hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_05915
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UBE2V2 | Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein) | UniProt NCBI |
| UBE2N | Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N) | UniProt NCBI |
| SMAP1 | Stromal membrane-associated protein 1 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2756 | 3.35600554376e-06 | 0.666666666667 | UBE2N UBE2V2 | Ubiquitin ligase (UBE2N, UBE2V2) |
| CORUM:7051 | 1.00675659188e-05 | 0.666666666667 | UBE2N UBE2V2 | OTUB1-UBC13-MMS2 complex |
| GO:0031372 | 0.00135247023414 | 0.666666666667 | UBE2N UBE2V2 | UBC13-MMS2 complex |
| REAC:R-HSA-5696395 | 0.00603484671946 | 0.666666666667 | UBE2N UBE2V2 | Formation of Incision Complex in GG-NER |
| REAC:R-HSA-8866654 | 0.0102859860332 | 0.666666666667 | UBE2N UBE2V2 | E3 ubiquitin ligases ubiquitinate target proteins |
| REAC:R-HSA-5693571 | 0.015660289467 | 0.666666666667 | UBE2N UBE2V2 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-8852135 | 0.0185190091635 | 0.666666666667 | UBE2N UBE2V2 | Protein ubiquitination |
| REAC:R-HSA-5693565 | 0.0190186686906 | 0.666666666667 | UBE2N UBE2V2 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.0195249561753 | 0.666666666667 | UBE2N UBE2V2 | DNA Double Strand Break Response |
| REAC:R-HSA-5696399 | 0.0232544758505 | 0.666666666667 | UBE2N UBE2V2 | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-69473 | 0.0291450496188 | 0.666666666667 | UBE2N UBE2V2 | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 0.03104119222 | 0.666666666667 | UBE2N UBE2V2 | Processing of DNA double-strand break ends |
| REAC:R-HSA-5696398 | 0.0399448421955 | 0.666666666667 | UBE2N UBE2V2 | Nucleotide Excision Repair |
| GO:0031371 | 0.0486736709081 | 0.666666666667 | UBE2N UBE2V2 | ubiquitin conjugating enzyme complex |
| CORUM:6025 | 0.0499776345577 | 0.333333333333 | UBE2N | Ubiquitin-conjugating enzyme E2 (UBC13-UEV1A) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| UBE2V2 | UBE2N | 0.988 | 0.901 | bioplex_WMM boldt (UBE2N) fraction boldt_WMM |
| SMAP1 | UBE2N | 0.078 | 0.352 | bioplex_WMM youn_WMM fraction |
| SMAP1 | UBE2V2 | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_05915 has an average edge precision of 0.419 which is ranked 3118 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UBE2V2 | HuMAP2_03473 HuMAP2_04263 HuMAP2_05809 HuMAP2_05915 |
| UBE2N | HuMAP2_05809 HuMAP2_05915 HuMAP2_06063 |
| SMAP1 | HuMAP2_02118 HuMAP2_04603 HuMAP2_05915 HuMAP2_06767 |