hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05914
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| KDM3A | Lysine-specific demethylase 3A (EC 1.14.11.-) (JmjC domain-containing histone demethylation protein 2A) (Jumonji domain-containing protein 1A) | UniProt NCBI |
| STK4 | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | UniProt NCBI |
| STK3 | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | UniProt NCBI |
| RASSF2 | Ras association domain-containing protein 2 | UniProt NCBI |
| RASSF1 | Ras association domain-containing protein 1 | UniProt NCBI |
| SAV1 | Protein salvador homolog 1 (45 kDa WW domain protein) (hWW45) | UniProt NCBI |
| C4orf46 | Renal cancer differentiation gene 1 protein | UniProt NCBI |
| KIF2B | Kinesin-like protein KIF2B | UniProt NCBI |
| RASSF6 | Ras association domain-containing protein 6 | UniProt NCBI |
| ADCYAP1 | Pituitary adenylate cyclase-activating polypeptide (PACAP) [Cleaved into: PACAP-related peptide (PRP-48); Pituitary adenylate cyclase-activating polypeptide 27 (PACAP-27) (PACAP27); Pituitary adenylate cyclase-activating polypeptide 38 (PACAP-38) (PACAP38)] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 1.29805560981e-10 | 0.5 | RASSF2 STK3 RASSF6 RASSF1 SAV1 | Hippo signaling pathway - multiple species |
| WP:WP4537 | 1.5417864139e-05 | 0.3 | STK3 RASSF1 SAV1 | Hippo-Yap signaling pathway |
| CORUM:6403 | 3.01890677263e-05 | 0.2 | STK4 SAV1 | MST1-SAV1 complex |
| CORUM:6404 | 3.01890677263e-05 | 0.2 | STK3 SAV1 | MST2-SAV1 complex |
| REAC:R-HSA-2028269 | 4.39370578466e-05 | 0.3 | STK4 SAV1 STK3 | Signaling by Hippo |
| KEGG:04390 | 7.64814622203e-05 | 0.4 | STK3 RASSF6 RASSF1 SAV1 | Hippo signaling pathway |
| CORUM:6621 | 9.0534767973e-05 | 0.2 | STK3 SAV1 | NEK2A-SAV1-STK3 complex |
| CORUM:6716 | 9.0534767973e-05 | 0.2 | STK4 STK3 | DLG5-MST1-MST2 complex |
| WP:WP4542 | 0.0109073591456 | 0.2 | STK3 SAV1 | Overview of leukocyte-intrinsic Hippo pathway functions |
| WP:WP4534 | 0.0204801297149 | 0.2 | STK3 SAV1 | Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms |
| WP:WP3959 | 0.0369034425738 | 0.2 | STK3 RASSF1 | DNA IR-Double Strand Breaks (DSBs) and cellular response via ATM |
| KEGG:05223 | 0.0384618026607 | 0.2 | STK4 RASSF1 | Non-small cell lung cancer |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RASSF1 | STK4 | 1.0 | 0.949 | hein_WMM bioplex (RASSF1) bioplex_WMM hein (RASSF1) |
| STK4 | STK3 | 1.0 | 0.949 | hein_WMM bioplex_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| RASSF1 | STK3 | 0.999 | 0.949 | hein_WMM bioplex (RASSF1) bioplex_WMM hein (RASSF1) |
| STK4 | RASSF2 | 0.988 | 0.901 | bioplex (RASSF2) bioplex_WMM gupta_WMM |
| STK3 | RASSF2 | 0.977 | 0.893 | bioplex (RASSF2) bioplex_WMM gupta_WMM |
| SAV1 | STK3 | 0.324 | 0.512 | bioplex (SAV1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| ADCYAP1 | SAV1 | 0.268 | 0.482 | bioplex (ADCYAP1) bioplex_WMM |
| SAV1 | STK4 | 0.155 | 0.416 | bioplex (SAV1) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| STK4 | RASSF6 | 0.068 | 0.349 | bioplex (RASSF6) bioplex_WMM |
| SAV1 | KIF2B | 0.047 | 0.293 | bioplex (KIF2B) bioplex_WMM |
| STK3 | RASSF6 | 0.036 | 0.267 | bioplex (RASSF6) bioplex_WMM |
| KDM3A | RASSF6 | 0.028 | 0.231 | bioplex (RASSF6) bioplex_WMM |
| KIF2B | C4orf46 | 0.027 | 0.223 | bioplex (KIF2B) bioplex_WMM |
| KDM3A | STK4 | 0.008 | 0.069 | bioplex_WMM WMM_only |
| KDM3A | STK3 | 0.008 | 0.031 | bioplex_WMM youn_WMM WMM_only |
| C4orf46 | STK4 | 0.008 | 0.026 | bioplex_WMM WMM_only |
| C4orf46 | STK3 | 0.008 | 0.012 | bioplex_WMM WMM_only |
| SAV1 | C4orf46 | 0.007 | 0.012 | bioplex_WMM WMM_only |
| KIF2B | STK3 | 0.006 | 0.01 | bioplex (KIF2B) bioplex_WMM |
| KIF2B | STK4 | 0.005 | 0.007 | bioplex (KIF2B) bioplex_WMM |
| ADCYAP1 | STK4 | 0.0 | 0.011 | bioplex (ADCYAP1) bioplex_WMM |
| ADCYAP1 | STK3 | 0.0 | 0.004 | bioplex (ADCYAP1) bioplex_WMM |
Images
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Complex HuMAP2_05914 has an average edge precision of 0.345 which is ranked 4056 out of all 6965 complexes.
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