 | 1.06659036688e-07 | 0.8 | XAB2 AQR PPIE ISY1 | Formation of TC-NER Pre-Incision Complex |
| REAC:R-HSA-72203 | 1.40345345848e-07 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-6782210 | 2.31293212985e-07 | 0.8 | XAB2 AQR PPIE ISY1 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| GO:0071013 | 2.37847679293e-07 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | catalytic step 2 spliceosome |
| REAC:R-HSA-6782135 | 2.46446696587e-07 | 0.8 | XAB2 AQR PPIE ISY1 | Dual incision in TC-NER |
| GO:0005684 | 3.80961167992e-07 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | U2-type spliceosomal complex |
| REAC:R-HSA-6781827 | 5.1886356556e-07 | 0.8 | XAB2 AQR PPIE ISY1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-5696398 | 2.09637710842e-06 | 0.8 | XAB2 AQR PPIE ISY1 | Nucleotide Excision Repair |
| GO:0071007 | 3.33813219873e-06 | 0.8 | XAB2 AQR CRNKL1 PPIE | U2-type catalytic step 2 spliceosome |
| GO:0005681 | 6.93592836046e-06 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | spliceosomal complex |
| REAC:R-HSA-8953854 | 2.37148320446e-05 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | Metabolism of RNA |
| GO:0006283 | 0.000132272122238 | 0.8 | XAB2 AQR PPIE ISY1 | transcription-coupled nucleotide-excision repair |
| REAC:R-HSA-73894 | 0.00015586029631 | 0.8 | XAB2 AQR PPIE ISY1 | DNA Repair |
| GO:0000377 | 0.000195429782732 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 0.000195429782732 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | mRNA splicing, via spliceosome |
| GO:0000375 | 0.000205071070663 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | RNA splicing, via transesterification reactions |
| GO:0000974 | 0.000259479548289 | 0.6 | XAB2 CRNKL1 ISY1 | Prp19 complex |
| GO:0071014 | 0.000259479548289 | 0.6 | XAB2 CRNKL1 ISY1 | post-mRNA release spliceosomal complex |
| GO:0008380 | 0.000460710313953 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | RNA splicing |
| GO:0006289 | 0.0005799178998 | 0.8 | XAB2 AQR PPIE ISY1 | nucleotide-excision repair |
| GO:0006397 | 0.00066476318296 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | mRNA processing |
| GO:0016071 | 0.0124036237668 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | mRNA metabolic process |
| GO:1990904 | 0.0163080003193 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | ribonucleoprotein complex |
| GO:0006396 | 0.0184779947673 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | RNA processing |
| GO:0000393 | 0.0450641792523 | 0.4 | XAB2 ISY1 | spliceosomal conformational changes to generate catalytic conformation |
| CORUM:0000000 | 0.0474603483533 | 1.0 | XAB2 AQR ISY1 CRNKL1 PPIE | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CRNKL1 | XAB2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo gupta_WMM fraction treiber_WMM |
| ISY1 | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru hein (CRNKL1) Malo fraction |
| PPIE | AQR | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM Malo fraction |
| CRNKL1 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo gupta_WMM fraction treiber_WMM |
| PPIE | ISY1 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru Malo fraction |
| ISY1 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
| PPIE | XAB2 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM Malo fraction |
| XAB2 | AQR | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM |
| PPIE | CRNKL1 | 1.0 | 0.949 | hein_WMM bioplex (PPIE) bioplex_WMM Guru youn_WMM hein (CRNKL1) Malo fraction |
| ISY1 | XAB2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru Malo fraction |
Images
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Complex HuMAP2_05904 has an average edge precision of 0.949 which is ranked 2 out of all 6965 complexes.
Related Complexes